Molecular analysis of the Aureobasidium pullulans ura3 gene encoding orotidine-5′-phosphate decarboxylase and isolation of mutants defective in this gene

2000 ◽  
Vol 53 (3) ◽  
pp. 296-300 ◽  
Author(s):  
K. Rose ◽  
M. Liebergesell ◽  
A. Steinbüchel
2009 ◽  
Vol 152 (1) ◽  
pp. 71-84 ◽  
Author(s):  
Ana-Rosa Ballester ◽  
Jos Molthoff ◽  
Ric de Vos ◽  
Bas te Lintel Hekkert ◽  
Diego Orzaez ◽  
...  

1991 ◽  
Vol 230 (1-2) ◽  
pp. 332-336 ◽  
Author(s):  
Hisami Yamada ◽  
Takayuki Yoshida ◽  
Ken-ichi Tanaka ◽  
Chihiro Sasakawa ◽  
Takeshi Mizuno

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Tatiana M. Villatoro ◽  
Stacey K. Mardekian

Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of β-catenin, similar to other tumors that show this type of metaplasia, but the underlying mechanism responsible for this finding is not completely understood. We present two cases of low-grade non-ITAC with squamoid morules coexpressing CDX2 and nuclear β-catenin by immunohistochemistry, both of which were found to harbor a mutation in CTNNB1, the gene encoding β-catenin. This finding provides support that an alteration in the β-catenin pathway, including mutations in the β-catenin gene itself, is responsible for this recently described morphologic phenomenon in non-ITAC.


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