NTRK-rearranged spindle cell neoplasm of the lower extremity: radiologic-pathologic correlation

Abstract A 4-year-old female captive-bred snake of the genus Bothrops showed swelling on the left side of the oral cavity, suggesting the development of neoplasia. The mass was removed surgically and sent for pathological examination. Two months later a new increase in volume in the same site was observed, suggesting recurrence. The lesion was completely removed and sent for pathological analysis. Histologically, the two-samples consisted of a mass with highly-cell density composed of spindle-shaped anaplastic cells arranged in interwoven bundles, distributed throughout the tissue extension and, occasionally, polygonal cells arranged in irregular fascicles. The Masson trichrome staining showed modest amount of collagen supporting the neoplastic cells. PAS-positive content was not observed in the cytoplasm of neoplastic cells. Histological and histochemical findings indicated that it was a spindle cell neoplasm, but the classification was not possible. Immunohistochemistry was requested and performed using the streptavidin-biotin-peroxidase method. The markers used were anti-vimentin, anti-PCNA, anti-EMA, anti-melan A and anti-melanosome, anti-desmin, anti-actin, anti-CD68 and anti- S100protein. The neoplastic cells were immunoreactive for vimentin and PCNA and negative for the other antibodies. The morphology characterization, histochemical and immunohistochemical analysis of neoplastic cells allowed the definitive diagnosis of oral fibrosarcoma.

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Sclerosing peritonitis associated with gynecological tumors: IgG4 peritoneal disease or a low grade spindle cell neoplasm?

Human Pathology Case Reports ◽

10.1016/j.ehpc.2020.200354 ◽

2020 ◽

Vol 20 ◽

pp. 200354

Author(s):

Mary Anne Brett ◽

Monica Rodriguez ◽

Máire A. Duggan

Keyword(s):

Spindle Cell ◽

Low Grade ◽

Peritoneal Disease ◽

Gynecological Tumors ◽

Sclerosing Peritonitis ◽

Spindle Cell Neoplasm ◽

Cell Neoplasm

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Myofibroma of the oral cavity. A rare spindle cell neoplasm

Medicina Oral Patología Oral y Cirugia Bucal ◽

10.4317/medoral.15.e596 ◽

2010 ◽

pp. e596-e600 ◽

Cited By ~ 11

Author(s):

BF. Brasileiro ◽

PR. Martins-Filho ◽

MR. Piva ◽

LC. da Silva ◽

CF. Nonaka ◽

...

Keyword(s):

Oral Cavity ◽

Spindle Cell ◽

Spindle Cell Neoplasm ◽

Cell Neoplasm

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Myopericytoma of the Neck Originating in the Middle Scalene Muscle: A Case Report

Ear Nose & Throat Journal ◽

10.1177/0145561317096010-1102 ◽

2017 ◽

Vol 96 (10-11) ◽

pp. E5-E7 ◽

Cited By ~ 1

Author(s):

Mark B. Chaskes ◽

John W. Bishop ◽

Matthew Bobinski ◽

D. Gregory Farwell

Keyword(s):

Needle Biopsy ◽

Spindle Cell ◽

Tissue Sample ◽

Surgical Excision ◽

Scalene Muscle ◽

Spindle Cell Neoplasm ◽

Sensory Deficits ◽

Complete Surgical Excision ◽

Supraclavicular Fossa ◽

Cell Neoplasm

We report a case of myopericytoma of the neck. A 23-year-old woman noticed a small, nontender mass in her left supraclavicular fossa. The mass had grown over a period of 5 months, prompting her to seek evaluation. On examination, no motor or sensory deficits were present. Imaging suggested that a mass had originated in the middle scalene muscle. Computed-tomography–guided core needle biopsy demonstrated a spindle-cell neoplasm with smooth-muscle differentiation. Complete surgical excision was performed. Histopathologic and immunohistochemical evaluations of the tissue sample suggested a myopericytoma. Myopericytoma is an extremely rare tumor of the head and neck. To the best of our knowledge, this is the first reported case of a myopericytoma originating in a scalene muscle.

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Solitary Fibrous Tumor of the Kidney. A Propos of a Case

Urologia Journal ◽

10.1177/039156030907600214 ◽

2009 ◽

Vol 76 (2) ◽

pp. 112-114 ◽

Cited By ~ 1

Author(s):

M. Marzi ◽

M. D'Alpaos ◽

P. Piras ◽

A. Paiusco ◽

M.S. Minervini ◽

...

