scholarly journals Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers

2011 ◽  
Vol 215 (4) ◽  
pp. 643-653 ◽  
Author(s):  
Lynette M. James ◽  
Robert Iannone ◽  
John Palcza ◽  
John J. Renger ◽  
Nicole Calder ◽  
...  
1995 ◽  
Vol 268 (5) ◽  
pp. R1310-R1318 ◽  
Author(s):  
M. Lancel ◽  
J. Cronlein ◽  
P. Muller-Preuss ◽  
F. Holsboer

Activation of the immune system by microorganisms or specific microbial constituents promotes non-rapid-eye-movement (REM) sleep (non-REMS). In this study, we assessed the effects of lipopolysaccharide (LPS) on sleep duration, electroencephalogram (EEG) power spectra, and brain temperature (Tbr) in rats. Twenty-four hour recordings were made before and after intraperitoneal injection of vehicle or 30 or 100 micrograms/kg LPS at lights on. During the first 12 h after administration of both doses of LPS, Tbr was elevated, REMS duration was reduced, and non-REMS duration was unchanged, whereas the non-REMS episodes were shortened. EEG activity within non-REMS from 0.5 to 7 Hz was enhanced during hours 3-12. During the second 12-h period, the number of non-REMS and REMS episodes and the total time in both states were increased. EEG activity within non-REMS was mainly reduced in the entire frequency range (0.5-25.5 Hz). The effects of LPS did not differ between the doses. The effects of LPS on EEG power spectra are similar to those observed after sleep deprivation, i.e., a physiological intensification of non-REMS, indicating that both manipulations may activate common sleep EEG regulatory mechanisms. However, the disruption of non-REMS continuity following LPS administration at light onset contrasts the changes induced by sleep deprivation and may reflect an effect of a systemic inflammatory response on sleep maintenance.


1984 ◽  
Vol 14 (3) ◽  
pp. 171-182 ◽  
Author(s):  
Alexander A. Borbély ◽  
Irene Tobler ◽  
Mehmet Hanagasioglu

2010 ◽  
Vol 88 (6) ◽  
pp. 831-839 ◽  
Author(s):  
R Iannone ◽  
J Palcza ◽  
J J Renger ◽  
N Calder ◽  
K Cerchio ◽  
...  

2000 ◽  
Vol 9 (2) ◽  
pp. 175-183 ◽  
Author(s):  
Hans-Peter Landolt ◽  
Luca A. Finelli ◽  
Corinne Roth ◽  
Alfred Buck ◽  
Peter Achermann ◽  
...  

1991 ◽  
Vol 548 (1-2) ◽  
pp. 206-214 ◽  
Author(s):  
Marike Lancel ◽  
Henk van Riezen ◽  
Alfred Glatt

1991 ◽  
Vol 261 (1) ◽  
pp. R198-R208 ◽  
Author(s):  
P. Franken ◽  
D. J. Dijk ◽  
I. Tobler ◽  
A. A. Borbely

Vigilance states, electroencephalogram (EEG) power spectra (0.25-25.0 Hz), and cortical temperature (TCRT) of 10 rats were obtained during a baseline day, a 24-h sleep deprivation (SD) period, and 2 days of recovery (recoveries 1 and 2). EEG power density in waking gradually increased in most frequencies during the SD period. Non-rapid-eye-movement (NREM) sleep was enhanced on both recovery days, and rapid-eye-movement sleep was enhanced only on recovery 1. In the initial 4 h of recovery 1, EEG slow-wave activity (SWA; mean power density 0.75-4.0 Hz) in NREM sleep was elevated relative to baseline, and the number of brief awakenings (nBA) was reduced. In the dark period of recovery 1 and the light period of recovery 2, SWA was below baseline, and nBA was increased. During the entire recovery period, SWA and nBA, both expressed as deviation from baseline values, were negatively correlated. During the SD period, TCRT was above baseline, and in the initial 16 h of recovery 1 it was below baseline. Whereas TCRT was negatively correlated with NREM sleep, no significant correlation was found between TCRT and SWA within NREM sleep. It is concluded that SD causes a short-lasting intensification of sleep, as indicated by the enhanced SWA and the reduced nBA, and a long-lasting increase in sleep duration. The different time courses of SWA and TCRT suggest that variations in NREM sleep intensity are not directly related to changes in TCRT.


2014 ◽  
Vol 9 (4) ◽  
pp. 703-716 ◽  
Author(s):  
Claudio Imperatori ◽  
Mariantonietta Fabbricatore ◽  
Marco Innamorati ◽  
Benedetto Farina ◽  
Maria Isabella Quintiliani ◽  
...  

1995 ◽  
Vol 196 (1-2) ◽  
pp. 49-52 ◽  
Author(s):  
Milka Ćulić ◽  
Jasna Šaponjić ◽  
Bogdan Janković ◽  
Slobodan Udović ◽  
Slaviša Popović ◽  
...  

1988 ◽  
Vol 7 (1) ◽  
pp. 131-132 ◽  
Author(s):  
D. Bartko ◽  
P. Turcani ◽  
J. Danisova ◽  
S. Janco ◽  
P. Traubner ◽  
...  

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