scholarly journals Clinical performance of long axial field of view PET/CT: a head-to-head intra-individual comparison of the Biograph Vision Quadra with the Biograph Vision PET/CT

2021 ◽  
Author(s):  
Ian Alberts ◽  
Jan-Niklas Hünermund ◽  
George Prenosil ◽  
Clemens Mingels ◽  
Karl Peter Bohn ◽  
...  
Keyword(s):  
Image Quality ◽  
Low Dose ◽  
Clinical Performance ◽  
Visual Image ◽  
Target Lesion ◽  
Field Of View ◽  
List Mode ◽  
Axial Field ◽  
Individual Comparison ◽  
Pet Ct

Abstract Purpose To investigate the performance of the new long axial field-of-view (LAFOV) Biograph Vision Quadra PET/CT and a standard axial field-of-view (SAFOV) Biograph Vision 600 PET/CT (both: Siemens Healthineers) system using an intra-patient comparison. Methods Forty-four patients undergoing routine oncological PET/CT were prospectively included and underwent a same-day dual-scanning protocol following a single administration of either 18F-FDG (n = 20), 18F-PSMA-1007 (n = 16) or 68Ga-DOTA-TOC (n = 8). Half the patients first received a clinically routine examination on the SAFOV (FOVaxial 26.3 cm) in continuous bed motion and then immediately afterwards on the LAFOV system (10-min acquisition in list mode, FOVaxial 106 cm); the second half underwent scanning in the reverse order. Comparisons between the LAFOV at different emulated scan times (by rebinning list mode data) and the SAFOV were made for target lesion integral activity, signal to noise (SNR), target lesion to background ratio (TBR) and visual image quality. Results Equivalent target lesion integral activity to the SAFOV acquisitions (16-min duration for a 106 cm FOV) were obtained on the LAFOV in 1.63 ± 0.19 min (mean ± standard error). Equivalent SNR was obtained by 1.82 ± 1.00 min LAFOV acquisitions. No statistically significant differences (p > 0.05) in TBR were observed even for 0.5 min LAFOV examinations. Subjective image quality rated by two physicians confirmed the 10 min LAFOV to be of the highest quality, with equivalence between the LAFOV and the SAFOV at 1.8 ± 0.85 min. By analogy, if the LAFOV scans were maintained at 10 min, proportional reductions in applied radiopharmaceutical could obtain equivalent lesion integral activity for activities under 40 MBq and equivalent doses for the PET component of <1 mSv. Conclusion Improved image quality, lesion quantification and SNR resulting from higher sensitivity were demonstrated for an LAFOV system in a head-to-head comparison under clinical conditions. The LAFOV system could deliver images of comparable quality and lesion quantification in under 2 min, compared to routine SAFOV acquisition (16 min for equivalent FOV coverage). Alternatively, the LAFOV system could allow for low-dose examination protocols. Shorter LAFOV acquisitions (0.5 min), while of lower visual quality and SNR, were of adequate quality with respect to target lesion identification, suggesting that ultra-fast or low-dose acquisitions can be acceptable in selected settings.

scholarly journals Feasibility of late acquisition [68Ga]Ga-PSMA-11 PET/CT using a long axial field-of-view PET/CT scanner for the diagnosis of recurrent prostate cancer—first clinical experiences

2021 ◽  
Author(s):  
Ian Alberts ◽  
George Prenosil ◽  
Clemens Mingels ◽  
Karl Peter Bohn ◽  
Marco Viscione ◽  
...  
Keyword(s):  
Image Quality ◽  
Case Series ◽  
Likert Scale ◽  
Target Lesion ◽  
Field Of View ◽  
Ct Scanner ◽  
Axial Field ◽  
Retrospective Case ◽  
Imaging Quality ◽  
Pet Ct

