Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma: a preliminary case–control study

2012 ◽  
Vol 23 (1) ◽  
pp. 156-162 ◽  
Author(s):  
Utaroh Motosugi ◽  
Tomoaki Ichikawa ◽  
Tsuyota Koshiishi ◽  
Katsuhiro Sano ◽  
Hiroyuki Morisaka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Magnetic Resonance ◽  
Case Control Study ◽  
Liver Stiffness ◽  
Case Control ◽  
Magnetic Resonance Elastography ◽  
Control Study

scholarly journals Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case–control study

2008 ◽  
Vol 89 (11) ◽  
pp. 2882-2890 ◽  
Author(s):  
Zhong-Liao Fang ◽  
Caroline A. Sabin ◽  
Bai-Qing Dong ◽  
Shao-Chao Wei ◽  
Qin-Yan Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Deletion Mutations ◽  
B Virus ◽  
Nested Case Control ◽  
Control Study

A matched nested case–control study of 33 paired cases and controls was conducted, based on a study cohort in Long An county, Guangxi, China, to determine whether infection with hepatitis B virus (HBV) with pre-S deletions is independently associated with the development of hepatocellular carcinoma (HCC), without the confounding effects of basal core promoter (BCP) double mutations. The prevalence of pre-S deletions was significantly higher in HCC (45.5 %, 15 of 33) than the controls (18.2 %, 6 of 33) (P<0.01), under the control of the influence of BCP double mutations. Most of the pre-S deletions occurred in, or involved, the 5′ half of the pre-S2 region and the difference between HCC (93.3 %, 14 of 15) and controls (66.7 %, four of six) was significant for this region (P=0.015). There was no significant difference in pre-S deletions between the BCP mutant group and BCP wild-type group (P>0.05), nor was the prevalence of pre-S deletions significantly different between genotypes B and C (P>0.1). These results suggest that pre-S deletions constitute an independent risk factor for HCC and their emergence and effect are independent of BCP mutations. The 5′ terminus of pre-S2 is the favoured site for the deletion mutations, especially in HCC cases. Further prospective studies are required to confirm the role of these mutations in the development of HCC.

scholarly journals Betel quid chewing as a risk factor for hepatocellular carcinoma: a case–control study

2001 ◽  
Vol 84 (5) ◽  
pp. 709-713 ◽  
Author(s):  
J F Tsai ◽  
L Y Chuang ◽  
J E Jeng ◽  
M S Ho ◽  
M Y Hsieh ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Case Control Study ◽  
Case Control ◽  
Betel Quid ◽  
Betel Quid Chewing ◽  
Control Study

Anti-hepatitis B core positivity as a risk factor for hepatocellular carcinoma in alcoholic cirrhosis: A case–control study

Alcohol ◽  
2012 ◽  
Vol 46 (6) ◽  
pp. 537-541 ◽  
Author(s):  
Oh Sang Kwon ◽  
Young Kul Jung ◽  
Kyoung Suk Bae ◽  
Ju Hyun Kim ◽  
Sang Gyune Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Hepatitis B ◽  
Case Control Study ◽  
Alcoholic Cirrhosis ◽  
Case Control ◽  
Control Study
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