Comment on “Genetic toxicology and toxicokinetics of arecoline and related areca nut compounds: an updated review”

Guwahati derives its name from the Assamese word “Guwa” means areca nut and “Haat” means market. However, the modern Guwahati had been known as the ancient Pragjyotishpura and was the capital of Assam under the Kamrupa kingdom. A beautiful city Guwahati is situated on the south bank of the river Bramhaputra. Moreover, It is known as the largest city in the Indian state of Assam and also the largest metropolis in North East India. It has also its importance as the gateway to the North- East India. Assamese and English are the spoken languages in Guwahati. In 1667, the Mogul forces were defeated in the battle by the Ahom forces commanded by Lachut Barphukan. Thus, in a sense Guwahati became the bone of contention among the Ahoms, Kochas and the Moguls during the medieval period. Guwahati the administrative headquarters of Lower Assam with a viceroy or Barbhukan was made by the Ahom king. Since 1972 it has been the capital of Assam. The present paper will discuss the changes happened in Guwahati over the period of late 1970s till the present time. It will focus on the behavior of people, transformed temples, Panbazar of the city, river bank of Bramhaputra, old Fancy Bazaar, chaotic ways, festivals and seasons including a fifth man made season etc. It will also deal how over the years a city endowed with nature’s gifts and scenic views, has been changing as “a dirty city”. Furthermore, it will also present the insurgencies that have barged into the city. The occurrence of changes will be discussed through the perspective and point of view of Srutimala Duara as presented in her book Mindprints of Guwahati.

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PRODUCTION OF LIGNOCELLULOSES FROM ASPERGILLUS NIGER USING ARECA NUT SPADE AS BIOMASS..

10.36106/ijsr/1515973 ◽

2019 ◽

pp. 1-3

Author(s):

Madhuri B ◽

Narasimha G ◽

Balaji M*

Keyword(s):

Solid State ◽

Aspergillus Niger ◽

Cellulase Production ◽

Areca Nut ◽

Physical Treatment ◽

Cellulose Production ◽

Lactobionic Acid ◽

Cellulase Enzyme

Areca palm (ChrysalidoCarpus lutescenes) a widely used plant having feathery arching brands with 100 leaflets. All these plants produce much of waste in additions to greeny and nuts. This waste of spade is used for the production of various molecules that are used in industry and pharma sector. Fermentation techniques are used to generate economically important enzymes for industrial and pharmaceutical purposes. Cellulase enzyme degrades the cellulose in between β-1, 4 glucosidic link found in lignocellulosic complex which under physical treatment is slower to degrade. The present study of Aspergillus niger for cellulose production was carried in solid state (SS) and submerged (SM) fermentations for production of cellulase enzyme. Cellulase production in SSF after 72 h of fermentation was 8.02 and in SMF activity was 2.98 per ml of cultured broth at H 6 and temperature at 30°C. Both SMF and SSF were supplemented with lactose and lactobionic acid, which acted as cellulase P production inducers. The aim of the present work was to study the effect of Areca palm spade as substrate for Aspergillus niger and its cellulase production under SMF and SSF.

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Development of Areca Nut Climbing And Harvesting Machine With Pesticide

IOP Conference Series Materials Science and Engineering ◽

10.1088/1757-899x/1059/1/012074 ◽

2021 ◽

Vol 1059 (1) ◽

pp. 012074

Author(s):

C Sathishkumar ◽

G Dineshkumar ◽

K S Karthikeyan ◽

P Prasanna

Keyword(s):

Areca Nut

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Role of Phase II Enzymes in the Bioactivation of 1,4-Dichlorobenzene and 1,4-Dibromobenzene

Alternatives to Laboratory Animals ◽

10.1177/026119299602400422 ◽

1996 ◽

Vol 24 (4) ◽

pp. 603-608

Author(s):

Moreno Paolini ◽

Laura Pozzetti ◽

Renata Mesirca ◽

Andrea Sapone ◽

Paola Silingardi ◽

...

Keyword(s):

Dna Binding ◽

Phase I ◽

Phase Ii ◽

Covalent Binding ◽

Fold Increase ◽

Test System ◽

Oxidative Enzymes ◽

Transferase Activity ◽

Genetic Toxicology

The use of sodium phenobarbital (PB, CYP2B1 inducer) combined with β-naphthoflavone (β-NF, 1A1) to induce certain Phase I reactions in S9 liver fractions is a standard method for conducting short-term bioassays for genotoxicity. However, because post-oxidative enzymes are also able to activate many precarcinogens, we tested the possibility of adapting S9 liver fractions derived from Phase II-induced rodents to the field of genetic toxicology. In this study, S9 liver fractions derived from Swiss albino CD1 mice fed 7.5g/kg 2-(3)-tert-butyl-4-hydroxyanisole (BHA; a monofunctional Phase II-inducer) for 3 weeks, show a clear pattern of induction with an approximately 3.5–9.5-fold increase in glutathione S-transferase activity. In vitro DNA binding of the promutagenic agents, [14C]-l,4-dichlorobenzene (DCB) and [14C]-1,4-dibromobenzene (DBB), is mediated by such metabolic liver preparations and showed a significant increase in covalent binding capability. In some instances, enzyme activity was more elevated when compared to that obtained with traditional (Phase I-induced) S9. Together with DNA binding, the genetic response of these chemicals in the diploid D7 strain of Saccharomyces cerevisiae used as a biological test system, revealed the ability of the BHA-derived preparations to activate the promutagenic agents, as exemplified by the significant enhancement of mitotic gene-conversion (up to 5.2-fold for DCB and 3.4-fold for DBB) and reverse point mutation (up to 3.6-fold for DCB and 2.5-fold for DBB) at a 4mM concentration. This novel metabolising biosystem, with enhanced Phase II activity, is recommended together with a traditional S9, for detecting unknown promutagens in genotoxicity studies. The routine use of either oxidative or post-oxidative S9 increases the responsiveness of the test and can contribute to the identification of promutagens not detected when using traditional protocols.

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