N-methyl-d-aspartate receptor subunit mRNA expression in human retinal ganglion cells

2000 ◽  
Vol 238 (6) ◽  
pp. 486-490 ◽  
Author(s):  
W. A. Lagrèze ◽  
Melanie Darstein ◽  
Thomas J. Feuerstein ◽  
T. Otto ◽  
G. Bernhard Landwehrmeyer
Keyword(s):  
Mrna Expression ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Receptor Subunit ◽  
Subunit Mrna ◽  
Aspartate Receptor

scholarly journals The Role of N-Methyl-D-Aspartate Receptor Activation in Homocysteine-Induced Death of Retinal Ganglion Cells

2011 ◽  
Vol 52 (8) ◽  
pp. 5515 ◽  
Author(s):  
Preethi S. Ganapathy ◽  
Richard E. White ◽  
Yonju Ha ◽  
B. Renee Bozard ◽  
Paul L. McNeil ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Receptor Activation ◽  
Retinal Ganglion ◽  
Aspartate Receptor

Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells

2005 ◽  
Vol 22 (12) ◽  
pp. 3129-3136 ◽  
Author(s):  
Katsuhiko Sakamoto ◽  
Cuimei Liu ◽  
Manami Kasamatsu ◽  
Nikita V. Pozdeyev ◽  
P. Michael Iuvone ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion

scholarly journals Norrin Protects Retinal Ganglion Cells from Excitotoxic Damage via the Induction of Leukemia Inhibitory Factor

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 277 ◽  
Author(s):  
Stefan Kassumeh ◽  
Stephanie Leopold ◽  
Rudolf Fuchshofer ◽  
Carina N. Thomas ◽  
Siegfried G. Priglinger ◽  
...  
Keyword(s):  
Protective Factors ◽  
Mrna Expression ◽  
Retinal Ganglion Cells ◽  
Leukemia Inhibitory Factor ◽  
Ganglion Cells ◽  
Inhibitory Factor ◽  
Retinal Ganglion ◽  
Wild Type ◽  
Excitotoxic Damage ◽  
Deficient Mice

Purpose: To investigate whether and how leukemia inhibitory factor (Lif) is involved in mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following excitotoxic damage. Norrin is a secreted protein that protects RGC from N-methyl-d-aspartate (NMDA)-mediated excitotoxic damage, which is accompanied by increased expression of protective factors such as Lif, Edn2 and Fgf2. Methods: Lif-deficient mice were injected with NMDA in one eye and NMDA plus Norrin into the other eye. RGC damage was investigated and quantified by TUNEL labeling 24 h after injection. Retinal mRNA expression was analyzed by quantitative real-time polymerase chain reaction following retinal treatment. Results: After intravitreal injection of NMDA and Norrin in wild-type mice approximately 50% less TUNEL positive cells were observed in the RGC layer when compared to NMDA-treated littermates, an effect which was lost in Lif-deficient mice. The mRNA expression for Gfap, a marker for Müller cell gliosis, as well as Edn2 and Fgf2 was induced in wild-type mice following NMDA/Norrin treatment but substantially blocked in Lif-deficient mice. Conclusions: Norrin mediates its protective properties on RGC via Lif, which is required to enhance Müller cell gliosis and to induce protective factors such as Edn2 or Fgf2.

Alterations in N-Methyl-D-Aspartate Receptor Subunit mRNA Expression Levels in Cerebral Cortex in Kindling-Induced Epileptogenesis.

Epilepsia ◽  
1996 ◽  
Vol 37 (s3) ◽  
pp. 113-114 ◽  
Author(s):  
Shuichi Kikuchi ◽  
Hiroto Iwasa ◽  
Nobuya Inagaki ◽  
Kaori Suzuki ◽  
Toshio Sato ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Mrna Expression ◽  
Receptor Subunit ◽  
Expression Levels ◽  
Subunit Mrna ◽  
Aspartate Receptor ◽  
Mrna Expression Levels
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