Microwave Ablation of the Lung in a Porcine Model: Vessel Diameter Predicts Pulmonary Artery Occlusion

We determined the effect of pulmonary hypoperfusion on extravascular water accumulation in anesthetized dogs by occluding the left pulmonary artery for 3 h and then reperfusing it for 24 h. The lung was reperfused either at normal left atrial pressure (Pla) or during increased Pla induced by a left atrial balloon. In each case the extravascular water content-to-bloodless dry weight ratio (W/D) of the left lung was compared with that of the right lung. The W/D of the left lung of 3.26 +/- 0.49 ml/g was not significantly different from the value of 2.87 +/- 0.37 for the right lung after the reperfusion at normal Pla. However, the W/D of the left lung of 5.10 +/- 0.38 ml/g was greater (P less than 0.05) than the value of 4.42 +/- 0.34 for the right lung after reperfusion at Pla of 25 Torr. This difference could not be prevented by pretreatment with heparin, suggesting that the increase in lung water content was not due to activation of intravascular coagulation secondary to stasis occurring during the occlusion. Because the left lung was more edematous than the right one, even though both lungs had been subjected to the same increase in Pla, the results suggest that a period of pulmonary hypoperfusion causes an increase in the interstitial protein concentration.

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Comparative efficacies of unilateral pulmonary circulation temporary occlusion and simple pulmonary artery occlusion in treating lung cancer

Biomedical Research ◽

10.4066/biomedicalresearch.29-17-2991 ◽

2018 ◽

Vol 29 (2) ◽

Author(s):

Hong Li Li ◽

Chao Feng ◽

Song Tao Shi

Keyword(s):

Lung Cancer ◽

Pulmonary Artery ◽

Pulmonary Circulation ◽

Artery Occlusion ◽

Temporary Occlusion

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Clinical significance of pulmonary artery occlusion pressure

Applied Physiology in Intensive Care Medicine ◽

10.1007/3-540-37363-2_14 ◽

2007 ◽

pp. 53-56 ◽

Cited By ~ 1

Author(s):

Michael R. Pinsky

Keyword(s):

Pulmonary Artery ◽

Clinical Significance ◽

Pulmonary Artery Occlusion Pressure ◽

Artery Occlusion ◽

Occlusion Pressure

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Microvascular injury distal to unilateral pulmonary artery occlusion

Journal of Applied Physiology ◽

10.1152/jappl.1981.51.4.845 ◽

1981 ◽

Vol 51 (4) ◽

pp. 845-851 ◽

Cited By ~ 17

Author(s):

R. L. Johnson ◽

S. S. Cassidy ◽

M. Haynes ◽

R. L. Reynolds ◽

W. Schulz

Keyword(s):

Pulmonary Artery ◽

Left Lung ◽

Left Pulmonary Artery ◽

Artery Occlusion ◽

Diffusing Capacity ◽

Pulmonary Capillary Blood Flow ◽

Pulmonary Capillary ◽

Pulmonary Capillary Blood ◽

Rebreathing Method ◽

Unilateral Pulmonary Artery Occlusion

We explored three questions: 1) does edema fluid accumulate distal to temporary unilateral pulmonary artery occlusion (TUPAO); 2) if so how rapidly does it accumulate; and 3) how is it affected by positive end-expiratory pressure (PEEP)? Using a tracheal divider we measured pulmonary capillary blood flow (Qc), tissue volume (Vt), and diffusing capacity (DLCO) in each lung with a rebreathing method. After control measurements in 12 dogs, the left pulmonary artery was occluded and measurements were repeated at intervals during 4 h of occlusion and 30 min after release of the occlusion. Six of the dogs were ventilated with 10 cmH2O PEEP. Finally the lungs were removed, weighed, and fixed for histology. TUPAO caused a 29% increase in Vt of the left lung without PEEP and a 59% increase with PEEP. After release of the occlusion, Qc and DLCO in the left lung returned to control levels within 30 min in dogs not on PEEP but remained depressed in dogs ventilated with PEEP even though PEEP was removed. At postmortem the left lung weighed more than expected in both groups of dogs but was significantly heavier in those on PEEP. Histology confirmed bronchovascular cuffing with edema and hemorrhage.

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