Abstract Purpose While acquisition of images in [68 Ga]Ga-PSMA-11 following longer uptake times can improve lesion uptake and contrast, resultant imaging quality and count statistics are limited by the isotope’s half-life (68 min). Here, we present a series of cases demonstrating that when performed using a long axial field-of-view (LAFOV) PET/CT system, late imaging is feasible and can even provide improved image quality compared to regular acquisitions. Methods In this retrospective case series, we report our initial experiences with 10 patients who underwent standard imaging at 1 h p.i. following administration of 192 ± 36 MBq [68 Ga]Ga-PSMA-11 with additional late imaging performed at 4 h p.i. Images were acquired in a single bed position for 6 min at 1 h p.i. and 16 min p.i. at 4 h p.i. using a LAFOV scanner (106 cm axial FOV). Two experienced nuclear medicine physicians reviewed all scans in consensus and evaluated overall image quality (5-point Likert scale), lesion uptake in terms of standardised uptake values (SUV), tumour to background ratio (TBR) and target-lesion signal to background noise (SNR). Results Subjective image quality as rated on a 5-point Likert scale was only modestly lower for late acquisitions (4.2/5 at 4 h p.i.; 5/5 1 h p.i.), TBR was significantly improved (4 h: 3.41 vs 1 h: 1.93, p < 0.001) and SNR was improved with borderline significance (4 h: 33.02 vs 1 h: 24.80, p = 0.062) at later imaging. Images were obtained with total acquisition times comparable to routine examinations on standard axial FOV scanners. Conclusion Late acquisition in tandem with a LAFOV PET/CT resulted in improvements in TBR and SNR and was associated with only modest impairment in subjective visual imaging quality. These data show that later acquisition times for [68 Ga]Ga-PSMA-11 may be preferable when performed on LAFOV systems.

scholarly journals The effect of modern PET technology and techniques on the EANM paediatric dosage card

2021 ◽  
Author(s):  
John Dickson ◽  
Uta Eberlein ◽  
Michael Lassmann
Keyword(s):  
Image Quality ◽  
Field Of View ◽  
Published Data ◽  
Axial Field ◽  
Short Article ◽  
Pet Ct ◽  
Class B ◽  
Total Body ◽  
Bed Position ◽  
Pet Scanners

Abstract Aim Recent advancements in PET technology have brought with it significant improvements in PET performance and image quality. In particular, the extension of the axial field of view of PET systems, and the introduction of semiconductor technology into the PET detector, initially for PET/MR, and more recently available long-field-of-view PET/CT systems (≥ 25 cm) have brought a step change improvement in the sensitivity of PET scanners. Given the requirement to limit paediatric doses, this increase in sensitivity is extremely welcome for the imaging of children and young people. This is even more relevant with PET/MR, where the lack of CT exposures brings further dose reduction benefits to this population. In this short article, we give some details around the benefits around new PET technology including PET/MR and its implications on the EANM paediatric dosage card. Material and methods  Reflecting on EANM adult guidance on injected activities, and making reference to bed overlap and the concept of MBq.min bed−1 kg−1, we use published data on image quality from PET/MR systems to update the paediatric dosage card for PET/MR and extended axial field of view (≥ 25 cm) PET/CT systems. However, this communication does not cover the expansion of paediatric dosing for the half-body and total-body scanners that have recently come to market. Results In analogy to the existing EANM dosage card, new parameters for the EANM paediatric dosage card were developed (class B, baseline value: 10.7 MBq, minimum recommended activity 10 MBq). The recommended administered activities for the systems considered in this communication range from 11 MBq [18F]FDG for a child with a weight of 3 kg to 149 MBq [18F]FDG for a paediatric patient weight of 68 kg, assuming a scan of 3 min per bed position. The mean effective dose over all ages (1 year and older) is 2.85 mSv. Conclusion With this, recommendations for paediatric dosing are given for systems that have not been considered previously.

Clinical performance of an ultra-long axial field of view PET/CT: a head-to-head comparison with a regular digital PET/CT

2021 ◽  
Author(s):  
I Alberts ◽  
BO Vollnberg ◽  
M Viscione ◽  
H Sari ◽  
A Afshar-Oromieh ◽  
...  
Keyword(s):  
Clinical Performance ◽  
Field Of View ◽  
Axial Field ◽  
Pet Ct ◽  
Digital Pet

Image quality and lesion detectability in low-dose pediatric 18F-FDG scans using total-body PET/CT

2021 ◽  
Author(s):  
Yu-Mo Zhao ◽  
Ying-He Li ◽  
Tao Chen ◽  
Wei-Guang Zhang ◽  
Lin-Hao Wang ◽  
...  
Keyword(s):  
Image Quality ◽  
Low Dose ◽  
Lesion Detectability ◽  
Pet Ct ◽  
18F Fdg ◽  
Total Body

scholarly journals The Impact of Varying Number of OSEM Iterations on Standardized Uptake Value and Image Quality of Discovery STE PET/CT Scanner