Keyword(s):

Solitary Fibrous Tumor ◽

Renal Pelvis ◽

Spindle Cell ◽

Left Kidney ◽

Clinical Behavior ◽

Spindle Cell Neoplasm ◽

Solitary Fibrous Tumors ◽

Genital Apparatus ◽

Cell Neoplasm ◽

Fibrous Tumor

Solitary Fibrous Tumors (SFT) are rare spindle cell neoplasm that typically originate from the pleura. However, cases of the SFT are described with origin in other organs, including the urinary and genital apparatus. Within the kidney, except from the renal pelvis, only 19 cases of SFT are described and such rarity of localization makes the histogenesis and the prognosis of the tumor rather unknown. We report the case of a 72-year-old lady who attended our Unit for a mass that was clinically palpable at the level of the left hemiabdomen. The tomodensitographic test indicated a 19cm-diameter mass of likely pertinence of the middle bystender of the left kidney. She had undergone left radical nephrectomy. The histological examination highlighted a solitary fibrous tumor (SFT): the presence of hypercellularity, of cellular pleiomorphism and of a high number of mitosis has led to a histological diagnosis of malignancy for the neoplasm analyzed. The SFT are of rare clinical comparison: this does not allow for a deep knowledge of the lesion histogenesis and prognosis; moreover, the clinical behavior should be more precisely defined.

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Myopericytoma of the Neck Originating From the Middle Scalene: A Case Report

Ear Nose & Throat Journal ◽

10.1177/0145561319839821 ◽

2019 ◽

Vol 99 (7) ◽

pp. NP72-NP74

Author(s):

Mark B. Chaskes ◽

John W. Bishop ◽

Matthew Bobinski ◽

D. Gregory Farwell

Keyword(s):

Needle Biopsy ◽

Spindle Cell ◽

Tissue Sample ◽

Surgical Excision ◽

Scalene Muscle ◽

Spindle Cell Neoplasm ◽

Sensory Deficits ◽

Complete Surgical Excision ◽

Supraclavicular Fossa ◽

Cell Neoplasm

We report the case of a myopericytoma of the neck. A 23-year-old female noticed a small, nontender mass in her left supraclavicular fossa. The mass grew over a period of 5 months, prompting the patient to seek evaluation. There were no motor or sensory deficits. Imaging suggested a mass originating from the middle scalene muscle. Computed tomography–guided core needle biopsy demonstrated a spindle cell neoplasm with smooth muscle differentiation. Complete surgical excision was performed. Histopathological and immunohistochemical evaluation of the tissue sample suggested myopericytoma. Myopericytoma is an extremely rare tumor of the head and neck. To our knowledge, this is the first reported case of a myopericytoma originating from a scalene muscle.

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Solitary Fibrous Tumor of the Kidney: A Case Report

Case Reports in Urology ◽

10.1155/2013/147496 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4

Author(s):

Abdullah Demirtaş ◽

Volkan Sabur ◽

Hülya Akgün ◽

Emre Can Akınsal ◽

Deniz Demirci

Keyword(s):

Solitary Fibrous Tumor ◽

Cystic Lesion ◽

Spindle Cell ◽

Left Kidney ◽

Ki 67 ◽

Spindle Cell Neoplasm ◽

Cell Neoplasm ◽

Fibrous Tumor ◽

Immunohistochemical Studies ◽

Hmb 45

Solitary fibrous tumor is a spindle cell neoplasm mostly originating from pleura; however, it has also recently been reported to be extrapleural. A 57-year-old man presented with left lumbal pain. Ultrasonography and computed tomography showed a cystic lesion of 14 × 11 cm with solid areas and septations in middle and lower poles of the left kidney. Radical nephrectomy was performed. Immunohistochemical studies showed strong reactions with CD34 and CD99. A nuclear positivity with Ki-67 was observed in less than 1% of cells. Despite repeated stainings with vimentin, no clear tumor evaluation could be made due to artifacts. The tumor was negative with Bcl-2, desmin, HMB-45, S100, FVIII, and CD31. Histopathological and molecular studies made the diagnosis of a solitary fibrous tumor. The patient is now currently free of disease at the 26th month of followup.

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