The role of immediate early genes in the stabilization of long-term potentiation

1991 ◽  
Vol 5 (2-4) ◽  
pp. 297-314 ◽  
Author(s):  
Wickliffe C. Abraham ◽  
Michael Dragunow ◽  
Warren P. Tate
Keyword(s):  
Immediate Early Genes ◽  
Long Term Potentiation ◽  
Immediate Early ◽  
Early Genes ◽  
Term Potentiation

Immediate-early genes, kindling and long-term potentiation

1989 ◽  
Vol 13 (4) ◽  
pp. 301-313 ◽  
Author(s):  
M. Dragunow ◽  
R.W. Currie ◽  
R.L.M. Faull ◽  
H.A. Robertson ◽  
K. Jansen
Keyword(s):  
Immediate Early Genes ◽  
Long Term Potentiation ◽  
Immediate Early ◽  
Early Genes ◽  
Term Potentiation

scholarly journals A negative correlation between the induction of long-term potentiation and activation of immediate early genes

1991 ◽  
Vol 11 (1) ◽  
pp. 89-91 ◽  
Author(s):  
Steven S. Schreiber ◽  
Stephen Maren ◽  
Georges Tocco ◽  
Tracey Jo Shors ◽  
Richard F. Thompson
Keyword(s):  
Negative Correlation ◽  
Immediate Early Genes ◽  
Long Term Potentiation ◽  
Immediate Early ◽  
Early Genes ◽  
Term Potentiation

Differential expression of immediate early genes after hippocampal long-term potentiation in awake rats

1993 ◽  
Vol 17 (3-4) ◽  
pp. 279-286 ◽  
Author(s):  
Jerome Demmer ◽  
Michael Dragunow ◽  
Patricia A. Lawlor ◽  
Sara E. Mason ◽  
John D. Leah ◽  
...  
Keyword(s):  
Differential Expression ◽  
Immediate Early Genes ◽  
Long Term Potentiation ◽  
Immediate Early ◽  
Early Genes ◽  
Term Potentiation ◽  
Awake Rats

scholarly journals Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

2021 ◽  
Author(s):  
Sujeong Yang ◽  
Sylvain Gigout ◽  
Angelo Molinaro ◽  
Yuko Naito-Matsui ◽  
Sam Hilton ◽  
...  
Keyword(s):  
Chondroitin Sulphate ◽  
Memory Loss ◽  
Memory Deficits ◽  
Long Term Potentiation ◽  
Aged Mice ◽  
Age Related ◽  
Term Potentiation ◽  
Early Memory

AbstractPerineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice. We first confirmed that aged mice (20-months) showed memory and plasticity deficits. They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated. We then explored the role of C6S in memory and neuroplasticity. Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains. These animals showed very early memory loss at 11 weeks old. Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.

Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain

2017 ◽  
Vol 23 (6) ◽  
pp. 587-604 ◽  
Author(s):  
Julien Gibon ◽  
Philip A. Barker
Keyword(s):  
Long Term Potentiation ◽  
Synaptic Activity ◽  
Cellular Processes ◽  
Term Potentiation ◽  
Neurotrophin 3 ◽  
New Findings ◽  
The Central Nervous System ◽  
The Brain

Neurotrophins have been intensively studied and have multiple roles in the brain. Neurotrophins are first synthetized as proneurotrophins and then cleaved intracellularly and extracellularly. Increasing evidences demonstrate that proneurotrophins and mature neurotrophins exerts opposing role in the central nervous system. In the present review, we explore the role of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4) and their respective proform in cellular processes related to learning and memory. We focused on their roles in synaptic activity and plasticity in the brain with an emphasis on long-term potentiation, long-term depression, and basal synaptic transmission in the hippocampus and the temporal lobe area. We also discuss new findings on the role of the Val66Met polymorphism on the BDNF propeptide on synaptic activity.

scholarly journals Examination of the role of cGMP in long-term potentiation in the CA1 region of the hippocampus.

1996 ◽  
Vol 3 (1) ◽  
pp. 42-48 ◽  
Author(s):  
D K Selig ◽  
M R Segal ◽  
D Liao ◽  
R C Malenka ◽  
R Malinow ◽  
...  
Keyword(s):  
Long Term Potentiation ◽  
Ca1 Region ◽  
Term Potentiation
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