1,4-Disubstituted-5-hydroxy-3-methylpyrazoles and some derived ring systems as cytotoxic and DNA binding agents. Synthesis, in vitro biological evaluation and in silico ADME study

2017 ◽  
Vol 27 (2) ◽  
pp. 442-457
Author(s):  
Mona Hany Badr ◽  
Heba Attia Abd El Razik
Keyword(s):  
Dna Binding ◽  
In Silico ◽  
Biological Evaluation ◽  
Ring Systems ◽  
Binding Agents ◽  
Dna Binding Agents ◽  
Adme Study

scholarly journals in vitro Screening of N-Naphthylhydroxamic Acids as DNA Binding Agents

2016 ◽  
Vol 28 (12) ◽  
pp. 2605-2612 ◽  
Author(s):  
Manish Pardhi ◽  
Bharati Verma ◽  
Yamini Thakur ◽  
Rubi Khilari ◽  
Mamta Tripathi ◽  
...  
Keyword(s):  
Dna Binding ◽  
In Vitro Screening ◽  
Binding Agents ◽  
Dna Binding Agents

Diversification of quinoline-triazole scaffolds with CORMs: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum

2021 ◽  
Vol 215 ◽  
pp. 111328
Author(s):  
Fatima-Zahra Ishmail ◽  
Diana R. Melis ◽  
Mziyanda Mbaba ◽  
Gregory S. Smith
Keyword(s):  
Plasmodium Falciparum ◽  
In Silico ◽  
Biological Evaluation

Binding mode and affinity studies of DNA-binding agents using topoisomerase I DNA unwinding assay

2007 ◽  
Vol 17 (4) ◽  
pp. 1013-1017 ◽  
Author(s):  
Ruel E. McKnight ◽  
Aaron B. Gleason ◽  
James A. Keyes ◽  
Sadia Sahabi
Keyword(s):  
Dna Binding ◽  
Topoisomerase I ◽  
Binding Mode ◽  
Dna Unwinding ◽  
Binding Agents ◽  
Dna Binding Agents

scholarly journals Synthesis of Novel Pyrazole Derivatives as Promising DNA-Binding Agents and Evaluation of Antitumor and Antitopoisomerases I/II Activities

2018 ◽  
Vol 66 (11) ◽  
pp. 1065-1071 ◽  
Author(s):  
Jiajia Feng ◽  
Hui Qi ◽  
Xiaoyang Sun ◽  
Siran Feng ◽  
Zhenming Liu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Pyrazole Derivatives ◽  
Binding Agents ◽  
Dna Binding Agents

Dihydroimidazophenanthridinium (DIP)-Based DNA Binding Agents with Tuneable Structures and Biological Activity

ChemBioChem ◽  
2006 ◽  
Vol 7 (11) ◽  
pp. 1757-1763 ◽  
Author(s):  
Louise V. Smith ◽  
Alexis D. C. Parenty ◽  
Kevin M. Guthrie ◽  
Jane Plumb ◽  
Robert Brown ◽  
...  
Keyword(s):  
Biological Activity ◽  
Dna Binding ◽  
Binding Agents ◽  
Dna Binding Agents

Polyethylene glycol-bonded triethylammonium l-prolinate: a new biodegradable amino-acid-based ionic liquid for the one-pot synthesis of bis(pyrazolyl)methanes as DNA binding agents

2020 ◽  
Vol 44 (39) ◽  
pp. 16995-17012
Author(s):  
Reza Kordnezhadian ◽  
Mohsen Shekouhy ◽  
Somaye Karimian ◽  
Zohreh Tavaf ◽  
Saeed Malek-Hosseini ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Polyethylene Glycol ◽  
Amino Acid ◽  
Dna Binding ◽  
One Pot ◽  
One Pot Synthesis ◽  
Binding Agents ◽  
Dna Binding Agents ◽  
The One

[PEG-TEA]LP, as a new biodegradable ionic liquid catalyst, was successfully synthesized, characterized, and applied to the one-pot pseudo-five-component synthesis of bis(pyrazolyl)methanes.

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