Timing of low bone mineral density and predictors of bone mineral density trajectory in children on long-term warfarin: a longitudinal study

2015 ◽  
Vol 27 (4) ◽  
pp. 1547-1557 ◽  
Author(s):  
M. L. Avila ◽  
E. Pullenayegum ◽  
S. Williams ◽  
A. Shammas ◽  
J. Stimec ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Longitudinal Study ◽  
Bone Mineral ◽  
Mineral Density ◽  
Low Bone Mineral Density

The Risk of Low Bone Mineral Density with Long-Term G-CSF Therapy for Severe Chronic Neutropenia.

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1484-1484 ◽  
Author(s):  
L. A. DiMeglio ◽  
Audrey Anna Bolyard ◽  
Tracy M. Marrero ◽  
Blanche P Alter ◽  
Mary Ann Bonilla ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Sufficient Information ◽  
Z Score ◽  
Mineral Density ◽  
Cyclic Neutropenia ◽  
T Score ◽  
Low Bone Mineral Density ◽  
Chronic Neutropenia

Abstract Abstract 1484 Low bone mineral density (BMD) is a known risk factor for fractures. Low BMD has been reported in individuals with severe chronic neutropenia (SCN), and attributed both to the diseases causing neutropenia and to G-CSF therapy. However, given the rarity of SCN, few data exist regarding associations of BMD z-scores with disease characteristics such as type of neutropenia and duration of G-CSF therapy. We present data here obtained from BMD reports collected through the Severe Chronic Neutropenia International Registry (SCNIR). We reviewed BMDs on 128 subjects [40 children (< 21 years of age), 87 females] having sufficient information about lumbar spine BMD by dual-xray absorptiometry (DXA) for evaluation. For subjects with multiple BMD measurements available, the most recent one was used for analysis. Mean age was 32.0 years (range 0.6–85 years). 57 subjects had idiopathic SCN (mean age 40 years), 40 had congenital (mean age 15 years), 28 were cyclic (mean age 41 years) and 3 were autoimmune (mean age 18 years). 122 subjects had received G-CSF at the time of the BMD assessment (mean 8.8 years, range 0.1–19.9 years). 11 of the adults were on bisphosphonate therapy for low BMD at the time of the BMD assessment; no children were on anti-resorptive therapy. BMDs in these subjects were, on average, low. For the children, the BMD z-score (age matched mean ±1 standard deviation) was -1.0 ± 1.1, with 17.5% of children having BMDs that were low for age (Z-score < -2.0). For the adults the BMD t-score was -1.1 ± 1.4, with 46% of adults meeting t-score criteria for osteopenia (≤ -1.0) and 9% meeting criteria for osteoporosis (< -2.5). BMDs were lowest in those with congenital neutropenia, followed by those with cyclic neutropenia. For children, BMDs were lower in those who had received longer G-CSF therapy (r= -0.506, p=0.002). This association was not seen in adults (r= 0.074, p= 0.5). The low BMDs and the correlation of lower BMD with longer G-CSF treatment in children suggests there is an association of bone loss with the childhood diseases causing SCN. The data also suggest that regular assessments of bone health should be made in SCN patients, particularly those on long-term G-CSF therapy. Disclosures: Boxer: Amgen, Inc.: Equity Ownership. Dale:Amgen: Consultancy, Research Funding.

Long-term longitudinal study of bone mineral density in hemodialysis and renal transplanation

Bone ◽  
1993 ◽  
Vol 14 (1) ◽  
pp. 83
Author(s):  
R. Alanso ◽  
X.M. Lens ◽  
E. Del Río ◽  
J.M. Fraga ◽  
D. Sánchez-Quisande
Keyword(s):  
Bone Mineral Density ◽  
Longitudinal Study ◽  
Bone Mineral ◽  
Mineral Density

Low bone mineral density (BMD) in Crohns disease (CD) is associated with long term use of glucocorticoids

1999 ◽  
Vol 11 (12) ◽  
pp. A1
Author(s):  
D. J. de Long ◽  
L. Mannaerts ◽  
L. Rossum ◽  
F. M.H. Corstens ◽  
A. H.J. Naber
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Crohns Disease ◽  
Low Bone Mineral Density

scholarly journals Impaired Vestibular Function and Low Bone Mineral Density: Data from the Baltimore Longitudinal Study of Aging

2016 ◽  
Vol 17 (5) ◽  
pp. 433-440 ◽  
Author(s):  
Robin T Bigelow ◽  
Yevgeniy R Semenov ◽  
Eric Anson ◽  
Sascha du Lac ◽  
Luigi Ferrucci ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Longitudinal Study ◽  
Bone Mineral ◽  
Vestibular Function ◽  
Mineral Density ◽  
Density Data ◽  
Low Bone Mineral Density ◽  
Baltimore Longitudinal Study

Long-Term Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density: a 4-Year Longitudinal Study

2020 ◽  
Vol 30 (9) ◽  
pp. 3317-3325 ◽  
Author(s):  
O. Cadart ◽  
O. Degrandi ◽  
T. Barnetche ◽  
N. Mehsen-Cetre ◽  
M. Monsaingeon-Henry ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Longitudinal Study ◽  
Bone Mineral ◽  
Long Term Effects ◽  
Mineral Density
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