Calcium-Permeable Ion Channels and Ischemic Brain Injury

2008 ◽  
pp. 9-17
Author(s):  
Theresa A. Lusardi
Keyword(s):  
Brain Injury ◽  
Ion Channels ◽  
Ischemic Brain Injury ◽  
Ischemic Brain

Calcium-permeable Ion Channels and Ischemic Brain Injury

2012 ◽  
pp. 9-17
Author(s):  
Bentham Science Publisher Bentham Science Publisher
Keyword(s):  
Brain Injury ◽  
Ion Channels ◽  
Ischemic Brain Injury ◽  
Ischemic Brain

scholarly journals Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Deborah R. Morris ◽  
Cathy W. Levenson
Keyword(s):  
Brain Injury ◽  
Ion Channels ◽  
Kainate Receptors ◽  
Zinc Toxicity ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
The Central Nervous System ◽  
Excitatory Neurotransmission ◽  
The Brain

Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc. This paper discusses the role of the excitotoxic influx and accumulation of zinc, the mechanisms responsible for its cytotoxicity, and a number of disorders of the central nervous system that have been linked to these neuronal ion channels and zinc toxicity including ischemic brain injury, traumatic brain injury, and epilepsy.

scholarly journals Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury

2011 ◽  
Vol 32 (6) ◽  
pp. 734-740 ◽  
Author(s):  
Ming-hua Li ◽  
Koichi Inoue ◽  
Hong-fang Si ◽  
Zhi-gang Xiong
Keyword(s):  
Brain Injury ◽  
Ion Channels ◽  
Glutamate Receptor ◽  
Ischemic Brain Injury ◽  
Ischemic Brain
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