Comparison between continuous and intermittent physical exercise on aging rats: Changes in patterns of spontaneous activity and connective tissue stability

1999 ◽  
Vol 11 (4) ◽  
pp. 227-234 ◽  
Author(s):  
M. Skalicky ◽  
A. Viidik
Keyword(s):  
Connective Tissue ◽  
Physical Exercise ◽  
Spontaneous Activity ◽  
Aging Rats

Retardation of the age-associated decline of immune functions in aging rats under dietary restriction and daily physical exercise

1996 ◽  
Vol 91 (3) ◽  
pp. 219-228 ◽  
Author(s):  
Masanori Utsuyama ◽  
Mineko Ichikawa ◽  
Aiko Konno-Shirakawa ◽  
Yoshiaki Fujita ◽  
K. Hirokawa
Keyword(s):  
Physical Exercise ◽  
Dietary Restriction ◽  
Immune Functions ◽  
Aging Rats

scholarly journals Advanced Glycation End Products Increase Salivary Gland Hypofunction in d-Galactose-Induced Aging Rats and Its Prevention by Physical Exercise

2021 ◽  
Vol 43 (3) ◽  
pp. 2059-2067
Author(s):  
Woo Kwon Jung ◽  
Su-Bin Park ◽  
Hyung Rae Kim ◽  
Hwa Young Ryu ◽  
Yong Hwan Kim ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Physical Exercise ◽  
Advanced Glycation End Products ◽  
Aging Process ◽  
Advanced Glycation ◽  
Young Control ◽  
Aging Rats ◽  
Age Related ◽  
Glycation End Products ◽  
End Products

A declined salivary gland function is commonly observed in elderly people. Advanced glycation end products (AGEs) are believed to contribute to the pathogenesis of aging. Although physical exercise is shown to increase various organ functions in human and experimental models, it is not known whether it has a similar effect in the salivary glands. In the present study, we evaluated the AGEs burden in the salivary gland in the aging process and the protective effect of physical exercise on age-related salivary hypofunction. To accelerate the aging process, rats were peritoneally injected with D-galactose for 6 weeks. Young control rats and d-galactose-induced aging rats in the old group were not exercised. The rats in the physical exercise group ran on a treadmill (12 m/min, 60 min/day, 3 days/week for 6 weeks). The results showed that the salivary flow rate and total protein levels in the saliva of the d-galactose-induced aging rats were reduced compared to those of the young control rats. Circulating AGEs in serum and secreted AGEs in saliva increased with d-galactose-induced aging. AGEs also accumulated in the salivary glands of these aging rats. The salivary gland of aging rats showed increased reactive oxygen species (ROS) generation, loss of acinar cells, and apoptosis compared to young control mice. However, physical exercise suppressed all of these age-related salivary changes. Overall, physical exercise could provide a beneficial option for age-related salivary hypofunction.

Electron Microscopic Study of the Epithelium of the Seminal Vesicle of Aging Rats

1974 ◽  
Vol 32 ◽  
pp. 138-139
Author(s):  
V. F. Allison ◽  
G. C. Fink ◽  
G. W. Cearley
Keyword(s):  
Cell Growth ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Seminal Vesicle ◽  
Seminal Vesicles ◽  
Epithelial Layer ◽  
Epithelial Hyperplasia ◽  
Electron Microscopic ◽  
Aging Rats ◽  
Pseudostratified Epithelium

It is well known that epithelial hyperplasia (benign hypertrophy) is common in the aging prostate of dogs and man. In contrast, little evidence is available for abnormal epithelial cell growth in seminal vesicles of aging animals. Recently, enlarged seminal vesicles were reported in senescent mice, however, that enlargement resulted from increased storage of secretion in the lumen and occurred concomitant to epithelial hypoplasia in that species.The present study is concerned with electron microscopic observations of changes occurring in the pseudostratified epithelium of the seminal vescles of aging rats. Special attention is given to certain non-epithelial cells which have entered the epithelial layer.

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