The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

AbstractThe current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects.

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Metal/Metal Oxide Nanoparticles: Toxicity, Applications, and Future Prospects

Current Pharmaceutical Design ◽

10.2174/1381612825666191111091326 ◽

2019 ◽

Vol 25 (37) ◽

pp. 4013-4029 ◽

Cited By ~ 12

Author(s):

Ratiram G. Chaudhary ◽

Ganesh S. Bhusari ◽

Ashish D. Tiple ◽

Alok R. Rai ◽

Subhash R. Somkuvar ◽

...

Keyword(s):

Metal Oxide ◽

Metal Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Therapeutic Effects ◽

Future Prospects ◽

Testing Methods ◽

Metal Metal ◽

Microbial Infections ◽

Crop Disease ◽

The Impact

The ever-growing resistance of pathogens to antibiotics and crop disease due to pest has triggered severe health concerns in recent years. Consequently, there is a need of powerful and protective materials for the eradication of diseases. Metal/metal oxide nanoparticles (M/MO NPs) are powerful agents due to their therapeutic effects in microbial infections. In this context, the present review article discusses the toxicity, fate, effects and applications of M/MO NPs. This review starts with an introduction, followed by toxicity aspects, antibacterial and testing methods and mechanism. In addition, discussion on the impact of different M/MO NPs and their characteristics such as size, shape, particle dissolution on their induced toxicity on food and plants, as well as applications in pesticides. Finally, prospective on current and future issues are presented.

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Current Scenario in Green Approaches for Metal/Metal Oxide Nanoparticles Synthesis

Green Metal Nanoparticles ◽

10.1002/9781119418900.ch14 ◽

2018 ◽

pp. 467-512

Author(s):

Selvaraj Mohana Roopan

Keyword(s):

Metal Oxide ◽

Metal Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Metal Metal ◽

Nanoparticles Synthesis ◽

Current Scenario

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Fabrication of polymeric 3D structure containing metal/metal oxide nanoparticles by two-photon processes

10.1117/12.505406 ◽

2003 ◽

Author(s):

Xuan-Ming Duan ◽

Hong-Bo Sun ◽

Koshiro Kaneko ◽

Satoshi Kawata

Keyword(s):

Metal Oxide ◽

Metal Oxide Nanoparticles ◽

3D Structure ◽

Oxide Nanoparticles ◽

Two Photon ◽

Metal Metal

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Flower-Based Green Synthesis of Metallic Nanoparticles: Applications beyond Fragrance

Nanomaterials ◽

10.3390/nano10040766 ◽

2020 ◽

Vol 10 (4) ◽

pp. 766 ◽

Cited By ~ 6

Author(s):

Harsh Kumar ◽

Kanchan Bhardwaj ◽

Kamil Kuča ◽

Anu Kalia ◽

Eugenie Nepovimova ◽

...

Keyword(s):

Silver Nanoparticles ◽

Metal Oxide ◽

Green Synthesis ◽

Metallic Nanoparticles ◽

Metal Oxide Nanoparticles ◽

Secondary Compounds ◽

Oxide Nanoparticles ◽

Gold And Silver Nanoparticles ◽

Gold Silver ◽

Metal Metal

Green synthesis has gained wide attention as a sustainable, reliable, and eco-friendly approach to the synthesis of a variety of nanomaterials, including hybrid materials, metal/metal oxide nanoparticles, and bioinspired materials. Plant flowers contain diverse secondary compounds, including pigments, volatile substances contributing to fragrance, and other phenolics that have a profound ethnobotanical relevance, particularly in relation to the curing of diseases by ‘Pushpa Ayurveda’ or floral therapy. These compounds can be utilized as potent reducing agents for the synthesis of a variety of metal/metal oxide nanoparticles (NPs), such as gold, silver, copper, zinc, iron, and cadmium. Phytochemicals from flowers can act both as reducing and stabilizing agents, besides having a role as precursor molecules for the formation of NPs. Furthermore, the synthesis is mostly performed at ambient room temperatures and is eco-friendly, as no toxic derivatives are formed. The NPs obtained exhibit unique and diverse properties, which can be harnessed for a variety of applications in different fields. This review reports the use of a variety of flower extracts for the green synthesis of several types of metallic nanoparticles and their applications. This review shows that flower extract was mainly used to design gold and silver nanoparticles, while other metals and metal oxides were less explored in relation to this synthesis. Flower-derived silver nanoparticles show good antibacterial, antioxidant, and insecticidal activities and can be used in different applications.

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