Lipopolysaccharide increases EEG delta activity within non-REM sleep and disrupts sleep continuity in rats

1995 ◽  
Vol 268 (5) ◽  
pp. R1310-R1318 ◽  
Author(s):  
M. Lancel ◽  
J. Cronlein ◽  
P. Muller-Preuss ◽  
F. Holsboer
Keyword(s):  
Sleep Deprivation ◽  
Rem Sleep ◽  
Brain Temperature ◽  
Power Spectra ◽  
Eeg Activity ◽  
Eeg Power Spectra ◽  
Sleep Maintenance ◽  
Before And After ◽  
Delta Activity ◽  
Eeg Power

Activation of the immune system by microorganisms or specific microbial constituents promotes non-rapid-eye-movement (REM) sleep (non-REMS). In this study, we assessed the effects of lipopolysaccharide (LPS) on sleep duration, electroencephalogram (EEG) power spectra, and brain temperature (Tbr) in rats. Twenty-four hour recordings were made before and after intraperitoneal injection of vehicle or 30 or 100 micrograms/kg LPS at lights on. During the first 12 h after administration of both doses of LPS, Tbr was elevated, REMS duration was reduced, and non-REMS duration was unchanged, whereas the non-REMS episodes were shortened. EEG activity within non-REMS from 0.5 to 7 Hz was enhanced during hours 3-12. During the second 12-h period, the number of non-REMS and REMS episodes and the total time in both states were increased. EEG activity within non-REMS was mainly reduced in the entire frequency range (0.5-25.5 Hz). The effects of LPS did not differ between the doses. The effects of LPS on EEG power spectra are similar to those observed after sleep deprivation, i.e., a physiological intensification of non-REMS, indicating that both manipulations may activate common sleep EEG regulatory mechanisms. However, the disruption of non-REMS continuity following LPS administration at light onset contrasts the changes induced by sleep deprivation and may reflect an effect of a systemic inflammatory response on sleep maintenance.

Effect of sleep deprivation on sleep and EEG power spectra in the rat

1984 ◽  
Vol 14 (3) ◽  
pp. 171-182 ◽  
Author(s):  
Alexander A. Borbély ◽  
Irene Tobler ◽  
Mehmet Hanagasioglu
Keyword(s):  
Sleep Deprivation ◽  
Power Spectra ◽  
Eeg Power Spectra ◽  
Eeg Power

Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep

2009 ◽  
Vol 24 (11) ◽  
pp. 1613-1618 ◽  
Author(s):  
DJ Dijk ◽  
LM James ◽  
S Peters ◽  
JK Walsh ◽  
S Deacon
Keyword(s):  
Sex Differences ◽  
Rem Sleep ◽  
Power Spectra ◽  
Eeg Power Spectra ◽  
Eeg Power

scholarly journals Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers

2011 ◽  
Vol 215 (4) ◽  
pp. 643-653 ◽  
Author(s):  
Lynette M. James ◽  
Robert Iannone ◽  
John Palcza ◽  
John J. Renger ◽  
Nicole Calder ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Power Spectra ◽  
Inverse Agonist ◽  
Eeg Power Spectra ◽  
Recovery Sleep ◽  
Male Volunteers ◽  
Eeg Power ◽  
Subtype 3 ◽  
Receptor Inverse Agonist

Opioid self-administration and rem sleep EEG power spectra

1980 ◽  
Vol 19 (1) ◽  
pp. 69-74 ◽  
Author(s):  
G.F. Steinfels ◽  
G.A. Young ◽  
N. Khazan
Keyword(s):  
Rem Sleep ◽  
Power Spectra ◽  
Sleep Eeg ◽  
Self Administration ◽  
Eeg Power Spectra ◽  
Eeg Power

scholarly journals Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia

2012 ◽  
Vol 37 (5) ◽  
pp. 1224-1233 ◽  
Author(s):  
Paolo Bettica ◽  
Lisa Squassante ◽  
John A Groeger ◽  
Brian Gennery ◽  
Raphaelle Winsky-Sommerer ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Rem Sleep ◽  
Power Spectra ◽  
Differential Effects ◽  
Eeg Power Spectra ◽  
Eeg Power

