Molecular design of temperature-responsive polymers as intelligent materials

Author(s):  
Teruo Okano
2006 ◽  
Vol 53 ◽  
pp. 74-78
Author(s):  
Masayuki Yamato ◽  
Teruo Okano

In order to realize true regenerative medicine, we have developed a novel technology for the reconstruction of tissues and organs by utilizing intelligent materials including temperature-responsive polymers. We developed temperature-responsive culture surfaces, on which temperature-responsive polymers are covalently immobilized. Cells are cultured on the surfaces at 37°C, and harvested as transplantable cell sheets by reducing temperature to 20°C. With these cell sheets we regenerate various kinds of tissues such as cornea and heart.


2015 ◽  
Vol 6 (28) ◽  
pp. 5026-5029 ◽  
Author(s):  
Yasuhiro Kohsaka ◽  
Yusuke Matsumoto ◽  
Tatsuki Kitayama

Radical polymerizations of α-(aminomethyl)acrylates involved spontaneous post-polymerization modification triggered by breaking of the hydrogen bond and afforded pH/temperature responsive polymers.


2009 ◽  
Vol 20 (3) ◽  
pp. 273-279 ◽  
Author(s):  
George V. Franks ◽  
Haihong Li ◽  
John-Paul O’Shea ◽  
Greg G. Qiao

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