Is there an added value of a hepatobiliary phase with gadoxetate disodium following conventional MRI with an extracellular gadolinium agent in a single imaging session for detection of primary hepatic malignancies?

2016 ◽  
Vol 41 (7) ◽  
pp. 1270-1284 ◽  
Author(s):  
Jay K. Pahade ◽  
David Juice ◽  
Lawrence Staib ◽  
Gary Israel ◽  
Dan Cornfeld ◽  
...  
Keyword(s):  
Added Value ◽  
Hepatobiliary Phase ◽  
Gadoxetate Disodium ◽  
Conventional Mri ◽  
Primary Hepatic Malignancies ◽  
Hepatic Malignancies

scholarly journals Added value of diffusion-weighted MRI in assessment of pleural lesions

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Youssriah Yahia Sabri ◽  
Ikram Hamed Mahmoud ◽  
Lamis Tarek El-Gendy ◽  
Mohamed Raafat Abd El-Mageed ◽  
Sally Fouad Tadros
Keyword(s):  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Diagnostic Value ◽  
Added Value ◽  
Adc Value ◽  
Pleural Diseases ◽  
Conventional Mri ◽  
Malignant Lesions

Abstract Background There are many causes of pleural disease including variable benign and malignant etiologies. DWI is a non-enhanced functional MRI technique that allows qualitative and quantitative characterization of tissues based on their water molecules diffusivity. The aim of this study was to evaluate the diagnostic value of DWI-MRI in detection and characterization of pleural diseases and its capability in differentiating benign from malignant pleural lesions. Results Conventional MRI was able to discriminate benign from malignant lesions by using morphological features (contour and thickness) with sensitivity 89.29%, specificity 76%, positive predictive value 89%, negative predictive value 76.92%, and accuracy 85.37%. ADC value as a quantitative parameter of DWI found that ADC values of malignant pleural diseases were significantly lower than that of benign lesions (P < 0.001). Hence, we discovered that using ADC mean value of 1.68 × 10-3 mm2/s as a cutoff value can differentiate malignant from benign pleural diseases with sensitivity 89.3%, specificity 100%, positive predictive value 100%, negative predictive value 81.2%, and accuracy 92.68% (P < 0.001). Conclusion Although DWI-MRI is unable to differentiate between malignant and benign pleural effusion, its combined morphological and functional information provide valid non-invasive method to accurately characterize pleural soft tissue diseases differentiating benign from malignant lesions with higher specificity and accuracy than conventional MRI.

scholarly journals Multiparametric MRI Texture Analysis in Prediction of Glioma Biomarker Status: Added Value of MR Diffusion

2021 ◽  
Author(s):  
Shingo Kihira ◽  
Nadejda Tsankova ◽  
Adam Bauer ◽  
Yu Sakai ◽  
Keon Mahmoudi ◽  
...  
Keyword(s):  
Texture Analysis ◽  
Diffusion Mri ◽  
Test Group ◽  
Multiparametric Mri ◽  
Added Value ◽  
Conventional Mri ◽  
Mri Features ◽  
Wide Range ◽  
Mr Diffusion ◽  
And Diffusion

