scholarly journals Mortality after cancer among patients with diabetes mellitus: effect of diabetes duration and treatment

Diabetologia ◽  
2014 ◽  
Vol 57 (5) ◽  
pp. 927-934 ◽  
Author(s):  
Kristina Ranc ◽  
Marit E. Jørgensen ◽  
Søren Friis ◽  
Bendix Carstensen
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Duration ◽  
Patients With Diabetes ◽  
After Cancer

scholarly journals Induction and maintenance of remission of insulin-dependent diabetes mellitus in repeated courses of hyperbaric oxygenation

1999 ◽  
Vol 45 (4) ◽  
pp. 10-13
Author(s):  
A. V. Dreval ◽  
V. A. Gubkina ◽  
S. O. Kiselev ◽  
R. S. Tishenin ◽  
G. S. Molchanov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Hyperbaric Oxygenation ◽  
Insulin Dependent Diabetes Mellitus ◽  
Diabetes Remission ◽  
Diabetes Duration ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Patients With Diabetes ◽  
Insulin Dependent

The efficacy of hyperbaric oxygenation (HBO) is studied in diabetics with newly detected or lasting for less than 1 year disease. The possibility of inducing and/or prolonging diabetes remission by HBO and the efficacy of repeated courses of HBO are evaluated. Fifty-three patients with insulin-dependent diabetes mellitus (IDDM) (28 men and 25 women) aged 15-39 years, suffering from the disease for up to 12 month without apparent complications, were administered intensive insulin therapy with human insulin preparations and 10-day HBO courses. HBO courses repeated every 4 months promoted compensation of carbohydrate metabolism by stimulating residual insulin secretion in patients with IDDM lasting for up to one year, the effect of HBO progressively decreasing with each course. Manifest positive effect of HBO persisted for 2 months. After the first course of HBO, remission of IDDM ensued in 41.5% cases. Patients aged over 25 years with intact insulin secretion on an empty stomach were more disposed to remission. Remissions were equally incident in patients with diabetes duration of up to 6 months and in those with diabetes duration of 6-12 months. A history of ketoacidotic coma episodes does not rule out the induction of a remission.

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

Desmopressin Stimulates Parallel Norepinephrine and Tissue Plasminogen Activator Release in Normal Subjects and Patients with Diabetes Mellitus

1988 ◽  
Vol 59 (02) ◽  
pp. 269-272 ◽  
Author(s):  
M B Grant ◽  
C Guay ◽  
R Lottenberg
Keyword(s):  
Diabetes Mellitus ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Time Course ◽  
Vascular Endothelial Cells ◽  
Normal Subjects ◽  
Plasma Norepinephrine ◽  
Endogenous Catecholamine ◽  
Tissue Plasminogen ◽  
Patients With Diabetes

SummaryDesmopressin acetate administration markedly stimulates release of tissue plasminogen activator (t-PA) from vascular endothelial cells. The mechanism for this effect is unknown. Because infusion of epinephrine has been shown to increase t-PA levels, we examined the role of endogenous catecholamine mediation of t-PA release by desmopressin. Intravenous desmopressin acetate (0.3 μg/kg) was infused over 30 min in 9 controls and 11 subjects with diabetes mellitus, a condition associated with abnormalities of the fibrinolytic system. Plasma was collected in the supine, overnight fasted state at 15 min intervals (0-60 min) for measurement of t-PA activity, t-PA antigen and fractionated catecholamines. t-PA activity peaked at 30-45 min and subsequently decreased. The norepinephrine levels paralleled the t-PA activity. t-PA activity increased 10-fold from 0.14 ± .12 to 1.49 ± 0.79 IU/ml (Mean ± SD) and plasma norepinephrine increased 2- fold from 426 ± 90 to 780 ± 292 pg/ml. However, epinephrine and dopamine levels did not change significantly. The response to desmopressin of control and diabetic subjects was not shown to differ and their data were combined. We conclude that desmopressin increases plasma norepinephrine in addition to t-PA and that the parallel time course of change suggests a possible role for norepinephrine in mediating endothelial cell t-PA release.

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