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 68s-68s
Author(s):  
B. Ali ◽  
A. Afshan ◽  
M.B. Kakakhel
Keyword(s):  
Image Quality ◽  
Standardized Uptake Value ◽  
Acquisition Time ◽  
List Mode ◽  
Ct Scanner ◽  
Matrix Size ◽  
Cold Lesion ◽  
Pet Ct ◽  
The Impact

Background: In PET imaging both quantitative and qualitative interpretations are used. Qualitative and quantitative interpretations depend upon PET/CT image quality that along with many biologic factors strongly depends upon image reconstruction parameters. Aim: The objective of this experimental work was to study the impact of one of the key reconstruction parameter, i.e., number of reconstruction iteration, on standardized uptake value and image quality of PET/CT scan. Methods: Images of NEMA IEC Image Quality Phantom were acquired in list mode for 10 mins on Discovery STE PET/CT scanner, using tumor to background ratio of 4:1 and 18F-FDG as radiotracer. List mode data were further transformed into data sets of varying acquisition time (0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0 mins) per bed position. Transformed data set of 5.0 mins were used to study the impact of varying number of iterations (2, 3, 4, 5, 7, 10, 15, 20) using OSEM approach of iterative reconstruction. Standardized uptake value (SUV) and underestimation in SUV were calculated as quantitative measures, while hot lesion contrast, cold lesion contrast and background variability were calculated as qualitative measures. Results: Standardized uptake value, hot and cold lesion contrast, image spatial resolution and background variability showed increasing trend with increase in reconstruction iterations. Maximum increase of 20.25%, 16.33%, 9.79% and 6.88% was observed in SUV for 10 mm, 13 mm, 17 mm and 22 mm lesions as number of iteration change from 2 to 3. Smallest and the largest diameter lesions showed maximum underestimations of 54.67% and 8.20% at 2 iterations respectively. Percentage hot lesion contrast showed rapid increase as the number of iteration change from 2 to 7 and increased slowly afterward. Background variability range from 4.4% to 6.4%, 4.1%–5.7%, 3.6%–4.6%, 3%–3.8%, 2.7%–3.2%, 2.4%–2.7% for 10.0 mm, 13.0 mm, 17.0 mm, 22.0 mm, 28.0 mm and 37.0 mm sphere respectively. Conclusion: Optimized reconstruction parameters for routine clinical studies 3 iterations with image matrix size of 128 × 128 with filters FWHM of 6 mm and for high resolution studies 3 iterations image matrix size of 256×256 with filters FWHM of 6 mm.

Can a Deep Progressive Learning Method Help to Achieve High Image Quality as Total-body PET Imaging?

2021 ◽  
Author(s):  
Taisong Wang ◽  
Wenli Qiao ◽  
Ying Wang ◽  
Jingyi Wang ◽  
Yang Lv ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Image Quality ◽  
Prospective Study ◽  
Real World ◽  
Low Dose ◽  
Acquisition Time ◽  
Learning Method ◽  
List Mode ◽  
Total Body ◽  
Progressive Learning

