Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats

2003 ◽  
Vol 167 (1) ◽  
pp. 103-111 ◽  
Author(s):  
S. P. Vickers ◽  
L. J. Webster ◽  
A. Wyatt ◽  
C. T. Dourish ◽  
G. A. Kennett
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Receptor Antagonist ◽  
Body Weight Gain ◽  
Zucker Rats ◽  
Cannabinoid Cb1 Receptor ◽  
Sr 141716 ◽  
Cb1 Receptor Antagonist ◽  
Cannabinoid Cb1 Receptor Antagonist

987 des-acyl Ghrelin Suppresses Food Intake and Body Weight Gain in Adult Obese Zucker Rats

2008 ◽  
Vol 134 (4) ◽  
pp. A-148 ◽  
Author(s):  
Andreas Stengel ◽  
Anna-Sophia Wisser ◽  
Peter Kobelt ◽  
Miriam Goebel ◽  
Bertram Wiedenmann ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Body Weight Gain ◽  
Zucker Rats ◽  
Obese Zucker Rats ◽  
Acyl Ghrelin

LY226936 Administered Orally and Centrally to Obese Zucker Rats Suppresses Food Intake and Body Weight Gain

1994 ◽  
Vol 2 (5) ◽  
pp. 458-468
Author(s):  
Walter N. Shaw ◽  
James A. Clemens ◽  
Jill A. Parietta
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Body Weight Gain ◽  
Zucker Rats ◽  
Obese Zucker Rats

scholarly journals The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat

2011 ◽  
Vol 97 (3) ◽  
pp. 537-543 ◽  
Author(s):  
Nina L. Cluny ◽  
Adam P. Chambers ◽  
V. Kiran Vemuri ◽  
JodiAnne T. Wood ◽  
Lindsay K. Eller ◽  
...  
Keyword(s):  
Body Weight ◽  
Receptor Antagonist ◽  
Energy Intake ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Cb1 Receptor Antagonist ◽  
Cannabinoid Cb1 Receptor Antagonist

Food intake inhibition and reduction in body weight gain in rats treated with GI264879A, a non-selective NPY-Y1 receptor antagonist

Peptides ◽  
2001 ◽  
Vol 22 (3) ◽  
pp. 483-491 ◽  
Author(s):  
A.J Danielsa ◽  
W.T Chance ◽  
M.K Grizzle ◽  
D Heyer ◽  
J.E Matthews
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Receptor Antagonist ◽  
Body Weight Gain ◽  
Y1 Receptor

Influence of Thyroid Status on Body Weight Gain, Food Intake and Serum Lipid Levels in Genetically Obese Zucker Rats

1987 ◽  
Vol 117 (1) ◽  
pp. 159-163 ◽  
Author(s):  
Annie Loireau ◽  
Paul Dumas ◽  
Nicole Autissier ◽  
Raymond Michel
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Serum Lipid ◽  
Body Weight Gain ◽  
Zucker Rats ◽  
Lipid Levels ◽  
Thyroid Status ◽  
Serum Lipid Levels ◽  
Obese Zucker Rats

Subdiaphragmatic vagal deafferentation affects body weight gain and glucose metabolism in obese male Zucker (fa/fa) rats

2005 ◽  
Vol 289 (4) ◽  
pp. R1027-R1034 ◽  
Author(s):  
Bettina Ferrari ◽  
Myrtha Arnold ◽  
Richard D. Carr ◽  
Wolfgang Langhans ◽  
Giovanni Pacini ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
Food Intake ◽  
Plasma Glucose ◽  
Body Weight Gain ◽  
Zucker Rats ◽  
Sensitivity Index ◽  
Insulin Sensitivity Index ◽  
Obese Rats

We investigated the effect of subdiaphragmatic vagal deafferentation (SDA) on food intake, body weight gain, and metabolism in obese ( fa/ fa) and lean ( Fa/?) Zucker rats. Before and after recovery from surgery, food intake and body weight gain were recorded, and plasma glucose and insulin were measured in tail-prick blood samples. After implantation of a jugular vein catheter, an intravenous glucose tolerance test (IVGTT) was performed, followed by minimal modeling to estimate the insulin sensitivity index. Food intake relative to metabolic body weight (g/kg0.75) and daily body weight gain after surgery were lower ( P < 0.05) in SDA than in sham obese but not lean rats. Before surgery, plasma glucose and insulin concentrations were lower ( P < 0.05) in lean than in obese rats but did not differ between surgical groups within both genotypes. Four weeks after surgery, plasma glucose and insulin were still similar in SDA and sham lean rats but lower ( P < 0.05) in SDA than in sham obese rats. IVGTT revealed a downward shift of the plasma insulin profile by SDA in obese but not lean rats, whereas the plasma glucose profile was unaffected. SDA decreased ( P < 0.05) area under the curve for insulin but not glucose in obese rats. The insulin sensitivity index was higher in lean than in obese rats but was not affected by SDA in both genotypes. These results suggest that elimination of vagal afferent signals from the upper gut reduces food intake and body weight gain without affecting the insulin sensitivity index measured by minimal modeling in obese Zucker rats.

Suppressing effect of the cannabinoid CB1 receptor antagonist, SR 141716, on alcohol's motivational properties in alcohol-preferring rats

2004 ◽  
Vol 498 (1-3) ◽  
pp. 119-123 ◽  
Author(s):  
Giancarlo Colombo ◽  
Giovanni Vacca ◽  
Salvatore Serra ◽  
Mauro A.M. Carai ◽  
Gian Luigi Gessa
Keyword(s):  
Receptor Antagonist ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Sr 141716 ◽  
Cb1 Receptor Antagonist ◽  
Cannabinoid Cb1 Receptor Antagonist

Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist

2004 ◽  
Vol 177 (1-2) ◽  
pp. 35-45 ◽  
Author(s):  
Torbj�rn U. C. J�rbe ◽  
Michele Y. Harris ◽  
Chen Li ◽  
Qian Liu ◽  
Alexandros Makriyannis
Keyword(s):  
Receptor Antagonist ◽  
Discriminative Stimulus ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Sr 141716 ◽  
Discriminative Stimulus Effects ◽  
Stimulus Effects ◽  
Cb1 Receptor Antagonist ◽  
Cannabinoid Cb1 Receptor Antagonist
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