Results of three-times-per-week long-term administration of a luteinizing hormone-releasing hormone (LHRH) analog, d-Ser-(TBU)6-LHRH-(EA)10 in primary amenorrhea**Supported by a research grant from the National Foundation of Research, Athens, Greece.

1981 ◽  
Vol 35 (5) ◽  
pp. 515-520 ◽  
Author(s):  
Menelaos L. Batrinos ◽  
Margarita Anapliotou ◽  
Chryssoula Panitsa-Faflia ◽  
Spyros Pitoulis
Keyword(s):  
Luteinizing Hormone ◽  
Primary Amenorrhea ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
National Foundation ◽  
Term Administration ◽  
Lhrh Analog ◽  
Research Grant

Effects of luteinizing hormone releasing hormone on the gonadotrophs of hypogonadal (hpg) mice

1982 ◽  
Vol 95 (3) ◽  
pp. 331-NP ◽  
Author(s):  
I. F. W. McDowell ◽  
J. F. Morris ◽  
H. M. Charlton ◽  
G. Fink
Keyword(s):  
Luteinizing Hormone ◽  
Fold Increase ◽  
Normal Range ◽  
Cell Content ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Testicular Weight ◽  
Term Administration ◽  
Lh Rh

Hypogonadal (hpg) mice lack hypothalamic luteinizing hormone releasing hormone (LH-RH); consequently the pituitary gonadotrophs, though differentiated, remain inactive. The acute and chronic responses of gonadotrophs in hpg mice to LH-RH were studied using quantitative electron microscopy, immunocytochemistry for LH and radioimmunoassay of the gonadotrophins. Acute i.v. administration of 40 ng LH-RH to male hpg mice produced an eightfold increase in plasma LH after 5 min, but granule depletion was not detectable ultrastructurally. Vacuoles (300–600 nm) were present more frequently in gonadotrophs from hpg mice given LH-RH compared with control mice. Daily s.c. administration of 2 μg LH-RH to male hpg mice for 20 days stimulated a 63-fold increase in the pituitary content of FSH but only a twofold increase in the pituitary content of LH. Testicular weight increased fivefold but the weight of the seminal vesicles did not change. The frequency of cells immunoreactive for LH increased (× 1·6), the gonadotrophs hypertrophied (× 1·9) and the cell content of granules increased (× 2·3) to values close to the normal range. The rough endoplasmic reticulum and Golgi apparatus became more prominent. A striking result of long-term daily administration of LH-RH was the accumulation of large (1–2 μm) lipid droplets in about 40% of gonadotrophs. All these changes induced by LH-RH regressed towards the untreated hpg state when LH-RH administration was discontinued for 5 and 10 days. These results show that the gonadotrophs of hpg mice can be stimulated trophically by LH-RH, and that long-term administration stimulates the synthesis and release of the gonadotrophins but the effect on FSH is much greater than on LH.

Deficiency of gonadotropin-releasing factor in a patient with hydrocephalus internus

1975 ◽  
Vol 43 (2) ◽  
pp. 239-243 ◽  
Author(s):  
Joseph M. Coenegracht ◽  
Jan P. A. M.de Bie ◽  
Louis N. M. Coene ◽  
George Padberg
Keyword(s):  
Luteinizing Hormone ◽  
Primary Amenorrhea ◽  
Cyclic Activity ◽  
Luteinizing Hormone Releasing Hormone ◽  
Content Type ◽  
Releasing Hormone ◽  
Therapeutic Trials ◽  
Gonadotropin Releasing Factor ◽  
Fine Print

✓ The authors present the case of a 21-year-old woman with primary amenorrhea and hydrocephalus internus, and suggest that the amenorrhea was probably caused by insufficient basal and cyclic activity of luteinizing hormone/releasing hormone-producing neurons in the hypothalamus. The amenorrhea persisted after ventriculocisternotomy; only after several therapeutic trials with estrogens and progesteron did spontaneous menstrual periods appear more than 5 years after operation.

Evidence for Testicular Impairment After Long-Term Treatment with a Luteinizing Hormone-Releasing Hormone Agonist in Elderly Men

1989 ◽  
Vol 142 (5) ◽  
pp. 1235-1238 ◽  
Author(s):  
Andrea U. Decensi ◽  
Domenico Guarneri ◽  
Paola Marroni ◽  
Liborio Di Cristina ◽  
Michela Paganuzzi ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Term Treatment ◽  
Elderly Men ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Long Term Treatment ◽  
Testicular Impairment

GONADOTROPHIN RELEASE BY A HIGHLY ACTIVE ANALOGUE OF LUTEINIZING HORMONE RELEASING HORMONE IN RATS IMMUNIZED AGAINST LUTEINIZING HORMONE RELEASING HORMONE

1977 ◽  
Vol 74 (2) ◽  
pp. 291-296 ◽  
Author(s):  
H. M. FRASER ◽  
J. SANDOW
Keyword(s):  
Luteinizing Hormone ◽  
Male Rats ◽  
Tertiary Butyl ◽  
Progressive Decline ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Highly Active ◽  
Normal Rat ◽  
Lh Rh

Immunization against luteinizing hormone releasing hormone (LH-RH) in adult male rats produced a progressive decline in LH and FSH in the circulation to low or non-detectable levels. d-Serine-tertiary-butyl6,des-glycine-NH210 LH-RH ethylamide is an analogue of LH-RH having highly active LH-RH properties in the normal rat. Because it is also immunologically different from LH-RH it can stimulate gonadotrophin release from the anterior pituitary gland of rats immunized against LH-RH without interference from the antibody. The analogue stimulated LH and FSH release in rats 15 weeks after immunization against LH-RH when antibody titre was highest, and after long-term (35 weeks) immunization against LH-RH. d-Serine-tertiary-butyl6,des-glycine-NH210 LH-RH ethylamide and related analogues are therefore potentially useful for reversing the effects of immunization against LH-RH.

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