scholarly journals Nailfold capillaroscopy and autoimmune connective tissue diseases in patients from a Portuguese nailfold capillaroscopy clinic

2019 ◽  
Vol 40 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Vera Bernardino ◽  
Ana Rodrigues ◽  
Ana Lladó ◽  
António Panarra
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
Nailfold Capillaroscopy

scholarly journals Nailfold Capillaroscopy in Rheumatic Diseases

2020 ◽  
Author(s):  
Abhishek Patil ◽  
Isha Sood
Keyword(s):  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Early Diagnosis ◽  
Rheumatic Diseases ◽  
Connective Tissue Diseases ◽  
Nailfold Capillaroscopy ◽  
Indispensable Tool

Nailfold capillaroscopy (NFC) has developed into an indispensable tool for rheumatologists in the evaluation of rheumatic diseases. It offers various advantages in being rapid, noninvasive, and inexpensive. With NFC we are able to visualize the microcirculatory changes in the nail beds. These changes are key to the pathogenesis of connective tissue diseases such as systemic sclerosis. Hence NFC helps in early diagnosis of various connective tissue diseases. There is a lack of standardization in the techniques used and various capillary parameters studied, which could lead to variation in the reporting of the parameters studied. In this chapter we shall try to highlight the most common parameters studied in capillaroscopy and its utility in various connective tissue diseases.

AB0618 Nailfold Capillaroscopy Changes during Pregnancy in Connective Tissue Diseases

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 1115.2-1115
Author(s):  
M. Meroni ◽  
V.L. Ramoni ◽  
A.L. Brucato ◽  
M. Limonta ◽  
C. Pizzorni ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
Nailfold Capillaroscopy

Predictive value of nailfold capillaroscopy in the diagnosis of connective tissue diseases

1996 ◽  
Vol 15 (2) ◽  
pp. 148-153 ◽  
Author(s):  
D. Blockmans ◽  
G. Beyens ◽  
R. Verhaeghe
Keyword(s):  
Connective Tissue ◽  
Predictive Value ◽  
Connective Tissue Diseases ◽  
Nailfold Capillaroscopy

Nailfold capillaroscopy microscopy - an interdisciplinary appraisal

VASA ◽  
2016 ◽  
Vol 45 (5) ◽  
pp. 353-364 ◽  
Author(s):  
Peter Franz Klein-Weigel ◽  
Cord Sunderkötter ◽  
Oliver Sander
Keyword(s):  
Differential Diagnosis ◽  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Critical Appraisal ◽  
Connective Tissue Diseases ◽  
Diagnostic Value ◽  
Nailfold Capillaroscopy ◽  
Technical Aspects ◽  
Technical Performance ◽  
Disease Specific

Abstract. Nailfold capillaroscopy is a method of great diagnostic value in the differential diagnosis of primary versus secondary Raynaud´s phenomenon, of systemic sclerosis versus other so called connective tissue diseases and of additional diagnostic value in other entities. Rheumatologists, dermatologists, and angiologists in Germany have convened in an interdisciplinary working group in which they synergistically combined their expertise to develop a common nomenclature and standards for the technical performance of nailfold capillary microscopy. The article gives an overview of historical and technical aspects of capillaroscopy, morphologic findings, and disease-specific patterns. It also provides a critical appraisal of its significance in the diagnosis and sequelae of these interdisciplinarily-managed diseases including its performance in children and gives an excursion in the potential perspectives of capillaroscopy in less common indications.

scholarly journals Nailfold Capillaroscopy With USB Digital Microscopy in Connective Tissue Diseases: A Comparative Study of 245 Patients and Healthy Controls

2021 ◽  
Vol 8 ◽  
Author(s):  
Kumutnart Chanprapaph ◽  
Wuttidej Fakprapai ◽  
Preeyachat Limtong ◽  
Poonkiat Suchonwanit
Keyword(s):  
Connective Tissue ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Multinomial Logistic Regression ◽  
Strong Association ◽  
Prognostic Significance ◽  
Connective Tissue Diseases ◽  
Nailfold Capillaroscopy ◽  
Healthy Controls ◽  
Digital Microscopy

Background: Nailfold capillaroscopy (NFC) is a valuable tool to detect microcirculation abnormalities in connective tissue diseases (CTDs). However, whether the universal serial bus (USB) digital microscopy used as onychoscopy is as effective as the videocapillaroscopy in determining the diagnostic and prognostic values of CTDs remains to be determined.Objective: This study aims to investigate NFC features of systemic lupus erythematosus (SLE), dermatomyositis (DM), and systemic sclerosis (SSc) patients and compare with normal controls as well as examine which feature could differentiate among CTDs. Furthermore, we aim to explore different capillaroscopic abnormalities and their association with disease activity.Methods: Nailfold images were taken from patients and healthy controls using a USB digital microscopy. Patterns on the capillary morphology, diameter, architecture, and density were recorded and compared. We further determined the NFC findings in SLE, DM, and SSc and corresponded to their respective disease activity scoring system.Results: A total of 245 participants, consisting of 54 SLE, 32 DM, and 51 SSc patients, as well as 108 controls, were enrolled. All capillaroscopic features, except for tortuous capillaries, were significantly more common in CTDs than healthy control (all p < 0.05). A multinomial logistic regression analysis revealed that bushy capillaries had significantly higher odds for both SLE and DM than SSc (OR: 4.10, 95% confidence interval (CI): 1.71–9.81, p = 0.002 and OR: 7.82, 95% CI, 2.86–21.38, p < 0.001, respectively). Elongated capillaries demonstrated significant odds for SLE compared with SSc (OR: 3.35, 95% CI: 1.005–11.20, p = 0.049), while prominent subpapillary plexus showed greater odds for SLE compared with both DM and SSc (OR: 2.75, 95% CI: 1.07–7.02, p = 0.03 and OR: 5.78, 95% CI: 2.29–14.58, p < 0.001, respectively). The presence of hemorrhage, enlarged capillaries, and the low-density index had significantly higher odds in favor of SSc than SLE. Bushy capillaries were the only pattern with a strong association for DM over SSc. The presence of enlarged capillaries indicated higher SLE severity, but no specific finding was related to DM or SSc skin scores.Conclusions: Nailfold capillaroscopic examination using a digital microscope is a valuable method for the diagnosis of SLE, DM, and SSc. Several morphologic patterns can help differentiate among CTDs; however, the prognostic significance of this method requires further investigations.

scholarly journals Might Nailfold Capillaroscopy Be a “Proxy” for Lung Involvement in Connective Tissue Diseases?

2019 ◽  
Vol 46 (9) ◽  
pp. 1061-1063 ◽  
Author(s):  
VANESSA SMITH ◽  
OLIVER DISTLER ◽  
MAURIZIO CUTOLO
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
Nailfold Capillaroscopy ◽  
Lung Involvement
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