Abstract Background Early identification of glioma molecular phenotypes can lead to understanding of patient prognosis and treatment guidance. We aimed to develop a multiparametric MRI texture analysis model using a combination of conventional and diffusion MRI to predict a wide range of biomarkers in patients with glioma. Methods In this retrospective study, patients were included if they 1) had diagnosis of gliomas with known IDH1, EGFR, MGMT, ATRX, TP53 and PTEN status from surgical pathology and 2) had preoperative MRI including FLAIR, T1c+ and diffusion for radiomic texture analysis. Statistical analysis included logistic regression and receiver-operating characteristic (ROC) curve analysis to determine the optimal model for predicting glioma biomarkers. A comparative analysis between ROCs (conventional only vs. conventional + diffusion) was performed. Results From a total of 111 patients included, 91 (82%) were categorized to training and 20 (18%) to test datasets. Constructed cross-validated model using a combination of texture features from conventional and diffusion MRI resulted in overall AUC/accuracy of 1/79% for IDH1, 0.99/80% for ATRX, 0.79/67% for MGMT, and 0.77/66% for EGFR. The addition of diffusion data to conventional MRI features significantly (p&lt;0.05) increased predictive performance for IDH1, MGMT and ATRX. The overall accuracy of the final model in predicting biomarkers in the test group was 80% (IDH1), 70% (ATRX), 70% (MGMT) and 75% (EGFR). Conclusion Addition of MR diffusion to conventional MRI features provides added diagnostic value in preoperative determination of IDH1, MGMT, and ATRX in patients with glioma.

scholarly journals The Role of Liver Transplantation in the Management of Paediatric Liver Tumours

2007 ◽  
Vol 89 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Mark D Stringer
Keyword(s):  
Liver Transplantation ◽  
Hepatocellular Cancer ◽  
Good Prognosis ◽  
Liver Tumours ◽  
Primary Hepatic Malignancies ◽  
Life Saving ◽  
Time Of Presentation ◽  
Benign Liver ◽  
Hepatic Malignancies

In recent years, considerable progress has been made in the treatment of children with hepatoblastoma largely due to effective pre-operative chemotherapy. Total hepatectomy and liver transplantation has emerged as an effective treatment for the small proportion of children with unresectable hepatoblastoma limited to the liver. A 5-year survival of 70% can be achieved in such cases. In contrast, the results of liver transplantation in children with hepatocellular cancer remain poor because these tumours are usually advanced with evidence of major vascular invasion and/or extrahepatic spread at the time of presentation. An exception is those children in whom the hepatocellular carcinoma is detected during surveillance of chronic liver disease – they typically have smaller tumours and frequently have a good prognosis after liver transplantation. The role of liver transplantation in children with other primary hepatic malignancies remains uncertain because experience is very limited. Liver transplantation is rarely needed in the management of children with benign liver tumours but, if other treatments have failed, it can be a life-saving intervention.

scholarly journals Preoperative chemotherapy for unresectable primary hepatic malignancies in children

Cancer ◽  
1982 ◽  
Vol 50 (6) ◽  
pp. 1061-1064 ◽  
Author(s):  
Mark E. Weinblatt ◽  
Stuart E. Siegel ◽  
Michael M. Siegel ◽  
Phillip Stanley ◽  
Jordan J. Weitzman
Keyword(s):  
Preoperative Chemotherapy ◽  
Primary Hepatic Malignancies ◽  
Hepatic Malignancies

scholarly journals IMMUNOBIOLOGICAL MONITORING OF VARIOUS GASTROINTESTINAL AND PRIMARY HEPATIC MALIGNANCIES

1997 ◽  
Vol 53 (3) ◽  
pp. 178-182
Author(s):  
GS CHOPRA ◽  
KB MISHRA ◽  
LS VOHRA ◽  
MP JAIPRAKASH ◽  
JR BHARDWAJ
Keyword(s):  
Primary Hepatic Malignancies ◽  
Hepatic Malignancies

Added value of diffusion-weighted imaging to conventional MRI for predicting fascial involvement of soft tissue sarcomas

2018 ◽  
Vol 29 (4) ◽  
pp. 1863-1873 ◽  
Author(s):  
Min A Yoon ◽  
Choong Guen Chee ◽  
Hye Won Chung ◽  
Joon Seon Song ◽  
Jong Seok Lee ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Diffusion Weighted Imaging ◽  
Soft Tissue Sarcomas ◽  
Added Value ◽  
Conventional Mri ◽  
Diffusion Weighted

scholarly journals Added value of diffusion weighted mri to conventional mri in the assessment of uterine cervix cancer post therapy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A M Nasr ◽  
O A Kamal ◽  
O F Kamel ◽  
S A N Hashim
Keyword(s):  
Cervical Cancer ◽  
Diffusion Weighted Imaging ◽  
Tumor Resection ◽  
Post Treatment ◽  
Added Value ◽  
Diffusion Weighted Mri ◽  
Conventional Mri ◽  
Diffusion Weighted ◽  
Adc Mapping ◽  
Post Therapy

