scholarly journals Marked increase in beta-tubulin mRNA expression during regeneration of axotomized retinal ganglion cells in adult mammals

1993 ◽  
Vol 13 (12) ◽  
pp. 5294-5300 ◽  
Author(s):  
L McKerracher ◽  
C Essagian ◽  
AJ Aguayo
Keyword(s):  
Mrna Expression ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Beta Tubulin ◽  
Tubulin Mrna

N-methyl-d-aspartate receptor subunit mRNA expression in human retinal ganglion cells

2000 ◽  
Vol 238 (6) ◽  
pp. 486-490 ◽  
Author(s):  
W. A. Lagrèze ◽  
Melanie Darstein ◽  
Thomas J. Feuerstein ◽  
T. Otto ◽  
G. Bernhard Landwehrmeyer
Keyword(s):  
Mrna Expression ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Receptor Subunit ◽  
Subunit Mrna ◽  
Aspartate Receptor

Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells

2005 ◽  
Vol 22 (12) ◽  
pp. 3129-3136 ◽  
Author(s):  
Katsuhiko Sakamoto ◽  
Cuimei Liu ◽  
Manami Kasamatsu ◽  
Nikita V. Pozdeyev ◽  
P. Michael Iuvone ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion

scholarly journals Norrin Protects Retinal Ganglion Cells from Excitotoxic Damage via the Induction of Leukemia Inhibitory Factor

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 277 ◽  
Author(s):  
Stefan Kassumeh ◽  
Stephanie Leopold ◽  
Rudolf Fuchshofer ◽  
Carina N. Thomas ◽  
Siegfried G. Priglinger ◽  
...  
Keyword(s):  
Protective Factors ◽  
Mrna Expression ◽  
Retinal Ganglion Cells ◽  
Leukemia Inhibitory Factor ◽  
Ganglion Cells ◽  
Inhibitory Factor ◽  
Retinal Ganglion ◽  
Wild Type ◽  
Excitotoxic Damage ◽  
Deficient Mice

Purpose: To investigate whether and how leukemia inhibitory factor (Lif) is involved in mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following excitotoxic damage. Norrin is a secreted protein that protects RGC from N-methyl-d-aspartate (NMDA)-mediated excitotoxic damage, which is accompanied by increased expression of protective factors such as Lif, Edn2 and Fgf2. Methods: Lif-deficient mice were injected with NMDA in one eye and NMDA plus Norrin into the other eye. RGC damage was investigated and quantified by TUNEL labeling 24 h after injection. Retinal mRNA expression was analyzed by quantitative real-time polymerase chain reaction following retinal treatment. Results: After intravitreal injection of NMDA and Norrin in wild-type mice approximately 50% less TUNEL positive cells were observed in the RGC layer when compared to NMDA-treated littermates, an effect which was lost in Lif-deficient mice. The mRNA expression for Gfap, a marker for Müller cell gliosis, as well as Edn2 and Fgf2 was induced in wild-type mice following NMDA/Norrin treatment but substantially blocked in Lif-deficient mice. Conclusions: Norrin mediates its protective properties on RGC via Lif, which is required to enhance Müller cell gliosis and to induce protective factors such as Edn2 or Fgf2.

Calcium Signals Induced By Tonic Firing In Rat Retinal Ganglion Cells

2012 ◽  
Vol 3 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Kyril I. Kuznetsov ◽  
Vitaliy Yu. Maslov ◽  
Svetlana A. Fedulova ◽  
Nikolai S. Veselovsky
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Calcium Signals ◽  
Tonic Firing
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