Valproic acid—induced hyperammonemic encephalopathy in a full-term neonate: a brief review and case report

2017 ◽  
Vol 73 (5) ◽  
pp. 647-649 ◽  
Author(s):  
Pavla Pokorná ◽  
Karolina Hronová ◽  
Martin Šíma ◽  
Ondřej Slanař ◽  
Petr Klement ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Case Report ◽  
Full Term ◽  
Term Neonate ◽  
Hyperammonemic Encephalopathy

Extreme short bowel syndrome in a full-term neonate—a case report

2003 ◽  
Vol 38 (11) ◽  
pp. 1665-1666 ◽  
Author(s):  
Jeroen Heemskerk ◽  
George H Sie ◽  
Anita M Van den Neucker ◽  
Pierre-Philippe Forget ◽  
Erik Heineman ◽  
...  
Keyword(s):  
Case Report ◽  
Short Bowel Syndrome ◽  
Full Term ◽  
Term Neonate ◽  
Short Bowel

scholarly journals Valproic acid induced hyperammonemic encephalopathy: A case report (Turkish)

2018 ◽  
Vol 21 (1) ◽  
pp. 102-106
Author(s):  
Ferda Apa ◽  
Figen Çulha Ateşci ◽  
Gülfizar Sözeri Varma
Keyword(s):  
Valproic Acid ◽  
Case Report ◽  
Hyperammonemic Encephalopathy

scholarly journals Two Siblings With Valproate-Related Hyperammonemia and Novel Mutations in Glutamine Synthetase (GLUL) Treated With Carglumic Acid

2020 ◽  
Vol 7 ◽  
pp. 2329048X2096788 ◽  
Author(s):  
Jennifer Bennett ◽  
Christy Gilkes ◽  
Karin Klassen ◽  
Marina Kerr ◽  
Aneal Khan
Keyword(s):  
Valproic Acid ◽  
Case Report ◽  
Glutamine Synthetase ◽  
Negative Correlation ◽  
Seizure Control ◽  
Novel Mutations ◽  
Strong Negative Correlation ◽  
Acid Therapy ◽  
Plasma Ammonia ◽  
Hyperammonemic Encephalopathy

This case report describes 2 siblings with myoclonic epilepsy who had novel mutations in the glutamine synthetase ( GLUL) gene: c.316C>T, p.(Arg106*) and c.42G>C, p.(Lys14Asn). Valproic acid improved seizure control, but was associated with hyperammonemic encephalopathy. Addition of carglumic acid reduced ammonia levels but drug coverage was declined. We therefore designed a protocol to measure the reduction in plasma ammonia in response to carglumic acid therapy. After the first dose of carglumic acid, Patient 1 showed a reduction in plasma ammonia levels within 3 hours, from 114 umol/L to 68 umol/L (reference 12-47 umol/L), and Patient 2 from 108 umol/L to 80 umol/L, which was sustained over a 2 week period. Overall, there was a strong negative correlation between plasma ammonia levels and carglumic acid levels (r = −0.86, p = 0.0013), and recurrence of hyperammonemic encephalopathy was not observed while the patients were taking carglumic acid.

scholarly journals VALPROIC ACID TOXICITY INDUCED BY LACOSAMIDE: A RARE CASE REPORT

2017 ◽  
Vol 10 (9) ◽  
pp. 1 ◽  
Author(s):  
Karthika Ashok Kumar ◽  
Chanshi Chandran ◽  
Remya Reghu
Keyword(s):  
Valproic Acid ◽  
Case Report ◽  
Rare Case ◽  
Hyperammonemic Encephalopathy ◽  
Rare Case Report ◽  
Acid Toxicity

Valproic acid is commonly used in the treatment of both focal and generalized epilepsies and is often tolerated well.Valproic acid is usually tolerated well, but serious complications, including hepatotoxicity and hyperammonemic encephalopathy, may occur. Here we report a case of valproic acid induced hyperammonemic encephalopathy on concomitant use with lacosamide. 

scholarly journals Stenotrophomonas maltophilia Meningitis in a Term Healthy Neonate: A Case Report and Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Judy Ibrahim ◽  
Nadia Hamwi ◽  
Hala Rabei ◽  
Mohamed Abdelghafar ◽  
Zahraa Al-Dulaimi ◽  
...  
Keyword(s):  
Case Report ◽  
Multidrug Resistance ◽  
Literature Review ◽  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Full Term ◽  
Term Neonate ◽  
Pathogenic Potential ◽  
Environmental Bacterium ◽  
Healthy Neonate

Stenotrophomonas maltophilia is an environmental bacterium of growing concern due to its multidrug resistance and pathogenic potential. It is considered an opportunistic pathogen of nosocomial origin most of the time, targeting a specific patients' population. We describe a case of a previously healthy full-term neonate who was found to have S. maltophilia meningitis and was successfully treated with a combination of Trimethoprim-Sulfamethoxazole and Ciprofloxacin.

scholarly journals Use of Color Doppler Ultrasound for the Diagnosis of Subarachnoid Hemorrhage in Asymptomatic Full-Term Neonate: A Case Report

2012 ◽  
Vol 03 (02) ◽  
pp. 151-153
Author(s):  
Hélio A. Guimarães Filho ◽  
Janett J. Liberalino ◽  
Ana T. P. Mendonça ◽  
Carlos V. S. B. Leite Filho ◽  
Leonardo F. Felipe ◽  
...  
Keyword(s):  
Case Report ◽  
Subarachnoid Hemorrhage ◽  
Doppler Ultrasound ◽  
Color Doppler ◽  
Color Doppler Ultrasound ◽  
Full Term ◽  
Term Neonate

Impact of haemolysis on vancomycin disposition in a full-term neonate treated with extracorporeal membrane oxygenation

Perfusion ◽  
2020 ◽  
pp. 026765912097359
Author(s):  
Pavla Pokorná ◽  
Martin Šíma ◽  
Dick Tibboel ◽  
Ondřej Slanař
Keyword(s):  
Acute Kidney Injury ◽  
Case Report ◽  
Extracorporeal Membrane Oxygenation ◽  
Kidney Injury ◽  
Pharmacokinetic Profile ◽  
Full Term ◽  
Term Neonate ◽  
Population Pharmacokinetic ◽  
Membrane Oxygenation ◽  
Elimination Half

Introduction: Extracorporeal membrane oxygenation (ECMO) is a lifesaving support technology for potentially reversible neonatal cardiac and/or respiratory failure. Pharmacological consequences of ECMO-induced haemolysis in neonates are not well understood. Case report: We report a case report of a full-term neonate treated for congenital diaphragmatic hernia and sepsis with ECMO and with vancomycin. While the population elimination half-life of 7 h was estimated, fitting of the simulated population pharmacokinetic profile to truly observed drug concentration points resulted in the personalized value of 41 h. Discussion: The neonate developed ECMO-induced haemolysis with subsequent acute kidney injury resulting in prolonged drug elimination. Whole blood/serum ratio of 0.79 excluded possibility of direct increase of vancomycin serum concentration during haemolysis. Conclusion: Vancomycin elimination may be severely prolonged due to ECMO-induced haemolysis and acute kidney injury, while hypothesis of direct increase of vancomycin levels by releasing the drug from blood cells during haemolysis has been disproved.

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