Expert opinion: what are the greatest challenges and barriers to applying evidence-based and practical approaches to preclinical and clinical research in the field of pediatric radiology?

2014 ◽  
Vol 44 (10) ◽  
pp. 1209-1212 ◽  
Author(s):  
Amaka C. Offiah ◽  
Savvas Andronikou ◽  
Fred Avni ◽  
Pedro Daltro ◽  
Lane F. Donnelly ◽  
...  
Keyword(s):  
Clinical Research ◽  
Expert Opinion ◽  
Pediatric Radiology ◽  
Evidence Based

scholarly journals Cancer clinical research in Latin America: current situation and opportunities. Expert opinion from the first ESMO workshop on clinical trials, Lima, 2015: Table 1

ESMO Open ◽  
2016 ◽  
Vol 1 (4) ◽  
pp. e000055 ◽  
Author(s):  
Christian Rolfo ◽  
Christian Caglevic ◽  
Denisse Bretel ◽  
David Hong ◽  
Luis E Raez ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Latin America ◽  
Clinical Research ◽  
Expert Opinion ◽  
Current Situation

scholarly journals Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update

Medicina ◽  
2021 ◽  
Vol 57 (1) ◽  
pp. 58
Author(s):  
Arrigo F. G. Cicero ◽  
Federica Fogacci ◽  
Masanari Kuwabara ◽  
Claudio Borghi
Keyword(s):  
Clinical Trials ◽  
Uric Acid ◽  
Clinical Research ◽  
Safety Profile ◽  
Therapeutic Strategies ◽  
Evidence Based ◽  
Acute Management ◽  
Efficacy And Safety ◽  
Uricosuric Agents ◽  
Xanthine Oxidase Inhibitors

This article aims to critically review the evidence on the available therapeutic strategies for the treatment of hyperuricemia. For this reason, several papers were reviewed. Xanthine oxidase inhibitors are the safest and most effective uric acid lowering drugs for the management of chronic hyperuricemia, while the efficacy of uricosuric agents is strongly modulated by pharmacogenetics. Emergent drugs (lesinurad, peglotidase) were found to be more effective for the acute management of refractory hyperuricemia, but their use is supported by a relatively small number of clinical trials so that further well-designed clinical research is needed to deepen their efficacy and safety profile.

R v Foy (Nicholas): voluntary intoxication, mental health and the case for diminished responsibility

2021 ◽  
Vol 72 (2) ◽  
Author(s):  
Bethany Simpson
Keyword(s):  
Mental Health ◽  
Expert Opinion ◽  
Evidence Based ◽  
Health Issues ◽  
Mental Health Issues ◽  
Court Of Appeal ◽  
Diminished Responsibility

In R v Foy, the appellant sought to adduce fresh evidence based on a difference in expert opinion. Dismissing the appeal, the Court of Appeal in England held that, where there is no solid basis for expert assertions, these appeals must fail. The case highlights the legal complexities intrinsic in diminished responsibility cases in the context of intoxication and mental health issues. This commentary addresses the legal ambiguities that arise under these circumstances.

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