A New Type of DNA Polymorphism Identified in the Species-Specific DNA Region Originating from the Candida albicans Mitochondrial Genome

2009 ◽  
Vol 58 (5) ◽  
pp. 438-442 ◽  
Author(s):  
Yozo Miyakawa ◽  
Takuya Ozawa
Keyword(s):  
Candida Albicans ◽  
Mitochondrial Genome ◽  
Dna Polymorphism ◽  
New Type ◽  
Species Specific

scholarly journals Molecular Diversity and Genetic Relatedness of Candida albicans Isolates from Birds in Hungary

2021 ◽  
Vol 186 (2) ◽  
pp. 237-244
Author(s):  
M. Domán ◽  
L. Makrai ◽  
Gy. Lengyel ◽  
R. Kovács ◽  
L. Majoros ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Molecular Diversity ◽  
Genetic Relatedness ◽  
Group Method ◽  
Pair Group ◽  
Degree Of Separation ◽  
Avian Origin ◽  
Species Specific ◽  
Sequence Types ◽  
Unweighted Pair Group Method

AbstractThe molecular epidemiology of Candida albicans infections in animals has been rarely studied. In this study, multilocus sequence typing was used to characterise the genetic diversity and population structure of 24 avian origin C. albicans isolates collected from different birds with candidiasis and compared to human isolates. Fourteen diploid sequence types (DSTs) including six new DSTs were determined. Cluster analysis revealed that isolates grouped into 8 clades. Bird isolates mainly belonged to minor clades and Clade 15 with DST 172 was the most common (11 isolates; 45.8%). The remaining isolates were clustered into Clade 7 (5 isolates; 20.8%), Clade 10 (4 isolates; 16.6%), Clade 8 (2 isolates; 8.3%), Clade 4 (1 isolate; 4.2%) and Clade 16 (1 isolate; 4.2%). Unweighted pair group method with arithmetic averages (UPGMA) and eBURST analyses showed that the genetic construction of avian origin C. albicans population is fairly diverse. Although species-specific lineages were not found, some degree of separation in the evolution of bird and human strains could be observed.

Mitochondrial Genome Anatomy and Species-Specific Lifespan

2006 ◽  
Vol 9 (2) ◽  
pp. 223-226 ◽  
Author(s):  
Gilad Lehmann ◽  
Arie Budovsky ◽  
Khachik K. Muradian ◽  
Vadim E. Fraifeld
Keyword(s):  
Mitochondrial Genome ◽  
Species Specific

scholarly journals Mitochondrial DNA polymorphism and cardiovascular continuum diseases

2018 ◽  
pp. 9-13
Author(s):  
М.В. Голубенко ◽  
Р.Р. Салахов ◽  
Т.В. Шумакова ◽  
С.В. Буйкин ◽  
О.А. Макеева ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cardiovascular Diseases ◽  
Mitochondrial Genome ◽  
Dna Polymorphism ◽  
Nuclear Genome ◽  
Published Data ◽  
Human Populations ◽  
Mitochondrial Dna Polymorphism ◽  
Polymorphism Level ◽  
Cardiovascular Continuum

Митохондриальный геном кодирует жизненно важные белки субъединиц дыхательной цепи и характеризуется высоким уровнем полиморфизма в популяциях человека. Однако работы по поиску генов предрасположенности к многофакторным заболеваниям, в том числе сердечно-сосудистым, часто ограничиваются анализом ядерного генома. В то же время показано, что отдельные генотипы мтДНК могут отличаться более высокой или низкой эффективностью окислительного фосфорилирования. Выявлены ассоциации популяционного полиморфизма мтДНК с сердечно-сосудистыми заболеваниями. Согласно результатам наших исследований, а также опубликованных другими авторами результатам ассоциативных и функциональных исследований, можно говорить о том, что эффект полиморфизма мтДНК проявляется чаще не в предрасположенности к сердечно-сосудистым заболеваниям в целом, а в риске развития осложнений и коморбидных фенотипов в пределах синтропии сердечно-сосудистого континуума. Mitochondrial genome, encoding respiratory chain subunits, is characterized by high polymorphism level in human populations. In most studies for susceptibility genes for common diseases, including cardiovascular diseases, the analysis is limited to the nuclear genome. It was shown that particular mtDNA genotypes may differ by oxidative phosphorylation efficiency. Some associations of mtDNA polymorphisms with cardiovascular diseases have been found. According to our results and published data, we suggest that mtDNA effect on cardiovascular system does not manifest in predisposition to cardiovascular diseases themselves but rather in risk of complications and comorbidities in the cardiovascular continuum.

