C16-Fengycin A affect the growth of Candida albicans by destroying its cell wall and accumulating reactive oxygen species

2019 ◽  
Vol 103 (21-22) ◽  
pp. 8963-8975 ◽  
Author(s):  
Yanan Liu ◽  
Jing Lu ◽  
Jing Sun ◽  
Xiaoyu Zhu ◽  
Libang Zhou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Wall ◽  
Candida Albicans ◽  
Reactive Oxygen ◽  
Oxygen Species

Antifungal activity of novel synthetic peptides by accumulation of reactive oxygen species (ROS) and disruption of cell wall against Candida albicans

Peptides ◽  
2011 ◽  
Vol 32 (8) ◽  
pp. 1732-1740 ◽  
Author(s):  
Indresh Kumar Maurya ◽  
Sarika Pathak ◽  
Monika Sharma ◽  
Hina Sanwal ◽  
Preeti Chaudhary ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Wall ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Synthetic Peptides ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Live Candida albicans Suppresses Production of Reactive Oxygen Species in Phagocytes

2008 ◽  
Vol 77 (1) ◽  
pp. 405-413 ◽  
Author(s):  
Melanie Wellington ◽  
Kristy Dolan ◽  
Damian J. Krysan
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Wall ◽  
Candida Albicans ◽  
Initial Point ◽  
Reactive Oxygen ◽  
Sublethal Dose ◽  
Ros Production ◽  
Oxygen Species ◽  
Murine Bone Marrow

ABSTRACT Production of reactive oxygen species (ROS) is an important aspect of phagocyte-mediated host responses. Since phagocytes play a crucial role in the host response to Candida albicans, we examined the ability of Candida to modulate phagocyte ROS production. ROS production was measured in the murine macrophage cell line J774 and in primary phagocytes using luminol-enhanced chemiluminescence. J774 cells, murine polymorphonuclear leukocytes (PMN), human monocytes, and human PMN treated with live C. albicans produced significantly less ROS than phagocytes treated with heat-killed C. albicans. Live C. albicans also suppressed ROS production in murine bone marrow-derived macrophages from C57BL/6 mice, but not from BALB/c mice. Live C. albicans also suppressed ROS in response to external stimuli. C. albicans and Candida glabrata suppressed ROS production by phagocytes, whereas Saccharomyces cerevisiae stimulated ROS production. The cell wall is the initial point of contact between Candida and phagocytes, but isolated cell walls from both heat-killed and live C. albicans stimulated ROS production. Heat-killed C. albicans has increased surface exposure of 1,3-β-glucan, a cell wall component that can stimulate phagocytes. To determine whether surface 1,3-β-glucan exposure accounted for the difference in ROS production, live C. albicans cells were treated with a sublethal dose of caspofungin to increase surface 1,3-β-glucan exposure. Caspofungin-treated C. albicans was fully able to suppress ROS production, indicating that suppression of ROS overrides stimulatory signals from 1,3-β-glucan. These studies indicate that live C. albicans actively suppresses ROS production in phagocytes in vitro, which may represent an important immune evasion mechanism.

scholarly journals Cell Wall Damage-Induced Lignin Biosynthesis Is Regulated by a Reactive Oxygen Species- and Jasmonic Acid-Dependent Process in Arabidopsis

2011 ◽  
Vol 156 (3) ◽  
pp. 1364-1374 ◽  
Author(s):  
Lucinda Denness ◽  
Joseph Francis McKenna ◽  
Cecile Segonzac ◽  
Alexandra Wormit ◽  
Priya Madhou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Wall ◽  
Jasmonic Acid ◽  
Reactive Oxygen ◽  
Lignin Biosynthesis ◽  
Oxygen Species ◽  
Cell Wall Damage ◽  
Dependent Process

scholarly journals Candida albicans Biofilms Do Not Trigger Reactive Oxygen Species and Evade Neutrophil Killing

2012 ◽  
Vol 206 (12) ◽  
pp. 1936-1945 ◽  
Author(s):  
Z. Xie ◽  
A. Thompson ◽  
T. Sobue ◽  
H. Kashleva ◽  
H. Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Candida Albicans ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Candida Albicans Biofilms

scholarly journals Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Katrijn De Brucker ◽  
Anna Bink ◽  
Els Meert ◽  
Bruno P. A. Cammue ◽  
Karin Thevissen
Keyword(s):  
Reactive Oxygen Species ◽  
Superoxide Dismutase ◽  
Candida Albicans ◽  
Amphotericin B ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Superoxide Dismutases ◽  
Antibiofilm Activity ◽  
Oxygen Species ◽  
Ammonium Tetrathiomolybdate

This study demonstrates a role for superoxide dismutases (Sods) in governing tolerance ofCandida albicansbiofilms to amphotericin B (AmB). Coincubation ofC. albicansbiofilms with AmB and the Sod inhibitors N,N′-diethyldithiocarbamate (DDC) or ammonium tetrathiomolybdate (ATM) resulted in reduced viable biofilm cells and increased intracellular reactive oxygen species levels as compared to incubation of biofilm cells with AmB, DDC, or ATM alone. Hence, Sod inhibitors can be used to potentiate the activity of AmB againstC. albicansbiofilms.

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