Biosynthesis of mono-acylated mannosylerythritol lipid in an acyltransferase gene-disrupted mutant of Pseudozyma tsukubaensis

2017 ◽  
Vol 102 (4) ◽  
pp. 1759-1767 ◽  
Author(s):  
Azusa Saika ◽  
Yu Utashima ◽  
Hideaki Koike ◽  
Shuhei Yamamoto ◽  
Takahide Kishimoto ◽  
...  
Keyword(s):  
Mannosylerythritol Lipid ◽  
Pseudozyma Tsukubaensis

Biosynthesis of diastereomeric mannosylerythritol lipid using sugar-transferase from Pseudozyma tsukubaensis

2016 ◽  
Vol 33 ◽  
pp. S206
Author(s):  
Azusa Saika ◽  
Hideaki Koike ◽  
Tokuma Fukuoka ◽  
Shuhei Yamamoto ◽  
Takahide Kishimoto ◽  
...  
Keyword(s):  
Mannosylerythritol Lipid ◽  
Pseudozyma Tsukubaensis

scholarly journals Production of a Novel Mannosylerythritol Lipid Containing a Hydroxy Fatty Acid from Castor Oil by Pseudozyma tsukubaensis

2013 ◽  
Vol 62 (6) ◽  
pp. 381-389 ◽  
Author(s):  
Shuhei Yamamoto ◽  
Tokuma Fukuoka ◽  
Tomohiro Imura ◽  
Tomotake Morita ◽  
Shusaku Yanagidani ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Castor Oil ◽  
Hydroxy Fatty Acid ◽  
Mannosylerythritol Lipid ◽  
Pseudozyma Tsukubaensis

scholarly journals Identification of the gene PtMAT1 encoding acetyltransferase from the diastereomer type of mannosylerythritol lipid-B producer Pseudozyma tsukubaensis

2018 ◽  
Vol 126 (6) ◽  
pp. 676-681 ◽  
Author(s):  
Azusa Saika ◽  
Yu Utashima ◽  
Hideaki Koike ◽  
Shuhei Yamamoto ◽  
Takahide Kishimoto ◽  
...  
Keyword(s):  
Mannosylerythritol Lipid ◽  
Pseudozyma Tsukubaensis

scholarly journals Synthesis, Characterization of Liposomes Modified with Biosurfactant MEL-A Loading Betulinic Acid and Its Anticancer Effect in HepG2 Cell

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3939 ◽  
Author(s):  
Qin Shu ◽  
Jianan Wu ◽  
Qihe Chen
Keyword(s):  
Betulinic Acid ◽  
Hepg2 Cells ◽  
Lipid A ◽  
Clinical Applications ◽  
Dose Effect ◽  
Anticancer Effect ◽  
Mannosylerythritol Lipid ◽  
Anti Cancer ◽  
Effect Relation

As a novel natural compound delivery system, liposomes are capable of incorporating lipophilic bioactive compounds with enhanced compound solubility, stability and bioavailability, and have been successfully translated into real-time clinical applications. To construct the soy phosphatidylcholine (SPC)–cholesterol (Chol) liposome system, the optimal formulation was investigated as 3:1 of SPC to Chol, 10% mannosylerythritol lipid-A (MEL-A) and 1% betulinic acid. Results show that liposomes with or without betulinic acid or MEL-A are able to inhibit the proliferation of HepG2 cells with a dose-effect relation remarkably. In addition, the modification of MEL-A in liposomes can significantly promote cell apoptosis and strengthen the destruction of mitochondrial membrane potential in HepG2 cells. Liposomes containing MEL-A and betulinic acid have exhibited excellent anticancer activity, which provide factual basis for the development of MEL-A in the anti-cancer applications. These results provide a design thought to develop delivery liposome systems carrying betulinic acid with enhanced functional and pharmaceutical attributes.

Isolation of YeastKurtzmanomycessp. I-11, Novel Producer of Mannosylerythritol Lipid

2002 ◽  
Vol 66 (1) ◽  
pp. 188-191 ◽  
Author(s):  
Koji KAKUGAWA ◽  
Masahiro TAMAI ◽  
Kunihiko IMAMURA ◽  
Keiko MIYAMOTO ◽  
Shozo MIYOSHI ◽  
...  
Keyword(s):  
Mannosylerythritol Lipid ◽  
I 11
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