The prognostic value of myocardial perfusion scintigraphy: investigators, are you (mis)leading us?

2001 ◽  
Vol 28 (9) ◽  
pp. 1439-1446
Author(s):  
Judocus J. J. Borm ◽  
Hanneke Bouwsma ◽  
Ernst E. van der Wall ◽  
Ernest K. J. Pauwels
Author(s):  
Federico Caobelli ◽  
◽  
Philip Haaf ◽  
Gianluca Haenny ◽  
Matthias Pfisterer ◽  
...  

Abstract Background The Basel Asymptomatic High-Risk Diabetics’ Outcome Trial (BARDOT) demonstrated that asymptomatic diabetic patients with an abnormal myocardial perfusion scintigraphy (MPS) were at increased risk of major adverse cardiovascular events (MACEs) at 2-year follow-up. It remains unclear whether this finding holds true even for a longer follow-up. Methods Four hundred patients with type 2 diabetes, neither history nor symptoms of coronary artery disease (CAD), were evaluated clinically and with MPS. Patients were followed up for 5 years. Major adverse cardiovascular events (MACEs) were defined as all-cause death, myocardial infarction, or late coronary revascularization. Results At baseline, an abnormal MPS (SSS ≥ 4 or SDS ≥ 2) was found in 87 of 400 patients (22%). MACE within 5 years occurred in 14 patients with abnormal MPS (16.1%) and in 22 with normal scan (1.7%), p = 0.009; 15 deaths were recorded. Patients with completely normal MPS (SSS and SDS = 0) had lower rates of MACEs than patients with abnormal scans (2.5% vs. 7.0%, p = 0.032). Patients with abnormal MPS who had undergone revascularization had a lower mortality rate and a better event-free survival from MI and revascularization than patients with abnormal MPS who had either undergone medical therapy only or could not be revascularized (p = 0.002). Conclusions MPS may have prognostic value in asymptomatic diabetic patients at high cardiovascular risk over a follow-up period of 5 years. Patients with completely normal MPS have a low event rate and may not need retesting within 5 years. Patients with an abnormal MPS have higher event rates and may benefit from a combined medical and revascularization approach.


2001 ◽  
Vol 28 (9) ◽  
pp. 1299-1305
Author(s):  
Judocus J. J. Borm ◽  
Hanneke Bouwsma ◽  
Ernst E. van der Wall ◽  
Ernest K. J. Pauwels

2012 ◽  
Vol 39 (10) ◽  
pp. 1570-1580 ◽  
Author(s):  
Luca Nai Fovino ◽  
Giorgio Saladini ◽  
Anna Rita Cervino ◽  
Francesca Saladini ◽  
Michele Gregianin ◽  
...  

Author(s):  
E. López Rodríguez ◽  
B. Jauregui Garrido ◽  
J. Ruiz Franco-Baux ◽  
L. Caballero Gullón ◽  
A. Guisado Rasco ◽  
...  

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