The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver

Archives of Toxicology ◽

10.1007/s00204-019-02488-5 ◽

2019 ◽

Vol 93 (7) ◽

pp. 1917-1926 ◽

Author(s):

Melina Mescher ◽

Julia Tigges ◽

Katharina M. Rolfes ◽

Anna L. Shen ◽

Jeremiah S. Yee ◽

...

Keyword(s):

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Mouse Liver ◽

Receptor Agonist ◽

Human Keratinocytes ◽

Toll Like Receptor ◽

Cytochrome P450 Enzymes ◽

Aryl Hydrocarbon

Download Full-text

Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells

Biochemical Pharmacology ◽

10.1016/s0006-2952(98)00208-1 ◽

1998 ◽

Vol 56 (5) ◽

pp. 599-612 ◽

Author(s):

Wei Li ◽

Patricia A Harper ◽

Bing-Kou Tang ◽

Allan B Okey

Keyword(s):

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Human Cells ◽

Cytochrome P450 Enzymes ◽

Aryl Hydrocarbon

Download Full-text

Cooperative Regulation of Expression of Cytochrome P450 Enzymes by Aryl Hydrocarbon Receptor and Vitamin D Receptor

Fifty Years of Cytochrome P450 Research ◽

10.1007/978-4-431-54992-5_16 ◽

2014 ◽

pp. 277-290

Author(s):

Makoto Makishima

Keyword(s):

Vitamin D ◽

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Vitamin D Receptor ◽

Cytochrome P450 Enzymes ◽

Regulation Of Expression ◽

Aryl Hydrocarbon

Download Full-text

Coordinate Regulation of Cytochrome P450 1A1 Expression in Mouse Liver by the Aryl Hydrocarbon Receptor and the β-Catenin Pathway

Toxicological Sciences ◽

10.1093/toxsci/kfr080 ◽

2011 ◽

Vol 122 (1) ◽

pp. 16-25 ◽

Author(s):

Albert Braeuning ◽

Christoph Köhle ◽

Albrecht Buchmann ◽

Michael Schwarz

Keyword(s):

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Mouse Liver ◽

Cytochrome P450 1A1 ◽

Coordinate Regulation ◽

Aryl Hydrocarbon

Download Full-text

The Role of Aryl Hydrocarbon Receptor-Regulated Cytochrome P450 Enzymes in Glioma

Current Pharmaceutical Design ◽

10.2174/13816128113199990583 ◽

2013 ◽

Vol 19 (40) ◽

pp. 7155-7166 ◽

Author(s):

Hesham Korashy ◽

Hatim Abuohashish ◽

Zaid Maayah

Keyword(s):

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Cytochrome P450 Enzymes ◽

Aryl Hydrocarbon

Download Full-text

Cytochrome P450 expression in human keratinocytes: an aryl hydrocarbon receptor perspective

Chemico-Biological Interactions ◽

10.1016/j.cbi.2004.08.006 ◽

2004 ◽

Vol 149 (2-3) ◽

pp. 69-79 ◽

Author(s):

Hollie I. Swanson

Keyword(s):

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Human Keratinocytes ◽

Aryl Hydrocarbon ◽

P450 Expression

Download Full-text

Species difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126

Xenobiotica ◽

10.3109/00498254.2011.603763 ◽

2011 ◽

Vol 41 (12) ◽

pp. 1031-1043 ◽

Author(s):

Bingxuan Wang ◽

Larry W. Robertson ◽

Kai Wang ◽

Gabriele Ludewig

Keyword(s):

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Receptor Agonist ◽

Species Difference ◽

Aryl Hydrocarbon ◽

Aryl Hydrocarbon Receptor Agonist

Download Full-text

Faculty Opinions recommendation of Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718529695.793498699 ◽

2014 ◽

Author(s):

Santosh Kumar

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Receptor Agonist ◽

Aryl Hydrocarbon ◽

Pcb 126 ◽

Aryl Hydrocarbon Receptor Agonist ◽

Cyp1a1 Induction

Download Full-text

Biomimetic Synthesis and Analytics of the Human aryl Hydrocarbon Receptor Agonist 1-(furan-2-yl)-2-(1H-indol-3-yl)ethanone, and its 1-(thiophen-2-yl) and 1- (pyrrol-2-yl) Analogues

Current Organic Chemistry ◽

10.2174/13852728113179990026 ◽

2013 ◽

Vol 17 (20) ◽

pp. 2349-2358 ◽

Author(s):

Martina Opietnik ◽

Kurt Mereiter ◽

Paul Kosma ◽

Alois Jungbauer ◽

Thomas Rosenau

Keyword(s):

Aryl Hydrocarbon Receptor ◽

Receptor Agonist ◽

Biomimetic Synthesis ◽

Aryl Hydrocarbon ◽

Aryl Hydrocarbon Receptor Agonist

Download Full-text

Downregulation of aryl hydrocarbon receptor function and cytochrome P450 1A1 induction by expression of ha-ras oncogenes

Molecular Carcinogenesis ◽

10.1002/(sici)1098-2744(199707)19:2<91::aid-mc4>3.0.co;2-o ◽

1997 ◽

Vol 19 (2) ◽

pp. 91-100 ◽

Author(s):

John J. Reiners ◽

Carol L. Jones ◽

Nancy Hong ◽

Russell E. Clift ◽

Cornelius Elferink

Keyword(s):

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Receptor Function ◽

Cytochrome P450 1A1 ◽

Aryl Hydrocarbon ◽

Download Full-text

The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor

Archives of Toxicology ◽

10.1007/s00204-011-0781-3 ◽

2011 ◽

Vol 86 (4) ◽

pp. 625-632 ◽

Author(s):

Ilona Schreck ◽

Ute Deigendesch ◽

Britta Burkhardt ◽

Doris Marko ◽

Carsten Weiss

Keyword(s):

Cytochrome P450 ◽

Aryl Hydrocarbon Receptor ◽

Methyl Ether ◽

Hepatoma Cells ◽

Cytochrome P450 1A1 ◽

Alternariol Methyl Ether ◽

Aryl Hydrocarbon ◽

Alternaria Mycotoxins

Download Full-text