Pediatric Reference Values for Tibial Trabecular Bone Mineral Density and Bone Geometry Parameters Using Peripheral Quantitative Computed Tomography

Objective.To investigate the effect of rheumatoid arthritis (RA) on volumetric bone mineral density (vBMD) and bone geometry in postmenopausal women treated with bisphosphonates.Methods.Fifty-three postmenopausal women with RA and 87 control subjects, comparable in terms of age, body mass index, and years since menopause, underwent peripheral quantitative computed tomography (pQCT) of the nondominant tibia.Results.At 4% (trabecular site), trabecular bone mineral content (BMC) and vBMD (p < 0.001) were lower in the RA group, while trabecular area was comparable. At 38% (cortical site), cortical BMC (p < 0.01), area (p < 0.05), and thickness (p < 0.001) were lower in the RA group, whereas vBMD was comparable. Endosteal circumference was higher (p < 0.05), whereas periosteal circumference was comparable, indicating cancellization of cortical bone. In the RA group, muscle area was lower (p < 0.001), while at 14% polar stress strength index was significantly lower (p < 0.01) in patients with RA, indicating impairment of bone mechanical properties.Conclusion.RA is associated with negative effects on both cortical and cancellous bone in postmenopausal women treated with bisphosphonates. Cortical geometric properties are also adversely affected mainly by increased endosteal circumference, whereas trabecular geometric properties are generally preserved.

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Measurement of Trabecular Bone Mineral Density in the Thoracic Spine Using Cardiac Gated Quantitative Computed Tomography

Journal of Computer Assisted Tomography ◽

10.1097/00004728-200401000-00023 ◽

2004 ◽

Vol 28 (1) ◽

pp. 134-139 ◽

Cited By ~ 45

Author(s):

Leon Lenchik ◽

Rong Shi ◽

Thomas C Register ◽

Stephanie R Beck ◽

Carl D Langefeld ◽

...

Keyword(s):

Computed Tomography ◽

Bone Mineral Density ◽

Trabecular Bone ◽

Bone Mineral ◽

Thoracic Spine ◽

Quantitative Computed Tomography ◽

Mineral Density ◽

Trabecular Bone Mineral Density

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Three-Dimensional Characterization of Trabecular Bone Mineral Density of the Distal Radius Utilizing Quantitative Computed Tomography

Hand ◽

10.1177/1558944718789407 ◽

2018 ◽

Vol 15 (1) ◽

pp. 131-139 ◽

Cited By ~ 1

Author(s):

Tyler S. Pidgeon ◽

Katia A. DaSilva ◽

Joseph J. Crisco ◽

Eric C. Johnson ◽

Alison B. Chambers ◽

...

Keyword(s):

Computed Tomography ◽

Bone Mineral Density ◽

Trabecular Bone ◽

Distal Radius ◽

Bone Mineral ◽

Quantitative Computed Tomography ◽

Three Dimensional ◽

Mineral Density ◽

Quantitative Ct ◽

Trabecular Bone Mineral Density

Background: Distal radius (DR) fractures demonstrate patterns of predictable fragments. Bone mineral density (BMD) measurements of these regions of interest (ROIs) may guide more precise treatment. Methods: Computed tomography (CT) scans of the DR of 42 healthy volunteers (23 female) were analyzed using quantitative CT software, measuring BMD within trabecular bone. Seven ROIs were described by alignment with the distal (volar ulnar distal [VUD], dorsal ulnar distal [DUD], volar radial distal [VRD], and dorsal radial distal [DRD]) or proximal (middle ulnar proximal [MUP], middle proximal [MP], and middle radial proximal [MRP]) sigmoid notch. Additional ROIs were the radial styloid (RS) and metadiaphysis (MD). A general estimation equation assessed subject’s BMDs with predictive factors of gender, ROI, and age. The interaction between gender, ROI, and age was included in the model to allow for differences in ROI to vary with gender and/or age. Results: Comparing ROIs within the same gender and, separately, within the same age group revealed significantly higher BMD adjacent to the radioulnar and radiocarpal joints. Male and female individuals aged ≥50 years (mean: 172.7 mg/cm3 ± 6.1) had significantly lower BMD than those aged <50 years (mean: 202.7 mg/cm3 ± 5.8) when all ROIs were considered. Males had higher mean BMD at each ROI compared with females; these differences were significant in 5 of the 9 ROIs: VUD, DUD, DRD, RS, MUP. Conclusions: Trabecular BMD of the DR is highest adjacent to the radioulnar and radiocarpal joints. Female patients and those ≥50 years have lower trabecular BMD.

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