Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht6 receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task

2008 ◽  
Vol 202 (1-3) ◽  
pp. 111-123 ◽  
Author(s):  
M. V. King ◽  
C. H. Spicer ◽  
A. J. Sleight ◽  
C. A. Marsden ◽  
K. C. F. Fone
Keyword(s):  
Receptor Antagonist ◽  
Discrimination Task ◽  
The Novel ◽  
Object Discrimination ◽  
Novel Object

scholarly journals Visual Object Discrimination Impairment as an Early Predictor of Mild Cognitive Impairment and Alzheimer’s Disease

2019 ◽  
Vol 25 (7) ◽  
pp. 688-698 ◽  
Author(s):  
Leslie S. Gaynor ◽  
Rosie E. Curiel Cid ◽  
Ailyn Penate ◽  
Mónica Rosselli ◽  
Sara N. Burke ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Discrimination Task ◽  
Inverse Function ◽  
Visual Object ◽  
Object Discrimination ◽  
Cognitively Normal ◽  
Novel Object

AbstractObjective:Detection of cognitive impairment suggestive of risk for Alzheimer’s disease (AD) progression is crucial to the prevention of incipient dementia. This study was performed to determine if performance on a novel object discrimination task improved identification of earlier deficits in older adults at risk for AD.Method:In total, 135 participants from the 1Florida Alzheimer’s Disease Research Center [cognitively normal (CN), Pre-mild cognitive impairment (PreMCI), amnestic mild cognitive impairment (aMCI), and dementia] completed a test of object discrimination and traditional memory measures in the context of a larger neuropsychological and clinical evaluation.Results:The Object Recognition and Discrimination Task (ORDT) revealed significant differences between the PreMCI, aMCI, and dementia groups versus CN individuals. Moreover, relative risk of being classified as PreMCI rather than CN increased as an inverse function of ORDT score.Discussion:Overall, the obtained results suggest that a novel object discrimination task improves the detection of very early AD-related cognitive impairment, increasing the window for therapeutic intervention. (JINS, 2019,25, 688–698)

scholarly journals Evaluating the Reaction to a Complex Rotated Object in the American Quarter Horse (Equus caballus)

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1383
Author(s):  
Megan Elizabeth Corgan ◽  
Temple Grandin ◽  
Sarah Matlock
Keyword(s):  
Behavioral Responses ◽  
Equus Caballus ◽  
T Test ◽  
Complex Object ◽  
The Novel ◽  
Novel Object ◽  
Quarter Horse ◽  
First Pass ◽  
Young Horses ◽  
Familiar Objects

It is dangerous for both riders and horses when a horse suddenly startles. Sometimes horses do this in familiar environments because familiar objects may look different when rotated. The purpose of this study was to determine whether horses that had been habituated to a complex object (children’s playset) would react to the object as novel when rotated 90 degrees. Twenty young horses were led past the playset 15 times by a handler. Next, the rotated group was led past the rotated playset 15 times. Each time the horse was led by the object was a pass. The behavioral responses observed and analyzed were ears focused on the object, nostril flares, neck raising, snort, avoid by stopping, avoid by moving feet sideways, and avoid by flight. An increasing reactivity scale was used to quantify behavioral responses. A two-sample t-test was performed on the reactivity scores comparing the first pass by the novel object to the first pass by the rotated object. The horses in the rotated group reacted to the rotated orientation similarly to the first exposure (p = 0.001, α < 0.05). Being aware of potential reactions to changes in previously familiar environments can help keep the handler safer.

P1-235: Effects of the novel histamine H3 receptor antagonist S 38093 in a non-human primate model of cognitive dysfunction

2009 ◽  
Vol 5 (4S_Part_8) ◽  
pp. P245-P245
Author(s):  
Jay S. Schneider ◽  
Emmanuel Decamp ◽  
Michael Hill ◽  
Erwan Bezard ◽  
Alan Crossman ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Cognitive Dysfunction ◽  
The Novel ◽  
Primate Model ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Human Primate ◽  
Histamine H3
Sign in / Sign up

Export Citation Format

Share Document