scholarly journals Erratum to: Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets

Diabetologia ◽  
2009 ◽  
Vol 53 (2) ◽  
pp. 396-396
Author(s):  
J. Olerud ◽  
N. Kanaykina ◽  
S. Vasylovska ◽  
D. King ◽  
M. Sandberg ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Beta Cell ◽  
Neural Crest ◽  
Pancreatic Islets ◽  
Beta Cell Proliferation ◽  
Islet Function ◽  
Neural Crest Stem Cells

scholarly journals Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets

Diabetologia ◽  
2009 ◽  
Vol 52 (12) ◽  
pp. 2594-2601 ◽  
Author(s):  
J. Olerud ◽  
N. Kanaykina ◽  
S. Vasilovska ◽  
D. King ◽  
M. Sandberg ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Beta Cell ◽  
Neural Crest ◽  
Pancreatic Islets ◽  
Beta Cell Proliferation ◽  
Islet Function ◽  
Neural Crest Stem Cells

scholarly journals Co-transplantation of Human Pancreatic Islets With Post-migratory Neural Crest Stem Cells Increases β-Cell Proliferation and Vascular And Neural Regrowth

2015 ◽  
Vol 100 (4) ◽  
pp. E583-E590 ◽  
Author(s):  
Liza Grapensparr ◽  
Svitlana Vasylovska ◽  
Zhanchun Li ◽  
Johan Olerud ◽  
Leif Jansson ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Neural Crest ◽  
Pancreatic Islets ◽  
Β Cell ◽  
Neural Crest Stem Cells ◽  
Human Pancreatic Islets

scholarly journals High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets

2022 ◽  
Author(s):  
Hannah J MacMillan ◽  
Yahui Kong ◽  
Ezequiel Calvo-Roitberg ◽  
Laura C Alonso ◽  
Athma A Pai
Keyword(s):  
Cell Proliferation ◽  
Beta Cell ◽  
Pancreatic Islets ◽  
Molecular Mechanisms ◽  
Circular Rna ◽  
Beta Cell Proliferation ◽  
High Throughput Analysis ◽  
Exon 2 ◽  
Human Pancreatic Islets ◽  
Protective Allele

The antisense non-coding RNA in the INK locus (ANRIL) is a hotspot for genetic variants associated with cardiometabolic disease. We recently found increased ANRIL abundance in human pancreatic islets from donors with certain Type II Diabetes (T2D) risk-SNPs, including a T2D risk-SNP located within ANRIL exon 2 associated with beta cell proliferation. Recent studies have found that expression of circular species of ANRIL is linked to the regulation of cardiovascular phenotypes. Less is known about how the abundance of circular ANRIL may influence T2D phenotypes. Herein, we sequence circular RNA in pancreatic islets to characterize circular isoforms of ANRIL. We identify highly expressed circular ANRIL isoforms whose expression is correlated across dozens of individuals and characterize ANRIL splice sites that are commonly involved in back-splicing. We find that samples with the T2D risk allele in ANRIL exon 2 had higher ratios of circular to linear ANRIL compared to protective-allele carriers, and that higher circular:linear ANRIL was associated with decreased beta cell proliferation. Our study points to a combined involvement of both linear and circular ANRIL species in T2D phenotypes and opens the door for future studies of the molecular mechanisms by which ANRIL impacts cellular function in pancreatic islets.

scholarly journals Surface Coating of Pancreatic Islets with Neural Crest Stem Cells Improves Engraftment and Function after Intraportal Transplantation

2015 ◽  
Vol 24 (11) ◽  
pp. 2263-2272 ◽  
Author(s):  
Joey Lau ◽  
Svitlana Vasylovska ◽  
Elena N. Kozlova ◽  
Per-Ola Carlsson
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Pancreatic Islets ◽  
Surface Coating ◽  
Neural Crest Stem Cells ◽  
And Function

13 - RGS9 Is Required for Glucose-Induced Beta-Cell Proliferation in Ex Vivo Pancreatic Islets

2020 ◽  
Vol 44 (7) ◽  
pp. S6
Author(s):  
Scott A. Campbell ◽  
Anais Szpigel ◽  
Caroline Tremblay ◽  
Julien Ghislain ◽  
Vincent Poitout
Keyword(s):  
Cell Proliferation ◽  
Beta Cell ◽  
Pancreatic Islets ◽  
Ex Vivo ◽  
Beta Cell Proliferation

scholarly journals Co-Culture of Neural Crest Stem Cells (NCSC) and Insulin Producing Beta-TC6 Cells Results in Cadherin Junctions and Protection against Cytokine-Induced Beta-Cell Death

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61828 ◽  
Author(s):  
Anongnad Ngamjariyawat ◽  
Kyril Turpaev ◽  
Svitlana Vasylovska ◽  
Elena N. Kozlova ◽  
Nils Welsh
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Beta Cell ◽  
Neural Crest ◽  
Beta Cell Death ◽  
Neural Crest Stem Cells
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