scholarly journals Relationship Between Changes in Serum Levels of Intact Parathyroid Hormone and Sclerostin After a Single Dose of Zoledronic Acid: Results of a Phase 1 Pharmacokinetic Study

2021 ◽  
Author(s):  
Tatsuhiko Kuroda ◽  
Masataka Shiraki ◽  
Toshitaka Nakamura ◽  
Hiroaki Suzuki ◽  
Kazuki Hiraishi ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Zoledronic Acid ◽  
Pharmacokinetic Study ◽  
Phase 1 ◽  
Early Time ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Study Data ◽  
Intact Parathyroid Hormone ◽  
Time Points

AbstractAlthough changes in serum sclerostin levels at 12 months after infusion of zoledronic acid have been reported, the changes in sclerostin levels at earlier time points are poorly understood. We reanalyzed the study data of a previous phase 1 pharmacokinetic study and investigated the correlation between changes in sclerostin levels and relevant factors in calcium metabolism. A total of 24 Japanese female subjects with primary postmenopausal osteoporosis were administered a single 4- or 5-mg dose of zoledronic acid. Serum and urine samples were collected on days 15, 29, 90, 180, and 365 after administration. Serum levels of calcium, phosphate, intact parathyroid hormone (iPTH), and sclerostin were measured. Levels of serum sclerostin were unchanged from baseline on days 15 and 29, but increased significantly on day 90, subsequently decreased significantly on day 180, and returned to baseline levels on day 365. A significant negative correlation was observed between changes in iPTH levels at early time points and sclerostin levels at later time points. This suggests that sclerostin was negatively regulated by iPTH, and the decrease in sclerostin may indicate the start of bone formation during later time points after zoledronic acid injection.

Serum β-glucuronidase activity as a biomarker for acute cholinesterase inhibitor pesticide poisoning

2018 ◽  
Vol 34 (12) ◽  
pp. 891-897 ◽  
Author(s):  
Doha M Beltagy ◽  
Kadry M Sadek ◽  
Amal S Hafez
Keyword(s):  
Serum Levels ◽  
Significant Negative Correlation ◽  
Repeated Measurements ◽  
Control Group ◽  
Pesticide Poisoning ◽  
Time Points ◽  
Diagnosis And Prognosis ◽  
Glucuronidase Activity ◽  
Reliable Marker ◽  
Group Serum

β-glucuronidase (BG) activity is a promising biomarker for diagnosis and prognosis after exposure to organophosphorous (OP) pesticides. The aim of this study was to evaluate the changes in serum BG activity in patients with acute OP poisoning and to determine whether these changes correlate with the severity of poisoning. Thirty patients with anticholinesterase pesticide poisoning were included, besides 10 healthy volunteers as a control group. Serum activities of butyrylcholinesterase (BuChE) and BG were measured for each subject on admission, then after 12 and 24 h. Serum levels of BuChE and BG in poisoned patients were significantly different from the control subjects; these differences persisted in repeated measurements. Moreover, the serum levels showed significant differences within each group of the three time points. A significant negative correlation was found between the serum activities of BuChE and BG in all groups at the three time points. In conclusion, serum BG activity seems a reliable marker for OP poisoning even when measured at 24 h after poisoning.

Serum levels of intact parathyroid hormone in elderly patients with hip fracture living at home

1992 ◽  
Vol 126 (1) ◽  
pp. 10-12 ◽  
Author(s):  
Jan A Falch ◽  
Morten Mowé ◽  
Thomas Bøhmer ◽  
Egil Haug
Keyword(s):  
Risk Factor ◽  
Parathyroid Hormone ◽  
Hip Fracture ◽  
Elderly Patients ◽  
Secondary Hyperparathyroidism ◽  
Serum Levels ◽  
Intact Parathyroid Hormone ◽  
Control Subjects ◽  
Home Living ◽  
Age And Sex

The serum levels of intact parathyroid hormone and cholecalciferol metabolites have been measured in patients with hip fracture above 70 years of age admitted to hospital from home-living conditions and compared with serum levels in age- and sex-matched home-living control subjects. It was found that patients with hip fracture had significantly lower levels of calcidiol (29.7±15.9 vs 46.0±27.8 nmol/l) and calcitriol (63.6±25.0 vs 91.1±39.5 pmol/l) with no difference in serum levels of intact parathyroid hormone (47.2±2.1 vs 5.3±3.3 pmol/l). The data suggest that secondary hyperparathyroidism is not an important risk factor in our population of patients with hip fracture.

Further evidence for the selective disruption of intercellular communication by heptanol

1999 ◽  
Vol 276 (6) ◽  
pp. H1911-H1917 ◽  
Author(s):  
G. J. Christ ◽  
M. Spektor ◽  
P. R. Brink ◽  
L. Barr
Keyword(s):  
Steady State ◽  
Intercellular Communication ◽  
Linear Regression Analysis ◽  
Early Time ◽  
Aortic Ring ◽  
Significant Negative Correlation ◽  
Time Interval ◽  
Time Points ◽  
Pharmacomechanical Coupling ◽  
Gap Junctional

The lack of selective gap junctional uncoupling agents has hampered evaluation of the contribution of intercellular communication to pharmacomechanical coupling and vascular contractility. Thus we further explored the utility and selectivity of heptanol as a gap junctional uncoupling agent in isolated rat aortic rings. Fifty-two aortic rings were obtained from 15 rats and were precontracted to ∼75% of maximum with phenylephrine (PE). When contraction achieved steady state (∼5 min), a single concentration of heptanol (200 μM) was added to each aortic ring at 1- to 3-min intervals for up to 42 min post-PE addition. At early time points (5–10 min after PE), heptanol elicited an ∼50% loss of tension (i.e., relaxation). At subsequent time points post-PE, a gradual and time-dependent decrease in the magnitude of the heptanol-induced relaxation was observed until, after ∼40 min, addition of heptanol was associated with little, if any, detectable relaxation. Linear regression analysis of the magnitude of the heptanol-induced relaxation vs. the square root of the elapsed time interval (from addition of PE) revealed a highly significant negative correlation ( P < 0.001, R = 0.81). Studies conducted on KCl-precontracted aortic rings revealed no detectable heptanol-induced relaxation after development of the steady-state KCl-induced contraction. These data extend our previous observations to further document the potential utility of heptanol as a “relatively selective” uncoupling agent.

Serum levels of intact parathyroid hormone on the first day after total thyroidectomy as predictor of permanent hypoparathyroidism

2019 ◽  
Vol 66 (3) ◽  
pp. 195-201
Author(s):  
Pablo Calvo Espino ◽  
José Ángel Rivera Bautista ◽  
Mariano Artés Caselles ◽  
Javier Serrano González ◽  
Arturo García Pavía ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Total Thyroidectomy ◽  
Serum Levels ◽  
Intact Parathyroid Hormone ◽  
Permanent Hypoparathyroidism
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