Abstract Purpose To propose and validate a total-body PET (TB-PET) guided deep progressive learning method (DPR) for low-dose clinical imaging of standard axial field-of-view PET/CT scanner (SAFOV-PET).Methods List-mode raw data from a total of 182 scans were collected, including 100 patient scans from a TB-PET, and 15 phantom and 67 patient scans from a SAFOV-PET. Neural networks employed in DPR were trained with the high-quality images obtained from the TB-PET using a progressive learning strategy and evaluated on a SAFOV-PET through three stages of studies. The CTN phantom was firstly used to verify the effectiveness of protocols in DPR and OSEM algorithms. Subsequently, list-mode rawdata from retrospective and prospective PET oncological patients (n=26 and 41, respectively) were rebinned into short duration scans (referred as to DPR_full, DPR_1/2, DPR_1/3, and DPR_1/4), and reconstructed with DPR. Full-duration data were reconstructed with OSEM to generate images as a reference. In the retrospective study, the image quality was evaluated using the metrics of standard uptake value (SUV) and target-to-liver ratio (TLR) in lesions, and coefficient of variation (COV) in the liver, which provided evidence for the subsequent study with real-world low-dose injection. In the prospective study, the quantification accuracy was evaluated with the agreement of SUVs in the liver, the blood pool, and the muscle between the DPR and the OSEM images. Quantitative analysis was also performed with the SUV and the TLR in lesions, furthermore on small lesions with a diameter no more than 10mm. In addition, qualitative analysis was performed using a 5-point Likert scale on the following perspectives: contrast, noise, and diagnostic confidence. Results The protocols used in the study were verified to meet the EANM EARL2 requirements. In the retrospective study, the DPR group with one-third acquisition time can yield a comparable image quality to the reference. In the prospective study, good agreement of the SUVs between DPR and OSEM was found in all the selected background tissues even if the injected dose was reduced to 1/3. Both quantitative and qualitative results demonstrated that the DPR_1/3 group showed no significant difference with the reference regarding the liver COV and subjective scores. The lesion SUVs and TLRs in the DPR_1/3 group were significantly enhanced compared with the reference, even for small lesions. Conclusions The proposed DPR method can reduce the injected dose of SAFOV-PET scan by up to 2/3 in a real-world deployment while maintaining image quality.

scholarly journals Performance evaluation of the uEXPLORER Total-body PET/CT scanner based on NEMA NU 2-2018 with additional tests to characterize long axial field-of-view PET scanners

2020 ◽  
pp. jnumed.120.250597 ◽  
Author(s):  
Benjamin A. Spencer ◽  
Eric Berg ◽  
Jeffrey P. Schmall ◽  
Negar Omidvari ◽  
Edwin K. Leung ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Field Of View ◽  
Ct Scanner ◽  
Axial Field ◽  
Pet Ct ◽  
Total Body ◽  
Pet Scanners

The effect of activity outside the field of view on image quality for a 3D LSO-based whole body PET/CT scanner

2009 ◽  
Vol 54 (19) ◽  
pp. 5861-5872 ◽  
Author(s):  
R Matheoud ◽  
C Secco ◽  
P Della Monica ◽  
L Leva ◽  
G Sacchetti ◽  
...  
Keyword(s):  
Image Quality ◽  
Field Of View ◽  
Whole Body ◽  
Ct Scanner ◽  
Pet Ct

scholarly journals The effect of reduced scan time on response assessment FDG-PET/CT imaging using Deauville score in patients with lymphoma

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Charlotte Hornnes ◽  
Annika Loft ◽  
Liselotte Højgaard ◽  
Flemming Littrup Andersen
Keyword(s):  
Image Quality ◽  
Hodgkin Lymphoma ◽  
Fdg Pet ◽  
Response Assessment ◽  
Acquisition Time ◽  
List Mode ◽  
Deauville Score ◽  
Scan Time ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Purpose [18F]Fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) is used for response assessment during therapy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Clinicians report the scans visually using Deauville criteria. Improved performance in modern PET/CT scanners could allow for a reduction in scan time without compromising diagnostic image quality. Additionally, patient throughput can be increased with increasing cost-effectiveness. We investigated the effects of reducing scan time of response assessment FDG-PET/CT in HL and NHL patients on Deauville score (DS) and image quality. Methods Twenty patients diagnosed with HL/NHL referred to a response assessment FDG-PET/CT were included. PET scans were performed in list-mode with an acquisition time of 120 s per bed position(s/bp). From PET list-mode data images with full acquisition time of 120 s/bp and shorter acquisition times (90, 60, 45, and 30 s/bp) were reconstructed. All images were assessed by two specialists and assigned a DS. We estimated the possible savings when reducing scan time using a simplified model based on assumed values/costs for our hospital. Results There were no significant changes in the visually assessed DS when reducing scan time to 90 s/bp, 60 s/bp, 45 s/bp, and 30 s/bp. Image quality of 90 s/bp images were rated equal to 120 s/bp images. Coefficient of variance values for 120 s/bp and 90 s/bp images was significantly < 15%. The estimated annual savings to the hospital when reducing scan time was 8000-16,000 €/scanner. Conclusion Acquisition time can be reduced to 90 s/bp in response assessment FDG-PET/CT without compromising Deauville score or image quality. Reducing acquisition time can reduce costs to the clinic.

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