Papillary Thyroid Carcinoma (PTC) in Children and Adults: Comparison of Initial Presentation and Long-Term Postoperative Outcome in 4432 Patients Consecutively Treated at the Mayo Clinic During Eight Decades (1936–2015)

2017 ◽  
Vol 42 (2) ◽  
pp. 329-342 ◽  
Author(s):  
Ian D. Hay ◽  
Tammi R. Johnson ◽  
Suneetha Kaggal ◽  
Megan S. Reinalda ◽  
Nicole M. Iniguez-Ariza ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Mayo Clinic ◽  
Postoperative Outcome ◽  
Initial Presentation ◽  
Papillary Thyroid

scholarly journals Long-term survival in a patient with brain metastases of papillary thyroid carcinoma

2016 ◽  
pp. bcr2015213824
Author(s):  
Daniela Guelho ◽  
Cristina Ribeiro ◽  
Miguel Melo ◽  
Francisco Carrilho
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Brain Metastases ◽  
Papillary Thyroid ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Long-term outcomes of follicular variant vs classic papillary thyroid carcinoma

2018 ◽  
Vol 7 (12) ◽  
pp. 1226-1235 ◽  
Author(s):  
Lauren E Henke ◽  
John D Pfeifer ◽  
Thomas J Baranski ◽  
Todd DeWees ◽  
Perry W Grigsby
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Primary Study ◽  
Papillary Thyroid ◽  
Long Term Outcomes ◽  
Follicular Variant ◽  
Kaplan Meier ◽  
Mutational Status ◽  
Clinicopathologic Factors

The majority of papillary thyroid carcinoma (PTC) cases comprise classic papillary (C-PTC) and follicular variant (FV-PTC) histologic sub-types. Historically, clinical equivalency was assumed, but recent data suggest C-PTC may have poorer outcomes. However, large single-institution series with long-term outcomes of C-PTC and FV-PTC, using modern pathologic criteria for FV-PTC, are needed. Our objective was to compare prevalence and impact of clinicopathologic factors, including BRAF mutation status, on long-term outcomes of C-PTC and FV-PTC. We hypothesized that patients with C-PTC would have higher risk disease features and worse survival outcomes. This retrospective study included 1293 patients treated at a single, US academic institution between 1943 and 2009 with mean follow-up of 8.6 years. All patients underwent either partial or total thyroidectomy and had invasive C-PTC or FV-PTC per modern pathology criteria. Primary study measurements included differences in recurrence-free survival (RFS), disease-specific survival (DSS) and associations with clinicopathologic factors including the BRAF mutation. Compared to FV-PTC, C-PTC was associated with multiple features of high-risk disease (P < 0.05) and significantly reduced RFS and DSS. Survival differences were consistent across univariate, multivariate and Kaplan–Meier analyses. BRAF mutations were more common in C-PTC (P = 0.002). However, on Kaplan–Meier analysis, mutational status did not significantly impact RFS or DSS for patients with either histologic sub-type. C-PTC therefore indicates higher-risk disease and predicts for significantly poorer long-term outcomes when compared to FV-PTC. The nature of this difference in outcome is not explained by traditional histopathologic findings or by the BRAF mutation.

Pericardial tamponade as initial presentation of papillary thyroid carcinoma

2005 ◽  
Vol 31 (2) ◽  
pp. 205-207 ◽  
Author(s):  
F.M. González Valverde ◽  
M.J. Gómez Ramos ◽  
M. Moltó Aguado ◽  
M.D. Balsalobre ◽  
F. Menarguez ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Pericardial Tamponade ◽  
Initial Presentation ◽  
Papillary Thyroid

Papillary thyroid carcinoma with exuberant nodular fasciitis-like stroma: treatment outcome and prognosis

2006 ◽  
Vol 120 (4) ◽  
pp. 338-342 ◽  
Author(s):  
S Basu ◽  
N Nair ◽  
T Shet ◽  
A M Borges
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Clinical Course ◽  
Nodular Fasciitis ◽  
Rare Entity ◽  
Papillary Thyroid ◽  
Radioiodine Treatment ◽  
Long Term Follow Up

Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is one of the extremely rare variants of papillary thyroid carcinoma. To date, the majority of reported cases have been published in the surgical pathology and cytopathology literature, addressing the diagnostic difficulties posed by the condition's extensive, reactive stromal proliferation. Because of the rarity of PTC-NFS among papillary thyroid carcinoma variants, it has been unexplored from a clinical viewpoint. A MEDLINE search on the clinical course, role of radioiodine, treatment outcome and long term follow up of this disease yielded no result.We report the clinicoradiologic and histopathologic profile, together with post-treatment long term follow up, in a 35-year-old woman harbouring this rare entity. To the best of our knowledge, this is the first report of a five-year follow up of this rare variant of PTC following total thyroidectomy and radioiodine treatment. Our follow-up findings reiterate the disease's favourable clinical course when managed in the same manner as a classical, differentiated papillary carcinoma of the thyroid, akin to that predicted by the pathologists, and emphasize the importance of differentiating PTC-NFS as a separate entity from the papillary carcinoma variants with aggressive histology. Given the rarity of this condition, the experience gained from the present case is a useful addition to the current knowledge on disease prognostication and management.A systematic review of the existing literature on PTC-NFS, including the case reported in the present paper, is also carried out, aiming to explore the patient characteristics and clinical behaviour pattern of this rare entity and to make appropriate recommendations on management strategy. The age of presentation ranges from 20 to 82 years, with a mean of 44.5 years. Female preponderance was observed, with a female to male ratio of 3[ratio ]1. No racial predilection was observed. Tumour size varied from 2 to 9 cm along its greatest diameter (mean = 4.3 cm). Metastasis to lymph nodes at presentation occurred in 25 per cent of cases. Metastasis to surrounding structures (e.g. parathyroid and skeletal muscle) was observed in 12.5 per cent. There have been no reports of pulmonary or skeletal metastasis at presentation.

scholarly journals BRAF mutation is not predictive of long‐term outcome in papillary thyroid carcinoma

2015 ◽  
Vol 4 (6) ◽  
pp. 791-799 ◽  
Author(s):  
Lauren E. Henke ◽  
John D. Pfeifer ◽  
Changquing Ma ◽  
Stephanie M. Perkins ◽  
Todd DeWees ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Braf Mutation ◽  
Papillary Thyroid ◽  
Term Outcome ◽  
Long Term Outcome

Papillary Thyroid Carcinoma in Children and Adolescents: Long-Term Follow-Up and Clinical Characteristics

2015 ◽  
Vol 39 (9) ◽  
pp. 2259-2265 ◽  
Author(s):  
Kiminori Sugino ◽  
Mitsuji Nagahama ◽  
Wataru Kitagawa ◽  
Hiroshi Shibuya ◽  
Keiko Ohkuwa ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Clinical Characteristics ◽  
Papillary Thyroid ◽  
Long Term Follow Up

Long-term outcomes of central neck dissection for cN0 papillary thyroid carcinoma

2017 ◽  
Vol 38 (5) ◽  
pp. 576-581 ◽  
Author(s):  
Davide Giordano ◽  
Andrea Frasoldati ◽  
Enrico Gabrielli ◽  
Carmine Pernice ◽  
Michele Zini ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Neck Dissection ◽  
Central Neck Dissection ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Long Term Outcomes
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