Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics

2021 ◽  
Author(s):  
Chenxi Wang ◽  
Xu Pang ◽  
Tongtong Zhu ◽  
Shuhua Ma ◽  
Yunfei Liang ◽  
...  
Keyword(s):  
Panax Notoginseng ◽  
Untargeted Metabolomics ◽  
Data Independent Acquisition ◽  
Using Data

scholarly journals Longitudinal stability of urinary extracellular vesicle protein patterns within and between individuals

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leyla A. Erozenci ◽  
Sander R. Piersma ◽  
Thang V. Pham ◽  
Irene V. Bijnsdorp ◽  
Connie R. Jimenez
Keyword(s):  
Expression Patterns ◽  
Interaction Network ◽  
Extracellular Vesicle ◽  
Protein Signaling ◽  
Protein Patterns ◽  
Specific Expression ◽  
Non Invasive ◽  
Data Independent Acquisition ◽  
Time Period ◽  
Using Data

AbstractThe protein content of urinary extracellular vesicles (EVs) is considered to be an attractive non-invasive biomarker source. However, little is known about the consistency and variability of urinary EV proteins within and between individuals over a longer time-period. Here, we evaluated the stability of the urinary EV proteomes of 8 healthy individuals at 9 timepoints over 6 months using data-independent-acquisition mass spectrometry. The 1802 identified proteins had a high correlation amongst all samples, with 40% of the proteome detected in every sample and 90% detected in more than 1 individual at all timepoints. Unsupervised analysis of top 10% most variable proteins yielded person-specific profiles. The core EV-protein-interaction network of 516 proteins detected in all measured samples revealed sub-clusters involved in the biological processes of G-protein signaling, cytoskeletal transport, cellular energy metabolism and immunity. Furthermore, gender-specific expression patterns were detected in the urinary EV proteome. Our findings indicate that the urinary EV proteome is stable in longitudinal samples of healthy subjects over a prolonged time-period, further underscoring its potential for reliable non-invasive diagnostic/prognostic biomarkers.

scholarly journals Proteomic comparison of osteoarthritic and reference human menisci using data-independent acquisition mass spectrometry

2020 ◽  
Vol 28 (8) ◽  
pp. 1092-1101
Author(s):  
E. Folkesson ◽  
A. Turkiewicz ◽  
N. Ali ◽  
M. Rydén ◽  
H.V. Hughes ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Data Independent Acquisition ◽  
Using Data

scholarly journals Proteomic characterization of the normal human medial meniscus body using data‐independent acquisition mass spectrometry

2020 ◽  
Vol 38 (8) ◽  
pp. 1735-1745 ◽  
Author(s):  
Elin Folkesson ◽  
Aleksandra Turkiewicz ◽  
Martin Rydén ◽  
Harini Velocity Hughes ◽  
Neserin Ali ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Medial Meniscus ◽  
Data Independent Acquisition ◽  
Normal Human ◽  
Using Data

scholarly journals Proteome Analysis of Human Neutrophil Granulocytes From Patients With Monogenic Disease Using Data-independent Acquisition

2019 ◽  
Vol 18 (4) ◽  
pp. 760-772 ◽  
Author(s):  
Piotr Grabowski ◽  
Sebastian Hesse ◽  
Sebastian Hollizeck ◽  
Meino Rohlfs ◽  
Uta Behrends ◽  
...  
Keyword(s):  
Human Neutrophil ◽  
Proteome Analysis ◽  
Monogenic Disease ◽  
Neutrophil Granulocytes ◽  
Data Independent Acquisition ◽  
Using Data

scholarly journals Data on protein changes of chick vitreous during normal eye growth using data-independent acquisition (SWATH-MS)

Data in Brief ◽  
2020 ◽  
Vol 30 ◽  
pp. 105576 ◽  
Author(s):  
Jimmy Ka-Wai Cheung ◽  
King-Kit Li ◽  
Lei Zhou ◽  
Chi-Ho To ◽  
Thomas Chuen Lam
Keyword(s):  
Eye Growth ◽  
Data Independent Acquisition ◽  
Using Data
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