scholarly journals Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity

2016 ◽  
Vol 408 (5) ◽  
pp. 1425-1443 ◽  
Author(s):  
Jelle Reinen ◽  
Geert Postma ◽  
Cornelis Tump ◽  
Tom Bloemberg ◽  
Jasper Engel ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Metabolic Activity ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3 ◽  
Cocktail Approach

Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space

2011 ◽  
Vol 39 (9) ◽  
pp. 1568-1576 ◽  
Author(s):  
Jelle Reinen ◽  
Jolanda S. van Leeuwen ◽  
Yongmin Li ◽  
Lifang Sun ◽  
Peter D. J. Grootenhuis ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Metabolic Activity ◽  
Chemical Space ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3 ◽  
Efficient Screening

The Role of Protein Plasticity in Computational Rationalization Studies on Regioselectivity in Testosterone Hydroxylation by Cytochrome P450 BM3 Mutants

2012 ◽  
Vol 13 (2) ◽  
pp. 155-166 ◽  
Author(s):  
Stephanie B.A. de Beer ◽  
Laura A.H. van Bergen ◽  
Karlijn Keijzer ◽  
Vanina Rea ◽  
Harini Venkataraman ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3 ◽  
Testosterone Hydroxylation

scholarly journals Engineering the biomimetic cofactors of NMNH for cytochrome P450 BM3 based on binding conformation refinement

RSC Advances ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 12036-12042
Author(s):  
Yao Liu ◽  
Yalong Cong ◽  
Chuanxi Zhang ◽  
Bohuan Fang ◽  
Yue Pan ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Rational Design ◽  
Design Strategy ◽  
Efficient Utilization ◽  
P450 Bm3 ◽  
Binding Conformation ◽  
Cytochrome P450 Bm3

A rational design strategy was proposed to improve the efficient utilization of alternative biomimetic cofactor by P450 BM3 enzyme.

scholarly journals Reduction of Dioxygen Catalyzed by Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes

2004 ◽  
Vol 126 (33) ◽  
pp. 10218-10219 ◽  
Author(s):  
Andrew K. Udit ◽  
Michael G. Hill ◽  
V. Garrett Bittner ◽  
Frances H. Arnold ◽  
Harry B. Gray
Keyword(s):  
Cytochrome P450 ◽  
P450 Bm3 ◽  
Heme Domain ◽  
Cytochrome P450 Bm3

Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone

Xenobiotica ◽  
2010 ◽  
Vol 41 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Jelle Reinen ◽  
Livia L. Kalma ◽  
Selina Begheijn ◽  
Ferry Heus ◽  
Jan N.M. Commandeur ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cytochrome P450 ◽  
Receptor Binding ◽  
P450 Bm3 ◽  
Estrogen Receptor Binding ◽  
Cytochrome P450 Bm3

scholarly journals Formation of Transient Oxygen Complexes of Cytochrome P450 BM3 and Nitric Oxide Synthase under High Pressure

2003 ◽  
Vol 85 (5) ◽  
pp. 3303-3309 ◽  
Author(s):  
Stéphane Marchal ◽  
Hazel Mary Girvan ◽  
Antonius C.F. Gorren ◽  
Bernd Mayer ◽  
Andrew William Munro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
High Pressure ◽  
Cytochrome P450 ◽  
Nitric Oxide Synthase ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3 ◽  
Oxide Synthase ◽  
Oxygen Complexes

Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants

2015 ◽  
Vol 232 (1) ◽  
pp. 182-192 ◽  
Author(s):  
Galvin Vredenburg ◽  
Shalenie den Braver-Sewradj ◽  
Barbara M.A. van Vugt-Lussenburg ◽  
Nico P.E. Vermeulen ◽  
Jan N.M. Commandeur ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Anticancer Drugs ◽  
P450 Bm3 ◽  
Cytochrome P450 Bm3
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