scholarly journals Enhancement of task-switching performance with transcranial direct current stimulation over the right lateral prefrontal cortex

2021 ◽  
Author(s):  
Kristin Prehn ◽  
Anja Skoglund ◽  
Tilo Strobach
Keyword(s):  
Prefrontal Cortex ◽  
Task Switching ◽  
Direct Current ◽  
Executive Control ◽  
Transcranial Direct Current Stimulation ◽  
Lateral Prefrontal Cortex ◽  
Direct Current Stimulation ◽  
Switching Performance ◽  
The Right ◽  
And Task

AbstractSwitching between two or more tasks is a key component in our modern world. Task switching, however, requires time-consuming executive control processes and thus produces performance costs when compared to task repetitions. While executive control during task switching has been associated with activation in the lateral prefrontal cortex (lPFC), only few studies so far have investigated the causal relation between lPFC activation and task-switching performance by modulating lPFC activation. In these studies, the results of lPFC modulation were not conclusive or limited to the left lPFC. In the present study, we aimed to investigate the effect of non-invasive transcranial direct current stimulation [tDCS; anodal tDCS (1 mA, 20 min) vs. cathodal tDCS (1 mA, 20 min) vs. sham tDCS (1 mA, 30 s)] over the right inferior frontal junction on task-switching performance in a well-established task-switching paradigm. In response times, we found a significant effect of tDCS Condition (atDCS, ctDCS vs. sham) on task-switching costs, indicating the modulation of task-switching performance by tDCS. In addition, we found a task-unspecific tDCS Condition effect in the first experimental session, in which participants were least familiar with the task, indicating a general enhancement of task performance in both task repetitions and task-switching trials. Taken together, our study provides evidence that the right lPFC is involved in task switching as well as in general task processing. Further studies are needed to investigate whether these findings can be translated into clinically relevant improvement in older subjects or populations with executive function impairment.

scholarly journals Transcranial Direct Current Stimulation (tDCS) over the Left Dorsal Lateral Prefrontal Cortex in Children with Autism Spectrum Disorder (ASD)

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Jiujun Qiu ◽  
Xuejun Kong ◽  
Jihan Li ◽  
Jie Yang ◽  
Yiting Huang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Sleep Habits ◽  
Lateral Prefrontal Cortex ◽  
Direct Current Stimulation ◽  
Children With Asd

Recently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and the Repetitive Behavior Scale-Revised (RBS-R). We found that children with ASD can tolerate three-week tDCS treatment with no serious adverse events detected. A within-group comparison showed that real tDCS, but not sham tDCS, can significantly reduce the scores of CARS, Children’s Sleep Habits Questionnaire (CSHQ), and general impressions in CARS (15th item). Real tDCS produced significant score reduction in the CSHQ and in CARS general impressions when compared to the effects of sham tDCS. The pilot study suggests that three-week left DLPFC tDCS is well-tolerated and may hold potential in relieving some symptoms in children with ASD.

scholarly journals Verbal Fluency in Mild Alzheimer’s Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex

2021 ◽  
pp. 1-11
Author(s):  
Daniela Smirni ◽  
Massimiliano Oliveri ◽  
Eliana Misuraca ◽  
Angela Catania ◽  
Laura Vernuccio ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Verbal Fluency ◽  
Dorsolateral Prefrontal Cortex ◽  
Control Group ◽  
Direct Current Stimulation ◽  
Cathodal Tdcs ◽  
Dorsolateral Prefrontal ◽  
The Right

Background: Recent studies showed that in healthy controls and in aphasic patients, inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) over the right prefrontal cortex can improve phonemic fluency performance, while anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex can improve performance in naming and semantic fluency tasks. Objective: This study aimed at investigating the effects of cathodal tDCS over the left or the right dorsolateral prefrontal cortex (DLPFC) on verbal fluency tasks (VFT) in patients with mild Alzheimer’s disease (AD). Methods: Forty mild AD patients participated in the study (mean age 73.17±5.61 years). All participants underwent cognitive baseline tasks and a VFT twice. Twenty patients randomly received cathodal tDCS to the left or the right DLPFC, and twenty patients were assigned to a control group in which only the two measures of VFT were taken, without the administration of the tDCS. Results: A significant improvement of performance on the VFT in AD patients was present after tDCS over the right DLPFC (p = 0.001). Instead, no difference was detected between the two VFTs sessions after tDCS over the left DLPFC (p = 0.42). Furthermore, these results cannot be related to task learning effects, since no significant difference was found between the two VFT sessions in the control group (p = 0.73). Conclusion: These data suggest that tDCS over DLPFC can improve VFT performance in AD patients. A hypothesis is that tDCS enhances adaptive patterns of brain activity between functionally connected areas.

Modulation of Executive Control in the Task Switching Paradigm With Transcranial Direct Current Stimulation (tDCS)

2016 ◽  
Vol 30 (2) ◽  
pp. 55-65 ◽  
Author(s):  
Tilo Strobach ◽  
Daria Antonenko ◽  
Tamara Schindler ◽  
Agnes Flöel ◽  
Torsten Schubert
Keyword(s):  
Task Switching ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Neural Activation ◽  
Direct Current Stimulation ◽  
Performance Effects ◽  
Within Subjects ◽  
Mixing Costs ◽  
Task Experience ◽  
And Task

Abstract. Executive processing in the task switching paradigm is primarily associated with activation of the lateral prefrontal cortex (lPFC), demonstrated in numerous functional imaging studies (e.g., Brass & von Cramon, 2002 ). However, there are only very few attempts to modulate neural activation related with executive functions and to investigate the effects of this modulation on the performance in this paradigm. To modulate lPFC activity here, we used the non-invasive transcranial Direct Current Stimulation (tDCS; atDCS [1 mA, 20 min] vs. ctDCS [1 mA, 20 min] vs. sham stimulation [1 mA, 30 s]) over the left inferior frontal junction under conditions of single tasks, task repetitions, and task switches in the task switching paradigm. We assessed the performance effects of online tDCS on mixing costs (single tasks vs. task repetitions) as well as on switching costs (task repetitions vs. task switches). In a within-subjects design across three sessions, there was no evidence of stimulation on the magnitude of these cost types. However, when taking a between-subjects perspective in the first session (i.e., after excluding dominant effects of task experience), atDCS showed an increase in mixing costs in contrast to ctDCS and sham. We interpreted this finding in the context of task switching theories on task activation and task inhibition and their neural localizations.

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