Coexpression of vascular endothelial growth factor and its receptor KDR on gastric adenocarcinoma MGC803 cell line and stimulation of exogenous VEGF165 to MGC803 cells

2000 ◽  
Vol 43 (1) ◽  
pp. 88-95
Author(s):  
Xuejun Tian ◽  
Lin Meng ◽  
Chengchao Shou ◽  
Zhiwei Dong
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
Gastric Adenocarcinoma ◽  
Vascular Endothelial ◽  
Mgc803 Cell ◽  
Endothelial Growth Factor ◽  
Stimulation Of

Neopterin as a Stimulator of Vascular Endothelial Growth Factor and Erythropoietin Gene Expression in an Ovarian Carcinoma Cell Line

Pteridines ◽  
2005 ◽  
Vol 16 (4) ◽  
pp. 166-173 ◽  
Author(s):  
Josef Rieder ◽  
Christian Marth ◽  
Wolfgang Schobersberger ◽  
Georg Hoffmann
Keyword(s):  
Gene Expression ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Ovarian Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Vascular Endothelial ◽  
Ovarian Carcinoma Cell Line ◽  
Endothelial Growth Factor ◽  
Stimulation Of

Abstract Increases in serum neopterin concentrations are a regular finding in patients with ovarian cancer. The strong correlation between neopterin and tumor progression might be explained by a direct influence of the pteridine compound on tumor cell growth. In the present study we investigated whether neopterin affects the production of the angiogenic promotors vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in the human ovarian carcinoma cell line OVCAR-3. VEGF and EPO gene expression were detected via RT-PCR. and a possible involvement of hypoxiainducible factor-1 was assessed by electrophoretic mobility shift assays. Neopterin amplified the hypoxia-induced VEGF and EPO gene expression as well as protein synthesis in a concentration-dependent manner. In addition, generation of both VEGF and EPO could be detected following incubation of cells with neopterin under normoxic conditions, too. Neopterin-induced synthesis of VEGF and EPO was preceeded by a stimulation of hypoxiainducible factor-1 uptake into the nucleus of OVCAR-3 cells. From these data we conclude that neopterin acts as a mediator of angiogenesis. Stimulation of VEGF and EPO generation in ovarian carcinoma cells may promote vascularization of the malignant tissue and thus tumor growth and development.

Expression and Regulation of Vascular Endothelial Growth Factor in a First Trimester Trophoblast Cell Line

Placenta ◽  
2000 ◽  
Vol 21 (4) ◽  
pp. 320-324 ◽  
Author(s):  
I-B. Chung ◽  
F.D. Yelian ◽  
F.M. Zaher ◽  
B. Gonik ◽  
M.I. Evans ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
First Trimester ◽  
Trophoblast Cell ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Trophoblast Cell Line

scholarly journals Direct Stimulation of Adult Neural Stem Cells In Vitro and Neurogenesis In Vivo by Vascular Endothelial Growth Factor

2006 ◽  
Vol 14 (3) ◽  
pp. 237-248 ◽  
Author(s):  
Anne Schänzer ◽  
Frank-Peter Wachs ◽  
Daniel Wilhelm ◽  
Till Acker ◽  
Christiana Cooper-Kuhn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Vascular Endothelial ◽  
Direct Stimulation ◽  
Endothelial Growth Factor ◽  
Stimulation Of

scholarly journals Streptococcus pneumoniae Induces Secretion of Vascular Endothelial Growth Factor by Human Neutrophils

2000 ◽  
Vol 68 (8) ◽  
pp. 4792-4794 ◽  
Author(s):  
Michiel van der Flier ◽  
Frank Coenjaerts ◽  
Jan L. L. Kimpen ◽  
Andy M. Hoepelman ◽  
Sibyl P. M. Geelen
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Permeability ◽  
Pneumococcal Disease ◽  
Endothelial Permeability ◽  
Human Neutrophils ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Stimulation Of

ABSTRACT Infection by pneumococci causes an acute inflammatory response associated with neutrophil influx, increased vascular permeability, and edema. Vascular endothelial growth factor (VEGF) is one of the most potent regulators of endothelial permeability. In vitro stimulation of neutrophils showed that pneumococci and purified pneumococcal cell wall induce VEGF secretion, independent of the presence of pneumolysin or polysaccharide capsule. The results of this study indicate VEGF is secreted in pneumococcal disease, suggesting a role as a mediator of increased vascular permeability.

Identification of a vascular endothelial growth factor (VEGF) antagonist, sFlt-1, from a human hematopoietic cell line NALM-16

FEBS Letters ◽  
2000 ◽  
Vol 469 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Toshiya Inoue ◽  
Keiko Kibata ◽  
Motoyuki Suzuki ◽  
Shuji Nakamura ◽  
Ryuichi Motoda ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
Hematopoietic Cell ◽  
Vascular Endothelial ◽  
Hematopoietic Cell Line ◽  
Endothelial Growth Factor
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