scholarly journals Polymer Nanoparticles Prepared by Supercritical Carbon Dioxide for in Vivo Anti-cancer Drug Delivery

2013 ◽  
Vol 6 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Maofang Hua ◽  
Xiufu Hua
Keyword(s):  
Carbon Dioxide ◽  
Drug Delivery ◽  
Supercritical Carbon Dioxide ◽  
Polymer Nanoparticles ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cancer Drug Delivery ◽  
Supercritical Carbon

Paclitaxel-polyurethane film for anti-cancer drug delivery: Film characterization and preliminary in vivo study

2010 ◽  
Vol 18 (7) ◽  
pp. 680-685 ◽  
Author(s):  
Sung-Gwon Kang ◽  
Se Chul Lee ◽  
Seong Hoon Choi ◽  
Sangsoo Park ◽  
Seok Jeong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vivo Study ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Polyurethane Film ◽  
Cancer Drug Delivery

Carbon Dioxide-Generating PLG Nanoparticles for Controlled Anti-Cancer Drug Delivery

2018 ◽  
Vol 35 (3) ◽  
Author(s):  
Hyeon Jin Jang ◽  
Eun Ju Jeong ◽  
Kuen Yong Lee
Keyword(s):  
Carbon Dioxide ◽  
Drug Delivery ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cancer Drug Delivery

Measuring solubility of a chemotherapy-anti cancer drug (busulfan) in supercritical carbon dioxide

2020 ◽  
Vol 317 ◽  
pp. 113954 ◽  
Author(s):  
Mahboubeh Pishnamazi ◽  
Samyar Zabihi ◽  
Sahar Jamshidian ◽  
Hoda Zeinolabedin Hezaveh ◽  
Ali Zeinolabedini Hezave ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Supercritical Carbon

scholarly journals In vivo evaluation of poly-l-asparagine nanocapsules as carriers for anti-cancer drug delivery

2013 ◽  
Vol 458 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Gustavo R. Rivera-Rodriguez ◽  
Giovanna Lollo ◽  
Tristan Montier ◽  
Jean Pierre Benoit ◽  
Catherine Passirani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
In Vivo Evaluation ◽  
Anti Cancer ◽  
Cancer Drug Delivery

scholarly journals Experimental and thermodynamic modeling decitabine anti cancer drug solubility in supercritical carbon dioxide

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mahboubeh Pishnamazi ◽  
Samyar Zabihi ◽  
Sahar Jamshidian ◽  
Fatemeh Borousan ◽  
Ali Zeinolabedini Hezave ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Solubility Data ◽  
Effect Of Temperature ◽  
Cancer Drug ◽  
Direct Relation ◽  
Anti Cancer ◽  
Temperature And Pressure ◽  
The Cross ◽  
Supercritical Carbon

AbstractDesign and development of efficient processes for continuous manufacturing of solid dosage oral formulations is of crucial importance for pharmaceutical industry in order to implement the Quality-by-Design paradigm. Supercritical solvent-based manufacturing can be utilized in pharmaceutical processing owing to its inherent operational advantages. However, in order to evaluate the possibility of supercritical processing for a particular medicine, solubility measurement needs to be carried out prior to process design. The current work reports a systematic solubility analysis on decitabine as an anti-cancer medicine. The solvent is supercritical carbon dioxide at different conditions (temperatures and pressures), while gravimetric technique is used to obtain the solubility data for decitabine. The results indicated that the solubility of decitabine varies between 2.84 × 10–05 and 1.07 × 10–03 mol fraction depending on the temperature and pressure. In the experiments, temperature and pressure varied between 308–338 K and 12–40 MPa, respectively. The solubility of decitabine was plotted against temperature and pressure, and it turned out that the solubility had direct relation with the pressure due to the effect of pressure on solvating power of solvent. The effect of temperature on solubility was shown to be dependent on the cross-over pressure. Below the cross-over pressure, there is a reverse relation between temperature and solubility, while a direct relation was observed above the cross-over pressure (16 MPa). Theoretical study was carried out to correlate the solubility data using several thermodynamic-based models. The fitting and model calibration indicated that the examined models were of linear nature and capable to predict the measured decitabine solubilities with the highest average absolute relative deviation percent (AARD %) of 8.9%.

Schiff base interaction tuned mesoporous organosilica nanoplatforms with pH-responsive degradability for efficient anti-cancer drug delivery in vivo

2018 ◽  
Vol 54 (66) ◽  
pp. 9190-9193 ◽  
Author(s):  
Lei Liu ◽  
Chao Kong ◽  
Meng Huo ◽  
Chengyu Liu ◽  
Liao Peng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Cancer Drug ◽  
Ph Responsive ◽  
Base Interaction ◽  
Tumor Ph ◽  
Mesoporous Organosilica ◽  
Anti Cancer ◽  
Cancer Drug Delivery

A drug delivery system mediated by Schiff base interaction incorporated mesoporous organosilica nanoparticles exhibits tumor/pH-responsive degradability and enhanced anti-cancer efficacy.

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