Ca2+-Permeable Acid-sensing Ion Channels and Ischemic Brain Injury

2006 ◽  
Vol 209 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Z.-G. Xiong ◽  
X.-P. Chu ◽  
R.P. Simon
Keyword(s):  
Brain Injury ◽  
Ion Channels ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Acid Sensing Ion Channels

Calcium-permeable Ion Channels and Ischemic Brain Injury

2012 ◽  
pp. 9-17
Author(s):  
Bentham Science Publisher Bentham Science Publisher
Keyword(s):  
Brain Injury ◽  
Ion Channels ◽  
Ischemic Brain Injury ◽  
Ischemic Brain

scholarly journals Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Deborah R. Morris ◽  
Cathy W. Levenson
Keyword(s):  
Brain Injury ◽  
Ion Channels ◽  
Kainate Receptors ◽  
Zinc Toxicity ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
The Central Nervous System ◽  
Excitatory Neurotransmission ◽  
The Brain

Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc. This paper discusses the role of the excitotoxic influx and accumulation of zinc, the mechanisms responsible for its cytotoxicity, and a number of disorders of the central nervous system that have been linked to these neuronal ion channels and zinc toxicity including ischemic brain injury, traumatic brain injury, and epilepsy.

scholarly journals Acid-Sensing Ion Channels and Mechanosensation

2021 ◽  
Vol 22 (9) ◽  
pp. 4810
Author(s):  
Nina Ruan ◽  
Jacob Tribble ◽  
Andrew M. Peterson ◽  
Qian Jiang ◽  
John Q. Wang ◽  
...  
Keyword(s):  
Ion Channels ◽  
Underlying Mechanism ◽  
Cation Channels ◽  
Ischemic Brain Injury ◽  
Mechanical Forces ◽  
Sodium Permeability ◽  
Ischemic Brain ◽  
Acid Sensing Ion Channels ◽  
The Central Nervous System ◽  
Spring Mechanism

Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial sodium channel superfamily due to their sodium permeability. Predominantly expressed in the central nervous system, ASICs are involved in synaptic plasticity, learning/memory, and fear conditioning. These channels have also been implicated in multiple disease conditions, including ischemic brain injury, multiple sclerosis, Alzheimer’s disease, and drug addiction. Recent research has illustrated the involvement of ASICs in mechanosensation. Mechanosensation is a form of signal transduction in which mechanical forces are converted into neuronal signals. Specific mechanosensitive functions have been elucidated in functional ASIC1a, ASIC1b, ASIC2a, and ASIC3. The implications of mechanosensation in ASICs indicate their subsequent involvement in functions such as maintaining blood pressure, modulating the gastrointestinal function, and bladder micturition, and contributing to nociception. The underlying mechanism of ASIC mechanosensation is the tether-gate model, which uses a gating-spring mechanism to activate ASIC responses. Further understanding of the mechanism of ASICs will help in treatments for ASIC-related pathologies. Along with the well-known chemosensitive functions of ASICs, emerging evidence has revealed that mechanosensitive functions of ASICs are important for maintaining homeostasis and contribute to various disease conditions.

scholarly journals Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury

2011 ◽  
Vol 32 (6) ◽  
pp. 734-740 ◽  
Author(s):  
Ming-hua Li ◽  
Koichi Inoue ◽  
Hong-fang Si ◽  
Zhi-gang Xiong
Keyword(s):  
Brain Injury ◽  
Ion Channels ◽  
Glutamate Receptor ◽  
Ischemic Brain Injury ◽  
Ischemic Brain

Roles of the C-terminal peptide binding domain of human inducible HSP70 in focal ischemic brain injury

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S53-S53
Author(s):  
Yunjuan Sun ◽  
Yibing Ouyang ◽  
Lijun Xu ◽  
Rona G Giffard
Keyword(s):  
Brain Injury ◽  
Peptide Binding ◽  
Binding Domain ◽  
Ischemic Brain Injury ◽  
Ischemic Brain
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