Increased intracellular activity of matrix metalloproteinases in neutrophils may be associated with delayed healing of infection without neutropenia in myelodysplastic syndromes

2005 ◽  
Vol 84 (6) ◽  
pp. 383-388 ◽  
Author(s):  
Noritaka Yamaguchi ◽  
Yoshikazu Ito ◽  
Kazuma Ohyashiki
Keyword(s):  
Matrix Metalloproteinases ◽  
Myelodysplastic Syndromes ◽  
Intracellular Activity ◽  
Delayed Healing

Biological and clinical relevance of matrix metalloproteinases 2 and 9 in acute myeloid leukaemias and myelodysplastic syndromes

2008 ◽  
Vol 80 (3) ◽  
pp. 216-226 ◽  
Author(s):  
Erica Travaglino ◽  
Chiara Benatti ◽  
Luca Malcovati ◽  
Matteo Giovanni Della Porta ◽  
Anna Gallì ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Myelodysplastic Syndromes ◽  
Clinical Relevance ◽  
Acute Myeloid

P023 Biological and clinical relevance of matrix metalloproteinases 2 and 9 in acute myeloid leukemias and myelodysplastic syndromes

2007 ◽  
Vol 31 ◽  
pp. S53
Author(s):  
R. Invernizzi ◽  
E. Travaglino ◽  
C. Benatti ◽  
B.K. Guglielmana ◽  
L. Malcovati ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Myelodysplastic Syndromes ◽  
Clinical Relevance ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

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