Giant cell tumor of bone in a patient with diagnosis of primary hyperparathyroidism: a challenge in differential diagnosis with brown tumor

2013 ◽  
Vol 43 (5) ◽  
pp. 693-697 ◽  
Author(s):  
Barbara Rossi ◽  
Virginia Ferraresi ◽  
Maria Luisa Appetecchia ◽  
Mariangela Novello ◽  
Carmine Zoccali
Keyword(s):  
Differential Diagnosis ◽  
Primary Hyperparathyroidism ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Brown Tumor

Giant-cell tumor of the sphenoid bone

1983 ◽  
Vol 59 (2) ◽  
pp. 322-327 ◽  
Author(s):  
James T. Wolfe ◽  
Bernd W. Scheithauer ◽  
David C. Dahlin
Keyword(s):  
Differential Diagnosis ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
World Literature ◽  
Bone Cyst ◽  
Cell Tumor ◽  
Sphenoid Bone ◽  
Visual Field Defects ◽  
Brown Tumor ◽  
Postoperative Radiation Therapy

✓ Giant-cell tumor rarely affects the sphenoid bone. Ten cases of this tumor seen at the Mayo Clinic are reviewed, bringing the number of cases in the world literature to 31. These tumors, which present in the second and third decades of life and are slightly more frequent in women than in men, may present with various symptoms, including headache, visual field defects, blindness, and diplopia. The symptom complex and roentgenographic findings are seldom, if ever, sufficiently characteristic to allow preoperative diagnosis. The microscopic differential diagnosis of giant-cell tumor of the sphenoid region includes giant-cell reparative granuloma, aneurysmal bone cyst, fibrous dysplasia, and “brown tumor” of hyperparathyroidism. Interesting features of this series include the presence of multifocal giant-cell tumor in one case, and the absence of Paget's disease of bone in every case. Complete follow-up review in these cases allowed a discussion of therapy and prognosis; it appears that subtotal excision with postoperative radiation therapy is the treatment of choice. While the histological appearance of giant-cell tumor is characteristic, caution must be exercised in interpreting small samples, and various reparative and metabolic disorders must be considered in the differential diagnosis.

scholarly journals Brown Tumor of the Facial Bones: Case Report and Literature Review

2005 ◽  
Vol 84 (7) ◽  
pp. 432-434 ◽  
Author(s):  
Marcus M. Lessa ◽  
Flavio A. Sakae ◽  
Robinson K. Tsuji ◽  
Bernardo C. Araújo Filho ◽  
Richard L. Voegels ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Surgical Resection ◽  
Tumor Regression ◽  
Cell Tumor ◽  
Nasal Fossa ◽  
Laboratory Evaluation ◽  
Direct Result ◽  
Brown Tumor ◽  
The Right

Brown tumor, an uncommon focal giant-cell lesion, arises as a direct result of the effect of parathyroid hormone on bone tissue in patients with hyperparathyroidism. The initial treatment involves the correction of hyperparathyroidism, which usually leads to tumor regression. We report a case of brown tumor of the right nasal fossa in a 71-year-old woman. The tumor had caused nasal obstruction and epistaxis. Laboratory evaluation revealed that the patient had primary hyperparathyroidism. Anatomicopathologic investigation revealed the presence of a giant-cell tumor. We performed a partial parathyroidectomy, but the tumor in the right nasal fossa failed to regress. One year later, we performed surgical resection of the lesion. The patient recovered uneventfully, and she remained asymptomatic and recurrence-free at the 1-year follow-up. Facial lesions with histologic features of a giant-cell tumor should be evaluated from a systemic standpoint. Hyperparathyroidism should always be investigated by laboratory tests because most affected patients are asymptomatic. Surgical resection of a brown tumor should be considered if the mass does not regress after correction of the inciting hyperparathyroidism or if the patient is highly symptomatic.

scholarly journals Giant Cell Tumor of the Sphenoid Bone

1977 ◽  
Vol 4 (3) ◽  
pp. 213-216 ◽  
Author(s):  
Rasikbala Doshi ◽  
Abdul Basit Chaudhari ◽  
Gordon Thomson
Keyword(s):  
Differential Diagnosis ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Sphenoid Bone ◽  
Histological Features ◽  
Symptoms And Signs

SUMMARY:The clinical and histological features of two cases of giant cell tumor of the sphenoid bone are described. Both presented with similar symptoms and signs, comparable to previously described cases. The problems in histological differential diagnosis are discussed and radiotherapy as the treatment of choice is suggested.

scholarly journals Analysis of High-Frequency Ultrasound in the differential Diagnosis of Lumps in Foot and Hand

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Huitong Yan ◽  
Heying Li ◽  
Jianmei Han ◽  
Jianmei Han ◽  
Yingbo Tang
Keyword(s):  
Differential Diagnosis ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Epidermoid Cyst ◽  
High Frequency ◽  
Preoperative Diagnosis ◽  
Tendon Sheath ◽  
Cell Tumor ◽  
High Frequency Ultrasound ◽  
Frequency Ultrasound

Objective: To investigate the ultrasonogram characteristics of common lumps in hand and foot, pursuing for greater understanding of hand and foot lumps. Methods: 65 cases of ultrasonographic characteristics of lumps in hand and foot were retrospectively analyzed, including the location, size, shape, boundary, internal echo and posterior echo, surrounding relationship and blood flow. Results: Among 65 cases, there were 26 cases of tendon sheath cyst, 16 cases of tenosynovitis giant cell tumor, 10 cases of hemangioma, 4 cases of tendon sheath fibroma, 3 cases of epidermoid cyst, 2 cases of Schwannoma, 2 cases of fibrolipoma, 1 case of angiolipoma and 1 case of neurofibroma. The preoperative and postoperative pathological diagnoses of 45 cases, accounting for 69.23%, were consistent, 3 cases (4.62%) were misdiagnosed, which included that 2 cases of tenosynovitis giant cell tumor were misdiagnosed as tendon sheath cyst, 1 case of neurofibroma as epidermoid cyst, and the preoperative diagnosis of the rest 17 cases(26.15%) were indefinite. Conclusion: The high-frequency ultrasound can diagnose properties of lumps in foot and hand well, providing diagnosis basis for further treatment in clinic.

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