Best non-contrast magnetic resonance imaging sequence and role of intravenous contrast administration in evaluation of perianal fistula with surgical correlation

Author(s):  
Gaurav Chayan Das ◽  
Deba Kumar Chakrabartty
2016 ◽  
Vol 37 (3) ◽  
pp. 1108-1119 ◽  
Author(s):  
Enedino Hernández-Torres ◽  
Nora Kassner ◽  
Nils Daniel Forkert ◽  
Luxi Wei ◽  
Vanessa Wiggermann ◽  
...  

Measurements of cerebral perfusion using dynamic susceptibility contrast magnetic resonance imaging rely on the assumption of isotropic vascular architecture. However, a considerable fraction of vessels runs in parallel with white matter tracts. Here, we investigate the effects of tissue orientation on dynamic susceptibility contrast magnetic resonance imaging. Tissue orientation was measured using diffusion tensor imaging and dynamic susceptibility contrast was performed with gradient echo planar imaging. Perfusion parameters and the raw dynamic susceptibility contrast signals were correlated with tissue orientation. Additionally, numerical simulations were performed for a range of vascular volumes of both the isotropic vascular bed and anisotropic vessel components, as well as for a range of contrast agent concentrations. The effect of the contrast agent was much larger in white matter tissue perpendicular to the main magnetic field compared to white matter parallel to the main magnetic field. In addition, cerebral blood flow and cerebral blood volume were affected in the same way with angle-dependent variations of up to 130%. Mean transit time and time to maximum of the residual curve exhibited weak orientation dependency of 10%. Numerical simulations agreed with the measured data, showing that one-third of the white matter vascular volume is comprised of vessels running in parallel with the fibre tracts.


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