Abstract Purpose of this study is: Assessing the role of Diffusion weighted imaging with ADC mapping in the evaluation of uterine cervical cancer post therapy regarding tumor residual, recurrence or post treatment benign changes/ complications after tumor resection and/or chemotherapy/radiotherapy. Methods The study included 48 female underwent cervical cancer treatment, referred to Radio diagnosis Department of National Cancer Institute for post therapy assessment. Each patient included in the study was subjected to full history taking, reviewing medical sheet and MR examination including: Conventional MR examination and Diffusion Weighted imaging. Results The study showed that the use of quantitative DW imaging with ADC mapping provide added value in the detection of post-treatment malignant masses and differentiating it from post-treatment benign changes. Conclusion The current application of diffusion Weighted MRI as a routine with conventional MRI sequences increased the accuracy of detection of post therapy benign and malignant masses , Our results suggested also that the use of ADC can be helpful in differentiating post-treatment malignant masses from benign post-treatment changes.

Case 17.24

2014 ◽  
pp. 835-836
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Duct ◽  
Hepatic Metastases ◽  
Pancreatic Head ◽  
Hepatobiliary Phase ◽  
Gadoxetate Disodium ◽  
Biliary Dilatation

64-year-old woman with pancreatic cancer and suspected hepatic metastases VR image from 3D MRCP (Figure 17.24.1) demonstrates moderate dilatation of intrahepatic ducts and marked extrahepatic biliary dilatation extending to the pancreatic head, where there is also obstruction of the pancreatic duct. Axial hepatobiliary phase 3D SPGR images obtained 20 minutes following gadoxetate disodium (Eovist) injection (...

scholarly journals Intracellular accumulation capacity of gadoxetate: initial results for a novel biomarker of liver function

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ute Lina Fahlenkamp ◽  
Katharina Ziegeler ◽  
Lisa Christine Adams ◽  
Sarah Maria Böker ◽  
Günther Engel ◽  
...  
Keyword(s):  
Liver Function ◽  
Extracellular Volume ◽  
Reduction Rate ◽  
Hepatobiliary Phase ◽  
Gadoxetate Disodium ◽  
Intracellular Accumulation ◽  
Accumulation Capacity ◽  
Contrast Agent Administration ◽  
Function Correlation ◽  
Scientific Value

Abstract Previous studies have shown gadoxetate disodium’s potential to represent liver function by its retention in the hepatobiliary phase. Additionally, in cardiac imaging, quantitative characterization of altered parenchyma is established by extracellular volume (ECV) calculation with extracellular contrast agents. Therefore, the purpose of our study was to evaluate whether intracellular accumulation capacity (IAC) of gadoxetate disodium derived from ECV calculation provides added scientific value in terms of liver function compared to the established parameter reduction rate (RR). After local review board approval, 105 patients undergoing standard MR examination with gadoxetate disodium were included. Modified Look-Locker sequences were obtained before and 20 min after contrast agent administration. RR and IAC were calculated and correlated with serum albumin, as a marker of synthetic liver function. Correlation was higher between IAC and albumin, than between RR and albumin. Additionally, capacity of both RR and IAC to distinguish between patients with or without liver cirrhosis was investigated, and differed significantly in their respective means between patients with cirrhosis and those without. We concluded, that the formula to calculate ECV can be transferred to calculate IAC of gadoxetate disodium in hepatocytes, and, thereby, IAC may possibly qualify as an imaging-based parameter to estimate synthetic liver function.

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