Low free plasma levels of retinol-binding protein 4 in insulin-resistant subjects with polycystic ovary syndrome

2008 ◽  
Vol 31 (11) ◽  
pp. 950-955 ◽  
Author(s):  
E. Diamanti-Kandarakis ◽  
S. Livadas ◽  
S. A. Kandarakis ◽  
I. Papassotiriou ◽  
A. Margeli
Diabetes Care ◽  
2008 ◽  
Vol 31 (7) ◽  
pp. 1427-1432 ◽  
Author(s):  
S. K. Hutchison ◽  
C. Harrison ◽  
N. Stepto ◽  
C. Meyer ◽  
H. J. Teede

2019 ◽  
Vol 8 (6) ◽  
pp. 709-717
Author(s):  
Shilpa Lingaiah ◽  
Laure Morin-Papunen ◽  
Terhi Piltonen ◽  
Inger Sundström-Poromaa ◽  
Elisabet Stener-Victorin ◽  
...  

Objective Serum levels of retinol-binding protein 4 (RBP4), an adipokine thought to affect systemic insulin sensitivity, were compared between women with polycystic ovary syndrome (PCOS) and non-PCOS controls to evaluate the association of RBP4 with clinical, hormonal and metabolic parameters of PCOS. Subjects and methods Serum RBP4 levels were analysed in 278 women with PCOS (age range 18–57 years) and 191 non-PCOS controls (age 20–53 years) by enzyme-linked immunosorbent assay. Results Serum levels of RBP4 were increased in women with PCOS compared with control women in the whole population (45.1 ± 24.0 (s.d.) vs 33.5 ± 18.3 mg/L, P < 0.001). Age-stratified analysis showed that serum RBP4 levels were increased in women with PCOS aged ≤30 years compared with controls (47.7 ± 23.5 vs 27.1 ± 10.4 mg/L, P < 0.001), whereas no significant differences were seen in the other age groups. No significant correlations of RBP4 were seen with either steroids or indices of insulin resistance. Conclusions Although serum RBP4 levels were increased in younger women with PCOS compared with age-matched non-PCOS controls, RBP4 does not seem to be a good marker of insulin resistance or other metabolic derangements in women with PCOS.


2013 ◽  
Vol 75 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Young Eun Jeon ◽  
Kyung Eun Lee ◽  
Ji Ann Jung ◽  
Su Youn Yim ◽  
HyeYeon Kim ◽  
...  

2010 ◽  
Vol 93 (3) ◽  
pp. 869-873 ◽  
Author(s):  
Te-Fu Chan ◽  
Yung-Chieh Tsai ◽  
Pu-Rong Chiu ◽  
Yi-Ling Chen ◽  
Chien-Hung Lee ◽  
...  

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