Opioid inhibition of rat medial vestibular nucleus neurones in vitro and its dependence on age

1998 ◽  
Vol 122 (2) ◽  
pp. 196-202 ◽  
Author(s):  
M. Roslan Sulaiman ◽  
M. B. Dutia
Keyword(s):  
Vestibular Nucleus ◽  
Medial Vestibular Nucleus

Membrane and firing properties of avian medial vestibular nucleus neurons in vitro

1995 ◽  
Vol 176 (5) ◽  
pp. 641-651 ◽  
Author(s):  
S. du Lac ◽  
S. G. Lisberger
Keyword(s):  
Vestibular Nucleus ◽  
Medial Vestibular Nucleus ◽  
Firing Properties

An in vitro investigation of the effects of the analogue, Org 2766, on guinea pig medial vestibular nucleus neurons

Peptides ◽  
1996 ◽  
Vol 17 (4) ◽  
pp. 681-688 ◽  
Author(s):  
Darrin P.D. Gilchrist ◽  
Cynthia L. Darlington ◽  
Paul F. Smith
Keyword(s):  
Guinea Pig ◽  
Vestibular Nucleus ◽  
Medial Vestibular Nucleus ◽  
In Vitro Investigation ◽  
Org 2766

Histamine depolarizes rat medial vestibular nucleus neurons recorded intracellularly in vitro

1990 ◽  
Vol 109 (3) ◽  
pp. 287-292 ◽  
Author(s):  
Kevin D. Phelan ◽  
Jun Nakamura ◽  
Joel P. Gallagher
Keyword(s):  
Vestibular Nucleus ◽  
Medial Vestibular Nucleus

Tanshinone IIA Suppresses Hypoxia-induced Apoptosis in Medial Vestibular Nucleus Cells Via a Skp2/BKCa Axis

2020 ◽  
Vol 26 (33) ◽  
pp. 4185-4194
Author(s):  
Jing-Jing Zhu ◽  
Shu-Hui Wu ◽  
Xiang Chen ◽  
Ting-Ting Jiang ◽  
Xin-Qian Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Cell Apoptosis ◽  
Cell Damage ◽  
Vestibular Nucleus ◽  
Tanshinone Iia ◽  
Medial Vestibular Nucleus ◽  
Protective Effects ◽  
Induced Apoptosis

Background: The aim of the present study was to investigate the protective effects of Tanshinone IIA (Tan IIA) on hypoxia-induced injury in the medial vestibular nucleus (MVN) cells. Methods: An in vitro hypoxia model was established using MVN cells exposed to hypoxia. The hypoxia-induced cell damage was confirmed by assessing cell viability, apoptosis and expression of apoptosis-associated proteins. Oxidative stress and related indicators were also measured following hypoxia modeling and Tan IIA treatment, and the genes potentially involved in the response were predicted using multiple GEO datasets. Results: The results of the present study showed that Tan IIA significantly increased cell viability, decreased cell apoptosis and decreased the ratio of Bax/Bcl-2 in hypoxia treated cells. In addition, hypoxia treatment increased oxidative stress in MVN cells, and treatment with Tan IIA reduced the oxidative stress. The expression of SPhase Kinase Associated Protein 2 (SKP2) was upregulated in hypoxia treated cells, and Tan IIA treatment reduced the expression of SKP2. Mechanistically, SKP2 interacted with large-conductance Ca2+-activated K+ channels (BKCa), regulating its expression, and BKCa knockdown alleviated the protective effects of Tan IIA on hypoxia induced cell apoptosis. Conclusion: The results of the present study suggested that Tan IIA had a protective effect on hypoxia-induced cell damage through its anti-apoptotic and anti-oxidative activity via an SKP2/BKCa axis. These findings suggest that Tan IIA may be a potential therapeutic for the treatment of hypoxia-induced vertigo.

Metabotropic glutamate receptors in the guinea-pig medial vestibular nucleus in vitro

Neuroreport ◽  
1995 ◽  
Vol 6 (13) ◽  
pp. 1799-1802 ◽  
Author(s):  
Cynthia L. Darlington ◽  
Paul F. Smith
Keyword(s):  
Guinea Pig ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Vestibular Nucleus ◽  
Medial Vestibular Nucleus ◽  
Metabotropic Glutamate

Nitric oxide increases the spontaneous firing rate of rat medial vestibular nucleus neurons in vitro via a cyclic GMP-mediated PKG-independent mechanism

2004 ◽  
Vol 20 (8) ◽  
pp. 2124-2132 ◽  
Author(s):  
Maria Vittoria Podda ◽  
Maria Elena Marcocci ◽  
Leonardo Oggiano ◽  
Marcello D'Ascenzo ◽  
Eusebio Tolu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Firing Rate ◽  
Cyclic Gmp ◽  
Vestibular Nucleus ◽  
Medial Vestibular Nucleus ◽  
Spontaneous Firing ◽  
Independent Mechanism ◽  
Spontaneous Firing Rate

Effects of toluene on tonic firing and membrane properties of rat medial vestibular nucleus neurones in vitro

1998 ◽  
Vol 779 (1-2) ◽  
pp. 334-337 ◽  
Author(s):  
Anna K Magnusson ◽  
M.Roslan Sulaiman ◽  
Mayank B Dutia ◽  
Richard Tham
Keyword(s):  
Vestibular Nucleus ◽  
Membrane Properties ◽  
Medial Vestibular Nucleus ◽  
Tonic Firing

Tonic activity of rat medial vestibular nucleus neurones in vitro and its inhibition by GABA

1992 ◽  
Vol 88 (3) ◽  
Author(s):  
M.B. Dutia ◽  
A.R. Johnston ◽  
D.S. McQueen
Keyword(s):  
Vestibular Nucleus ◽  
Medial Vestibular Nucleus ◽  
Tonic Activity

Electrophysiological evidence for cholinoceptive neurons in the medial vestibular nucleus: Studies on rat brain stem in vitro

1988 ◽  
Vol 93 (2-3) ◽  
pp. 231-235 ◽  
Author(s):  
Hisamitsu Ujihara ◽  
Akinori Akaike ◽  
Masashi Sasa ◽  
Shuji Takaori
Keyword(s):  
Brain Stem ◽  
Rat Brain ◽  
Vestibular Nucleus ◽  
Medial Vestibular Nucleus ◽  
Electrophysiological Evidence
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