scholarly journals A novel expiratory circuit for recovery of perfluorocarbon liquid during partial liquid ventilation

2003 ◽  
Vol 30 (3) ◽  
pp. 514-516 ◽  
Author(s):  
Kimble Robert Dunster ◽  
Mark William Davies
Keyword(s):  
Partial Liquid Ventilation ◽  
Perfluorocarbon Liquid ◽  
Liquid Ventilation

Perfluorochemical Liquid Ventilation: From the Animal Laboratory to the Intensive Care Unit

1995 ◽  
Vol 18 (10) ◽  
pp. 674-683 ◽  
Author(s):  
P.L.J. Degraeuwe ◽  
G. D. Vos ◽  
C. E. Blanco
Keyword(s):  
Functional Residual Capacity ◽  
Hyaline Membrane Disease ◽  
Lung Mechanics ◽  
Partial Liquid Ventilation ◽  
Perfluorocarbon Liquid ◽  
Liquid Ventilation ◽  
Pilot Studies ◽  
Important Place ◽  
Restrictive Lung Disease ◽  
Residual Capacity

Perfluorochemical or perfluorocarbon liquids have an enormous gas-carrying capacity. During tidal liquid ventilation the respiratory medium of both functional residual capacity and tidal volume is replaced by neat perfluorocarbon liquid. Tidal liquid ventilation is characterized by convective and diffusive limitations, but offers the advantage of preserved functional residual capacity, high compliance and improved ventilation-perfusion matching. During partial liquid ventilation only the functional residual capacity is replaced by perfluorocarbon liquid. Both tidal and partial liquid ventilation improve gas exchange and lung mechanics in hyaline membrane disease, adult respiratory distress models and meconium aspiration. Compared to gas ventilation, there is less histologic evidence of barotrauma after liquid ventilation. Cardio-pulmonary interaction, inherent to the high density of liquid, and long term safety need further study. However, extrapolating from animal data, and taking into account promising human pilot studies, liquid ventilation has the desired properties to occupy an important place in the therapy of restrictive lung disease in man.

VAPORIZED PERFLUOROHEXANE VS. PARTIAL LIQUID VENTILATION IN EXPERIMENTAL LUNG INJURY

ASAIO Journal ◽  
2006 ◽  
Vol 52 (4) ◽  
pp. 491
Author(s):  
Marcelo Gama de Abreu ◽  
Andr?? Domingues Quelhas ◽  
Peter Spieth ◽  
G??tz Br??uer ◽  
Lilla Knels ◽  
...  
Keyword(s):  
Lung Injury ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation

scholarly journals Pulmonary Stretch Receptor Activity during Partial Liquid Ventilation in Cats with Healthy Lungs

Neonatology ◽  
2004 ◽  
Vol 86 (2) ◽  
pp. 73-80 ◽  
Author(s):  
Esther Rieger-Fackeldey ◽  
Richard Sindelar ◽  
Anders Jonzon ◽  
Andreas Schulze ◽  
Gunnar Sedin
Keyword(s):  
Stretch Receptor ◽  
Receptor Activity ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation ◽  
Pulmonary Stretch Receptor

Intratracheal perfluorocarbons diminish LPS-induced increase in systemic TNF-α

2008 ◽  
Vol 294 (6) ◽  
pp. L1043-L1048 ◽  
Author(s):  
Wolfram Burkhardt ◽  
Petra Koehne ◽  
Heide Wissel ◽  
Susanne Graf ◽  
Hans Proquitté ◽  
...  
Keyword(s):  
Histological Evaluation ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Spontaneously Breathing ◽  
Lower Expression ◽  
Mechanical Barrier ◽  
Low Serum ◽  
Inflammatory Effect

Perfluorocarbons (PFC) reduce the production of various inflammatory cytokines, including TNF-α. The anti-inflammatory effect is not entirely understood. If anti-inflammatory properties are caused by a mechanical barrier, PFC in the alveoli should have no effect on the inflammatory response to intravenous LPS administration. To test that hypothesis, rats ( n = 31) were administered LPS intravenously and were either spontaneously breathing (Spont), conventionally ventilated (CMV), or receiving partial liquid ventilation (PLV). Serum concentration of TNF-α was measured. The pulmonary expressions of TNF-α and TNF-α receptor 1 protein and of TNF-α and ICAM-1 mRNA were determined. LPS caused a significant ( P < 0.001) increase in serum TNF-α. Serum TNF-α concentration was similar in LPS/Spont (525 ± 180 pg/ml) and LPS/CMV (504 ± 154 pg/ml) but was significantly ( P < 0.001) lower in animals of the LPS/PLV group (274 ± 101 pg/ml). Immunohistochemical data on TNF-α protein expression showed a LPS-induced increase in TNF-α and TNF-α receptor 1 expression that was diminished by partial liquid ventilation. PCR measurements revealed a lower expression of TNF-α and ICAM-1 mRNA in LPS/PLV than in LPS/CMV or LPS/Spont animals. Semiquantitative histological evaluation revealed only minor alveolar inflammation with no significant differences between the groups. Low serum TNF-α concentration in PFC-treated animals is most likely explained by a decreased production of TNF-α in the lung.

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