scholarly journals EEG Power Spectra Changes and Forebrain Ischemia in Rats

2003 ◽  
Vol 30 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Giuseppina Mariucci ◽  
Maria Antonietta Stasi ◽  
Roberto Taurelli ◽  
Paolo Nardò ◽  
Michela Tantucci ◽  
...  
Keyword(s):  
Neuronal Damage ◽  
Power Spectra ◽  
Brain Regions ◽  
Bioelectrical Activity ◽  
Spectra Analysis ◽  
Neuronal Necrosis ◽  
Eeg Power Spectra ◽  
Delta Activity ◽  
Eeg Power ◽  
Wistar Kyoto

Background:Several animal models of cerebral ischemia have been developed to investigate both pathophysiology and pharmacological treatment. The aim of this study was to verify the prognostic value of EEG power spectra analysis in a two-vessel plus hypotension rat model of transient global ischemia.Methods:Spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) were subjected to 20 min bilateral common carotid artery occlusion plus hypotension by sodium nitroprusside followed by reperfusion for seven days. Sham-operated animals served as controls. The changes after ischemia in EEG power spectra, and their relations with neuronal damage and astrocytic response were investigated.Results:The EEG analysis revealed that in SHRs and WKYs, ischemia produced a dramatic increase in delta activity and a decrease in theta, beta and alpha activities derived from both cortical and hippocampal areas. EEG activity reverted to normal values more quickly in WKYs than in SHRs which did not recover cortical and hippocampal alpha and beta activities even at six days of reperfusion. SHRs presented more severe damage and intense astrocytosis than WKYs in almost all the brain regions analyzed. In SHRs, hippocampal delta activity was positively correlated with the degree of neuronal necrosis and astrocytic activation, whereas theta, alpha and beta activities correlated negatively. No correlations were found in WKYs.Conclusions:These data indicate that the hippocampal bioelectrical activity recorded in SHRs from the beginning of reperfusion could be useful for predicting the ischemic outcome and evaluating the effects of pharmacological interventions.

DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range

1995 ◽  
Vol 268 (1) ◽  
pp. E107-E113 ◽  
Author(s):  
E. Friess ◽  
L. Trachsel ◽  
J. Guldner ◽  
T. Schier ◽  
A. Steiger ◽  
...  
Keyword(s):  
Eye Movement ◽  
Rem Sleep ◽  
Hormone Secretion ◽  
Power Spectra ◽  
Memory Storage ◽  
Sleep Stages ◽  
Rapid Eye Movement ◽  
Frequency Range ◽  
Eeg Power Spectra ◽  
Eeg Power

Dehydroepi-androsterone (DHEA) exhibits various behavioral effects in mammals, at least one of which is enhancement of memory that appears to be mediated by an interaction with the gamma-aminobutyric acidA (GABAA) receptor complex. We investigated the effects of a single oral dose of DHEA (500 mg) on sleep stages, sleep stage-specific electroencephalogram (EEG) power spectra, and concurrent hormone secretion in 10 healthy young men. DHEA administration induced a significant (P < 0.05) increase in rapid eye movement (REM) sleep, whereas all other sleep variables remained unchanged compared with the placebo condition. Spectral analysis of five selected EEG bands revealed significantly (P < 0.05) enhanced EEG activity in the sigma frequency range during REM sleep in the first 2-h sleep period after DHEA administration. In contrast, the EEG power spectra of non-REM sleep were not affected, nor were the nocturnal time course curves of plasma cortisol, growth hormone, or testosterone concentration. The results suggest that DHEA administration has a mixed GABAA-agonistic/antagonistic effect, exerted either directly or through DHEA-induced changes in steroid metabolism. Because REM sleep has been implicated in memory storage, its augmentation in the present study suggests the potential clinical usefulness of DHEA in age-related dementia.

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