Vitamin D receptor gene (VDR) polymorphisms and the urolithiasis risk: an updated meta-analysis based on 20 case–control studies

Abstract Background: The association between the polymorphisms in the vitamin D receptor (VDR) gene and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to May 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. To find the potential sources of heterogeneity, meta-regression and subgroup analysis were also performed. Results: A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in Africans and Americans, respectively. Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

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Association of Vitamin D Receptor Gene Polymorphisms with Asthma Risk: Systematic Review and Updated Meta-analysis of Case–Control Studies

Lung ◽

10.1007/s00408-014-9648-8 ◽

2014 ◽

Vol 192 (6) ◽

pp. 955-965 ◽

Cited By ~ 34

Author(s):

Kalthoum Tizaoui ◽

Anissa Berraies ◽

Besma Hamdi ◽

Wajih Kaabachi ◽

Kamel Hamzaoui ◽

...

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Receptor Gene ◽

Case Control ◽

Vitamin D Receptor Gene ◽

Case Control Studies ◽

Asthma Risk ◽

Receptor Gene Polymorphisms

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Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Affect Birth Weight and the Risk of Preterm Birth: Results From the “Mamma & Bambino” Cohort and A Meta-Analysis

Nutrients ◽

10.3390/nu10091172 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1172 ◽

Cited By ~ 17

Author(s):

Martina Barchitta ◽

Andrea Maugeri ◽

Maria La Rosa ◽

Roberta Magnano San Lio ◽

Giuliana Favara ◽

...

Keyword(s):

Vitamin D ◽

Birth Weight ◽

Preterm Birth ◽

Vitamin D Receptor ◽

Meta Analysis ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Anthropometric Measures ◽

Adverse Pregnancy ◽

Vdr Polymorphisms

The effect of vitamin D receptor gene (VDR) polymorphisms on adverse pregnancy outcomes—including preterm birth (PTB), low birth weight and small for gestational age—is currently under debate. We investigated 187 mother-child pairs from the Italian “Mamma & Bambino” cohort to evaluate the association of maternal VDR polymorphisms—BsmI, ApaI, FokI and TaqI—with neonatal anthropometric measures and the risk of PTB. To corroborate our results, we conducted a meta-analysis of observational studies. For the FokI polymorphism, we showed that gestational duration and birth weight decreased with increasing number of A allele (p = 0.040 and p = 0.010, respectively). Compared to the GG and GA genotypes, mothers who carried the AA genotype exhibited higher PTB risk (OR = 12.049; 95% CI = 2.606–55.709; p = 0.001) after adjusting for covariates. The meta-analysis confirmed this association under the recessive model (OR = 3.67, 95%CI 1.18–11.43), and also pointed out the protective effect of BsmI polymorphism against the risk of PTB under the allelic (A vs. G: OR = 0.74; 95%CI 0.59–0.93) and recessive (AA vs. GG + AG: OR = 0.62; 95%CI 0.43–0.89) models. Our results suggest the association between some maternal VDR polymorphisms with neonatal anthropometric measures and the risk of PTB.

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