scholarly journals The clinical management of lenalidomide-based therapy in patients with newly diagnosed multiple myeloma

2020 ◽  
Vol 99 (8) ◽  
pp. 1709-1725
Author(s):  
Maximilian Merz ◽  
Tobias Dechow ◽  
Mithun Scheytt ◽  
Christian Schmidt ◽  
Bjoern Hackanson ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Clinical Management ◽  
Newly Diagnosed

scholarly journals The Role of Monoclonal Antibodies in Smoldering and Newly Diagnosed Transplant-Eligible Multiple Myeloma

2020 ◽  
Vol 13 (12) ◽  
pp. 451
Author(s):  
Elena Zamagni ◽  
Paola Tacchetti ◽  
Paola Deias ◽  
Francesca Patriarca
Keyword(s):  
Multiple Myeloma ◽  
Monoclonal Antibodies ◽  
Immune System ◽  
Survival Outcomes ◽  
Newly Diagnosed ◽  
Cellular Targets ◽  
Recent Introduction

The recent introduction of monoclonal antibodies (MoAbs), with several cellular targets, such as CD-38 (daratumumab and isatuximab) and SLAM F7 (elotuzumab), differently combined with other classes of agents, has significantly extended the outcomes of patients with multiple myeloma (MM) in different phases of the disease. Initially used in advanced/refractory patients, different MoAbs combination have been introduced in the treatment of newly diagnosed transplant eligible patients (NDTEMM), showing a significant improvement in the depth of the response and in survival outcomes, without a significant price in terms of toxicity. In smoldering MM, MoAbs have been applied, either alone or in combination with other drugs, with the goal of delaying the progression to active MM and restoring the immune system. In this review, we will focus on the main results achieved so far and on the main on-going trials using MoAbs in SMM and NDTEMM.

scholarly journals Prediction of survival using absolute lymphocyte count for newly diagnosed patients with multiple myeloma: a retrospective study

2008 ◽  
Vol 141 (6) ◽  
pp. 792-798 ◽  
Author(s):  
Hilmi Ege ◽  
Morie A. Gertz ◽  
Svetomir N. Markovic ◽  
Martha Q. Lacy ◽  
Angela Dispenzieri ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Retrospective Study ◽  
Lymphocyte Count ◽  
Absolute Lymphocyte Count ◽  
Newly Diagnosed ◽  
Prediction Of Survival
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