scholarly journals Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal PathogenCandida albicans

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Iván Martínez-Duncker ◽  
Diana F. Díaz-Jímenez ◽  
Héctor M. Mora-Montes
Keyword(s):  
Candida Albicans ◽  
Comparative Analysis ◽  
Metabolic Pathways ◽  
Fungal Pathogen ◽  
Protein Glycosylation ◽  
Pharmacological Targets ◽  
Species Specific

Protein glycosylation pathways are present in all kingdoms of life and are metabolic pathways found in all the life kingdoms. Despite sharing commonalities in their synthesis, glycans attached to glycoproteins have species-specific structures generated by the presence of different sets of enzymes and acceptor substrates in each organism. In this review, we present a comparative analysis of the main glycosylation pathways shared by humans and the fungal pathogenCandida albicans:N-linked glycosylation,O-linked mannosylation and glycosylphosphatidylinositol-anchorage. The knowledge of similarities and divergences between these metabolic pathways could help find new pharmacological targets forC. albicansinfection.

Structural analyses of PCNA from the fungal pathogen Candida albicans identify three regions with species‐specific conformations

FEBS Letters ◽  
2021 ◽  
Author(s):  
Rajivgandhi Sundaram ◽  
Kodavati Manohar ◽  
Shraddheya Kumar Patel ◽  
Narottam Acharya ◽  
Dileep Vasudevan
Keyword(s):  
Candida Albicans ◽  
Fungal Pathogen ◽  
Species Specific

scholarly journals Species-Specific Differences in the Susceptibilities of Biofilms Formed by Candida Bloodstream Isolates to Echinocandin Antifungals

2007 ◽  
Vol 51 (4) ◽  
pp. 1520-1523 ◽  
Author(s):  
Hyun Woo Choi ◽  
Jong Hee Shin ◽  
Sook In Jung ◽  
Kyung Hwa Park ◽  
Duck Cho ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Therapeutic Range ◽  
Species Specific

ABSTRACT The echinocandin susceptibilities of bloodstream Candida isolates growing in a biofilm was investigated. Within the therapeutic range of concentrations of each drug, caspofungin and micafungin were active against biofilms formed by Candida albicans or C. glabrata but not those formed by C. tropicalis or C. parapsilosis.

Mitochondrial DNA Polymorphism in Candida albicans

1987 ◽  
Vol 156 (1) ◽  
pp. 214-215 ◽  
Author(s):  
P. D. Olivo ◽  
E. J. McManus ◽  
W. S. Riggsby ◽  
J. M. Jones
Keyword(s):  
Mitochondrial Dna ◽  
Candida Albicans ◽  
Dna Polymorphism ◽  
Mitochondrial Dna Polymorphism

scholarly journals Hospital Specificity, Region Specificity, and Fluconazole Resistance of Candida albicans Bloodstream Isolates

1998 ◽  
Vol 36 (6) ◽  
pp. 1518-1529 ◽  
Author(s):  
M. A. Pfaller ◽  
S. R. Lockhart ◽  
C. Pujol ◽  
J. A. Swails-Wenger ◽  
S. A. Messer ◽  
...  
Keyword(s):  
United States ◽  
Drug Resistance ◽  
Candida Albicans ◽  
Genetic Relatedness ◽  
Computer Assisted ◽  
Specific Probe ◽  
Fluconazole Resistance ◽  
Fluconazole Resistant ◽  
Species Specific ◽  
Close Genetic Relationship

In a survey of bloodstream infection (BSI) isolates across the continental United States, 162 Candida albicans isolates were fingerprinted with the species-specific probe Ca3 and the patterns were analyzed for relatedness with a computer-assisted system. The results demonstrate that particular BSI strains are more highly concentrated in particular geographic locales and that established BSI strains are endemic in some, but not all, hospitals in the study and undergo microevolution in hospital settings. The results, however, indicate no close genetic relationship among fluconazole-resistant BSI isolates in the collection, either from the same geographic locale or the same hospital. This study represents the first of three fingerprinting studies designed to analyze the origin, genetic relatedness, and drug resistance of Candida isolates responsible for BSI.

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