Plasma free fatty acids and serum insulin in subjects feeding at 12-hour intervals; effects of methionyl growth hormone and of acipimox, an inhibitor of lipolysis

1992 ◽  
Vol 15 (2) ◽  
pp. 85-91 ◽  
Author(s):  
A. E. Pontiroli ◽  
R. Lanzi ◽  
M. Monzani ◽  
L. Musatti ◽  
C. Guglielmone ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Free Fatty Acids ◽  
Serum Insulin ◽  
Plasma Free Fatty Acids

Metabolic Changes in Active Chronic Hepatitis

1972 ◽  
Vol 42 (5) ◽  
pp. 591-605 ◽  
Author(s):  
K. G. M. M. Alberti ◽  
C. O. Record ◽  
D. H. Williamson ◽  
R. Wright
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Chronic Hepatitis ◽  
Free Fatty Acids ◽  
Blood Lactate ◽  
Ketone Bodies ◽  
Serum Insulin ◽  
Insulin Response ◽  
Active Chronic Hepatitis ◽  
Intravenous Glucose

1. The metabolic and hormonal responses to intravenous glucose (0·5 g/kg body wt.) were studied in ten normal subjects and thirteen patients with active chronic hepatitis. Untreated patients showed a decreased initial insulin response and glucose intolerance (KG, 0·89 ± 0·10%/min compared with 2·34 ± 0·24%/min), together with a paradoxical rise in growth hormone. 2. Fasting blood lactate and pyruvate were normal but both metabolites showed a diminished rise after glucose. The rate of rise of lactate was directly related to initial insulin secretion in both hepatitis subjects and controls. 3. Fasting blood ketone bodies, blood glycerol, plasma triglycerides and free fatty acids were all significantly elevated in the patient group. Results were similar to those found in mild diabetes mellitus. 4. In two patients with a more severe cirrhosis fasting values of serum insulin, growth hormone, blood lactate, pyruvate and glycerol were raised. 5. After corticosteroid therapy hyperinsulinism was found together with a return towards normal of glucose tolerance (KG, 1·49 + 0·10%/min), ketone bodies, free fatty acids and triglycerides; blood glycerol remained elevated and lactate response to glucose was excessive. 6. It is suggested that in active chronic hepatitis there might be pancreatic dysfunction on an autoimmune basis.

Effect of plasma free fatty acids on plasma glucagon and serum insulin concentrations

Metabolism ◽  
1968 ◽  
Vol 17 (4) ◽  
pp. 301-304 ◽  
Author(s):  
Leonard L. Madison ◽  
Willis A. Seyffert ◽  
Roger H. Unger ◽  
Barbara Barker
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Serum Insulin ◽  
Plasma Glucagon ◽  
Plasma Free Fatty Acids

scholarly journals Studies on the relationship between plasma free fatty acids and growth hormone secretion in man

1972 ◽  
Vol 51 (9) ◽  
pp. 2388-2398 ◽  
Author(s):  
Hans-Jürgen Quabbe ◽  
Hans-Jürgen Bratzke ◽  
Ulrike Siegers ◽  
Kadip Elban
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Free Fatty Acids ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Plasma Free Fatty Acids ◽  
The Relationship
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