Prolactin secretion in idiopathic hypogonadotropic hypogonadism during pulsatile luteinizing hormone-releasing hormone long-term administration

1989 ◽  
Vol 12 (8) ◽  
pp. 523-529 ◽  
Author(s):  
M. Giusti ◽  
Laura Traverso ◽  
P. Cavagnaro ◽  
R. Torre ◽  
R. Durante ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Hypogonadotropic Hypogonadism ◽  
Prolactin Secretion ◽  
Idiopathic Hypogonadotropic Hypogonadism ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Term Administration

scholarly journals A Patient with Hypogonadotropic Hypogonadism Successfully Treated by Long-Term Pulsatile Administration of Luteinizing Hormone-Releasing Hormone.

1988 ◽  
Vol 35 (6) ◽  
pp. 925-931 ◽  
Author(s):  
TOSHIO ONISHI ◽  
SHIGETO MORIMOTO ◽  
HIDEKI YAMAMOTO ◽  
SHOSHI TAKAMOTO ◽  
KEISUKE FUKUO ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Hypogonadotropic Hypogonadism ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Pulsatile Administration

Effects of luteinizing hormone releasing hormone on the gonadotrophs of hypogonadal (hpg) mice

1982 ◽  
Vol 95 (3) ◽  
pp. 331-NP ◽  
Author(s):  
I. F. W. McDowell ◽  
J. F. Morris ◽  
H. M. Charlton ◽  
G. Fink
Keyword(s):  
Luteinizing Hormone ◽  
Fold Increase ◽  
Normal Range ◽  
Cell Content ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Testicular Weight ◽  
Term Administration ◽  
Lh Rh

Hypogonadal (hpg) mice lack hypothalamic luteinizing hormone releasing hormone (LH-RH); consequently the pituitary gonadotrophs, though differentiated, remain inactive. The acute and chronic responses of gonadotrophs in hpg mice to LH-RH were studied using quantitative electron microscopy, immunocytochemistry for LH and radioimmunoassay of the gonadotrophins. Acute i.v. administration of 40 ng LH-RH to male hpg mice produced an eightfold increase in plasma LH after 5 min, but granule depletion was not detectable ultrastructurally. Vacuoles (300–600 nm) were present more frequently in gonadotrophs from hpg mice given LH-RH compared with control mice. Daily s.c. administration of 2 μg LH-RH to male hpg mice for 20 days stimulated a 63-fold increase in the pituitary content of FSH but only a twofold increase in the pituitary content of LH. Testicular weight increased fivefold but the weight of the seminal vesicles did not change. The frequency of cells immunoreactive for LH increased (× 1·6), the gonadotrophs hypertrophied (× 1·9) and the cell content of granules increased (× 2·3) to values close to the normal range. The rough endoplasmic reticulum and Golgi apparatus became more prominent. A striking result of long-term daily administration of LH-RH was the accumulation of large (1–2 μm) lipid droplets in about 40% of gonadotrophs. All these changes induced by LH-RH regressed towards the untreated hpg state when LH-RH administration was discontinued for 5 and 10 days. These results show that the gonadotrophs of hpg mice can be stimulated trophically by LH-RH, and that long-term administration stimulates the synthesis and release of the gonadotrophins but the effect on FSH is much greater than on LH.

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